HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: AGO3 (Q9H9G7)
Protein argonaute-3 (Argonaute3) (hAgo3) (EC 3.1.26.n2) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3)
Gene: AGO3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.691

Property	Details
Experiments	26186194, 28514442, 33961781, 19167051
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol and 1 others more... GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 860
+	Hs
		438537 HS90B_HUMAN (19-732): 0: 1059: 86.13		AGO3_HUMAN (1-860): 0: 1182: 100.00
+	Hs
		432356 HS90A_HUMAN (1-732): 0: 1087: 100.00		AGO1_HUMAN (9-860): 0: 1150: 84.62
+	Hs
		432355 HS90A_HUMAN (1-732): 0: 1087: 100.00		AGO2_HUMAN (15-860): 0: 1142: 80.73
+	Mm
		432448 HS90A_MOUSE (1-732): 0: 1083: 97.82		AGO2_MOUSE (3-860): 0: 1144: 79.56
+	Hs
		438615 HS90B_HUMAN (19-732): 0: 1059: 86.13		AGO1_HUMAN (9-860): 0: 1150: 84.62
+	Mm
		1174807 Q71LX8_MOUSE (19-732): 0: 1063: 86.98		AGO2_MOUSE (3-860): 0: 1144: 79.56
+	Hs
		432278 HS90A_HUMAN (1-732): 0: 1087: 100.00		AGO4_HUMAN (3-860): 0: 1118: 80.81
+	Hs
		438614 HS90B_HUMAN (19-732): 0: 1059: 86.13		AGO2_HUMAN (15-860): 0: 1142: 80.73
+	Hs
		438545 HS90B_HUMAN (19-732): 0: 1059: 86.13		AGO4_HUMAN (3-860): 0: 1118: 80.81
+	Dm
		365460 HSP83_DROME (15-732): 0: 1034: 78.41		Q32KD4_DROME (1-860): 0: 1102: 70.89
+	At
		138329 HS903_ARATH (15-732): 0: 981: 67.96		AGO1_ARATH (7-859): 0: 1064: 42.91
+	Hs
		1123461 H90B3_HUMAN (19-732): 0: 728: 65.41		AGO3_HUMAN (1-860): 0: 1182: 100.00
+	Hs
		432159 HS90A_HUMAN (1-732): 0: 1087: 100.00		PIWL1_HUMAN (9-827): 0: 769: 21.57
+	Hs
		432088 HS90A_HUMAN (1-732): 0: 1087: 100.00		PIWL2_HUMAN (5-822): 0: 710: 21.39
+	Hs
		432003 HS90A_HUMAN (1-732): 0: 1087: 100.00		PIWL4_HUMAN (11-823): 0: 677: 20.96
+	Hs
		1123440 H90B4_HUMAN (30-604): 0: 571: 62.61		AGO3_HUMAN (1-860): 0: 1182: 100.00
+	Dm
		365485 HSP83_DROME (15-732): 0: 1034: 78.41		AGO2_DROME (22-820): 0: 696: 30.41
+	Dm
		365462 HSP83_DROME (15-732): 0: 1034: 78.41		AGO3_DROME (23-827): 0: 624: 20.05
+	Dm
		365480 HSP83_DROME (15-732): 0: 1034: 78.41		PIWI_DROME (21-827): 0: 614: 21.64
+	Hs
		431946 HS90A_HUMAN (1-732): 0: 1087: 100.00		Q5TA56_HUMAN (1-219): 4.81e-159: 464: 100.00