HitPredict

Interactor 1: HS90A (P07901)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Tumor-specific transplantation 86 kDa antigen) (TSTA)
Gene: Hsp90aa1

Interactor 2: ITBP2 (Q9R000)
Integrin beta-1-binding protein 2 (Melusin)
Gene: Itgb1bp2

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.80	0.751

Property	Details
Experiments	23184943, 18474241
Identification Methods	pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, surface plasmon resonance, cross-linking study, enzyme linked immunosorbent assay
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	CHORD~HSP90
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 733 Mm			1 350
+	Hs
		432350 HS90A_HUMAN (1-733): 0: 1078: 98.23		ITBP2_HUMAN (1-350): 9.14e-161: 455: 91.74
+	Mm
		513706 HS90B_MOUSE (19-733): 0: 1053: 86.15		ITBP2_MOUSE (1-350): 1.11e-168: 475: 100.00
+	Hs
		438609 HS90B_HUMAN (19-733): 0: 1049: 85.87		ITBP2_HUMAN (1-350): 9.14e-161: 455: 91.74
+	Hs
		111942 K9JA46_HUMAN (1-733): 0: 1078: 98.23		CHRD1_HUMAN (1-321): 2e-140: 403: 47.01
+	Hs
		432333 HS90A_HUMAN (1-733): 0: 1078: 98.23		CHRD1_HUMAN (1-321): 2e-140: 403: 47.01
+	Mm
		432455 HS90A_MOUSE (1-733): 0: 1083: 100.00		CHRD1_MOUSE (1-318): 4.39e-136: 391: 46.53
+	Hs
		438592 HS90B_HUMAN (19-733): 0: 1049: 85.87		CHRD1_HUMAN (1-321): 2e-140: 403: 47.01
+	Mm
		513702 HS90B_MOUSE (19-733): 0: 1053: 86.15		CHRD1_MOUSE (1-318): 4.39e-136: 391: 46.53
+	Dm
		365474 HSP83_DROME (15-733): 0: 1023: 77.61		CHRD1_DROME (4-340): 2.73e-135: 390: 38.91
+	Hs
		432387 HS90A_HUMAN (1-733): 0: 1078: 98.23		SGT1_HUMAN (122-336): 1.29e-74: 236: 18.85
+	Hs
		438644 HS90B_HUMAN (19-733): 0: 1049: 85.87		SGT1_HUMAN (122-336): 1.29e-74: 236: 18.85
+	At
		646596 HS901_ARATH (15-733): 0: 980: 68.98		SGT1A_ARATH (123-346): 3.34e-60: 198: 17.12
+	At
		878286 HS902_ARATH (15-733): 0: 981: 68.28		SGT1B_ARATH (123-346): 2.47e-56: 188: 15.47
+	At
		646597 HS901_ARATH (15-733): 0: 980: 68.98		SGT1B_ARATH (123-346): 2.47e-56: 188: 15.47
+	Hs
		538450 ENPL_HUMAN (14-702): 0: 891: 46.86		SGT1_HUMAN (122-336): 1.29e-74: 236: 18.85
+	Ce
		1090253 HSP90_CAEEL (14-733): 0: 956: 74.31		Q18949_CAEEL (216-346): 5.09e-33: 123: 21.21
+	At
		878285 HS902_ARATH (15-733): 0: 981: 68.28		RAR1_ARATH (150-218): 1.3e-13: 71: 40.58
+	At
		646595 HS901_ARATH (15-733): 0: 980: 68.98		RAR1_ARATH (150-218): 1.3e-13: 71: 40.58
+	Sc
		367015 HSP82_YEAST (16-733): 0: 900: 60.56		SGT1_YEAST (212-347): 5.62e-32: 125: 18.87
+	Sc
		544530 HSC82_YEAST (16-733): 0: 898: 59.44		SGT1_YEAST (212-347): 5.62e-32: 125: 18.87