Protein: METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) (Cobalamin-independent methionine synthase) (Delta-P8 protein) (Methionine synthase, vitamin-B12 independent isozyme)

Gene: METE, MET6
Organism: Saccharomyces cerevisiae S288C
Interactions: 129
UniProt ID: P05694

Gene Ontology (top 5):
GO:0003871 - 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0008270 - zinc ion binding
GO:0009086 - methionine biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

391969

HSP82
ATP-dependent molecular chaperone HSP82

2

1

High-throughput

0.584

High

432282

HSC82
ATP-dependent molecular chaperone HSC82

2

1

High-throughput

0.571

High

432276

HSP72
Heat shock protein SSA2

2

2

High-throughput

0.552

High

432277

SSB1
Ribosome-associated molecular chaperone SSB1

2

2

High-throughput

0.552

High

432334

SSB2
Ribosome-associated molecular chaperone SSB2

2

2

High-throughput

0.552

High

432291

SIS1
Protein SIS1

2

1

High-throughput

0.537

High

432301

CDC12
Cell division control protein 12

1

0

High-throughput

0.513

High

432331

RSP5
E3 ubiquitin-protein ligase RSP5

1

1

Small-scale

0.501

High

432342

ENT3
Epsin-3

1

1

Small-scale

0.501

High

432361

ENT5
Epsin-5

1

1

Small-scale

0.501

High

432280

PP2B2
Serine/threonine-protein phosphatase 2B catalytic subunit A2

1

1

High-throughput

0.500

High

432366

IMB1
Importin subunit beta-1

1

0

High-throughput

0.493

High

432369

HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1

1

0

High-throughput

0.493

High

432281

AMPL
Vacuolar aminopeptidase 1

1

0

High-throughput

0.479

High

432283

PHO85
Cyclin-dependent protein kinase PHO85

1

0

High-throughput

0.479

High

432285

GBB
Guanine nucleotide-binding protein subunit beta

1

0

High-throughput

0.479

High

432288

FKBP
FK506-binding protein 1

1

0

High-throughput

0.479

High

432290

KC11
Casein kinase I homolog 1

1

0

High-throughput

0.479

High

432292

MSH3
DNA mismatch repair protein MSH3

1

0

High-throughput

0.479

High

432295

GID7
GID complex subunit 7

1

0

High-throughput

0.479

High

432305

PP12
Serine/threonine-protein phosphatase PP1-2

1

0

High-throughput

0.479

High

432312

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

High-throughput

0.479

High

432317

VPS21
Vacuolar protein sorting-associated protein 21

1

0

High-throughput

0.479

High

432329

RV167
Reduced viability upon starvation protein 167

1

0

High-throughput

0.479

High

432330

AFG3
Mitochondrial inner membrane m-AAA protease component YTA10

1

0

High-throughput

0.479

High

432339

RIM15
Serine/threonine-protein kinase RIM15

1

0

High-throughput

0.479

High

432343

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.479

High

432350

RHO4
GTP-binding protein RHO4

1

0

High-throughput

0.479

High

432351

2ABA
Protein phosphatase PP2A regulatory subunit B

1

0

High-throughput

0.479

High

432355

IMA1
Importin subunit alpha

1

0

High-throughput

0.479

High

432359

STE20
Serine/threonine-protein kinase STE20

1

0

High-throughput

0.479

High

432368

PRP11
Pre-mRNA-splicing factor PRP11

1

0

High-throughput

0.479

High

432372

CDC53
Cell division control protein 53

1

0

High-throughput

0.479

High

358929

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

2

High-throughput

0.479

High

359105

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

2

High-throughput

0.479

High

359398

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

2

High-throughput

0.479

High

365515

PGK
Phosphoglycerate kinase

1

1

High-throughput

0.479

High

367640

ENO1
Enolase 1

1

1

High-throughput

0.479

High

367841

ENO2
Enolase 2

1

1

High-throughput

0.479

High

432358

TOM1
E3 ubiquitin-protein ligase TOM1

1

1

High-throughput

0.479

High

149464

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

368373

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.458

High

416329

HXKA
Hexokinase-1

1

0

High-throughput

0.458

High

432264

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

432266

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.458

High

432270

PBS2
MAP kinase kinase PBS2

1

0

High-throughput

0.458

High

432274

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

432278

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.458

High

432279

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.458

High

432284

MDHM
Malate dehydrogenase, mitochondrial

1

0

Small-scale

0.458

High

432293

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

432298

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

432299

HS104
Heat shock protein 104

1

0

High-throughput

0.458

High

432303

HOG1
Mitogen-activated protein kinase HOG1

1

0

High-throughput

0.458

High

432308

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

432311

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

432315

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

432318

LAS1
Protein LAS1

1

0

Small-scale

0.458

High

432319

RMD9L
RNA-binding protein RMD9-like, mitochondrial

1

0

High-throughput

0.458

High

432321

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

432322

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

0

High-throughput

0.458

High

432325

MET30
F-box protein MET30

1

0

High-throughput

0.458

High

432327

DHH1
ATP-dependent RNA helicase DHH1

1

0

High-throughput

0.458

High

432333

YEY6
MYG1 protein YER156C

1

0

Small-scale

0.458

High

432336

EGH1
Ergosteryl-beta-glucosidase

1

0

High-throughput

0.458

High

432338

GPP1
Glycerol-1-phosphate phosphohydrolase 1

1

0

High-throughput

0.458

High

432347

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

432352

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

432356

ESP1
Separin

1

0

High-throughput

0.458

High

432357

COFI
Cofilin

1

0

High-throughput

0.458

High

432370

SGO1
Shugoshin

1

0

High-throughput

0.458

High

432376

CMR1
DNA damage-binding protein CMR1

1

0

High-throughput

0.458

High

432271

HSP73
Heat shock protein SSA3

1

2

High-throughput

0.445

High

432275

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.445

High

432326

CAJ1
Protein CAJ1

1

1

High-throughput

0.445

High

432332

HSP7E
Heat shock protein SSC3, mitochondrial

1

1

High-throughput

0.445

High

432365

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

4

High-throughput

0.445

High

432307

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

432375

DBP10
ATP-dependent RNA helicase DBP10

1

1

High-throughput

0.437

High

432294

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.426

High

432344

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.426

High

432316

LHS1
Heat shock protein 70 homolog LHS1

1

3

High-throughput

0.407

High

432377

SMC6
Structural maintenance of chromosomes protein 6

2

0

High-throughput

0.310

High

432340

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

0

High-throughput

0.305

High

432341

FIP1
Pre-mRNA polyadenylation factor FIP1

1

0

High-throughput

0.279

Low

432353

RT16
Small ribosomal subunit protein bS16m

1

0

High-throughput

0.279

Low

432363

ERB1
Ribosome biogenesis protein ERB1

1

0

High-throughput

0.279

Low

432364

SEN15
tRNA-splicing endonuclease subunit SEN15

1

0

High-throughput

0.279

Low

381347

H2B2
Histone H2B.2

1

0

High-throughput

0.269

Low

432269

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.261

Low

432286

PRP6
Pre-mRNA-splicing factor 6

1

0

High-throughput

0.261

Low

432287

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

1

0

High-throughput

0.261

Low

432289

DBF2
Cell cycle protein kinase DBF2

1

0

High-throughput

0.261

Low

432300

CDC3
Cell division control protein 3

1

0

High-throughput

0.261

Low

432302

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

0

High-throughput

0.261

Low

432304

EI2BB
Translation initiation factor eIF2B subunit beta

1

0

High-throughput

0.261

Low

432306

CDC13
Cell division control protein 13

1

0

High-throughput

0.261

Low

432309

SUI1
Eukaryotic translation initiation factor eIF-1

1

0

High-throughput

0.261

Low

432324

TEM1
Protein TEM1

1

0

High-throughput

0.261

Low

432345

SEH1
Nucleoporin SEH1

1

0

High-throughput

0.261

Low

432374

ATG5
Autophagy protein 5

1

0

High-throughput

0.261

Low

432354

ULP1
Ubiquitin-like-specific protease 1

1

0

High-throughput

0.251

Low

368534

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.249

Low

401801

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.249

Low

409817

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

415188

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.249

Low

432265

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.249

Low

432267

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

432268

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

432272

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

432273

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

432296

CDC48
Cell division control protein 48

1

0

High-throughput

0.249

Low

432297

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

432310

YPT7
Ypt/Rab-type GTPase YPT7

1

0

Small-scale

0.249

Low

432313

IXR1
Intrastrand cross-link recognition protein

1

0

Small-scale

0.249

Low

432314

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

432320

YB8A
Putative uncharacterized protein YBR285W

1

0

Small-scale

0.249

Low

432323

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.249

Low

432328

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

432335

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.249

Low

432337

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

432346

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

0

High-throughput

0.249

Low

432349

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

432360

ESC1
Silent chromatin protein ESC1

1

0

High-throughput

0.249

Low

432362

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.249

Low

432367

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

432371

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

432373

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.249

Low

432348

ALG12
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025