HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22939624
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0032991 - protein-containing complex GO:0042981 - regulation of apoptotic process GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 1620
+	Hs
		431435 HS90A_HUMAN (1-732): 0: 1087: 100.00		RET_HUMAN (842-1477): 4.8e-137: 455: 23.56
+	Hs
		431691 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHB1_HUMAN (938-1436): 5.66e-129: 429: 25.25
+	Hs
		431871 HS90A_HUMAN (1-732): 0: 1087: 100.00		ERBB4_HUMAN (882-1547): 2.9e-122: 418: 22.24
+	Hs
		431626 HS90A_HUMAN (1-732): 0: 1087: 100.00		ABL2_HUMAN (1103-1526): 1.55e-118: 405: 32.47
+	Hs
		431562 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA3_HUMAN (943-1427): 7.27e-120: 404: 25.87
+	Hs
		431536 HS90A_HUMAN (1-732): 0: 1087: 100.00		FGFR3_HUMAN (952-1449): 6.42e-121: 401: 26.31
+	Hs
		169159 HS90A_HUMAN (1-732): 0: 1087: 100.00		MUSK_HUMAN (983-1391): 2.02e-118: 396: 29.98
+	Hs
		431472 HS90A_HUMAN (1-732): 0: 1087: 100.00		FGFR1_HUMAN (952-1454): 2.04e-118: 395: 26.06
+	Hs
		431438 HS90A_HUMAN (1-732): 0: 1087: 100.00		IGF1R_HUMAN (1037-1385): 8.86e-111: 386: 39.77
+	Hs
		431848 HS90A_HUMAN (1-732): 0: 1087: 100.00		FAK2_HUMAN (1054-1518): 4.66e-109: 374: 27.45
+	Hs
		169160 HS90B_HUMAN (19-732): 0: 1059: 86.13		MUSK_HUMAN (983-1391): 2.02e-118: 396: 29.98
+	Hs
		435497 HS90B_HUMAN (19-732): 0: 1059: 86.13		IGF1R_HUMAN (1037-1385): 8.86e-111: 386: 39.77
+	Hs
		431488 HS90A_HUMAN (1-732): 0: 1087: 100.00		INSRR_HUMAN (1082-1384): 2.38e-70: 262: 43.46
+	Hs
		431901 HS90A_HUMAN (1-732): 0: 1087: 100.00		NTRK2_HUMAN (1093-1375): 7.35e-64: 236: 41.44
+	Hs
		384111 HS90A_HUMAN (1-732): 0: 1087: 100.00		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		431507 HS90A_HUMAN (1-732): 0: 1087: 100.00		FER_HUMAN (1101-1377): 1.53e-59: 223: 40.35
+	Hs
		431892 HS90A_HUMAN (1-732): 0: 1087: 100.00		NTRK3_HUMAN (1093-1375): 2.69e-59: 223: 39.03
+	Hs
		426936 HS90A_HUMAN (1-732): 0: 1087: 100.00		FES_HUMAN (1114-1384): 4.5e-59: 222: 42.80
+	Hs
		384122 HS90B_HUMAN (19-732): 0: 1059: 86.13		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		426937 HS90B_HUMAN (19-732): 0: 1059: 86.13		FES_HUMAN (1114-1384): 4.5e-59: 222: 42.80