HitPredict

Interactor 1: HNRPC (P07910)
Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2)
Gene: HNRNPC

Interactor 2: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.839

Property	Details
Experiments	29884807, 35271311, 27460707
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0003730 - mRNA 3'-UTR binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0008380 - RNA splicing
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 306 Hs			1 526
+	Hs
		241339 HNRC1_HUMAN (1-306): 2.22e-87: 265: 86.93		RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10
+	Hs
		241277 HNRC1_HUMAN (1-306): 2.22e-87: 265: 86.93		FUS_HUMAN (1-526): 1.99e-39: 152: 100.00
+	Hs
		432837 HNRPC_HUMAN (1-306): 1.06e-83: 256: 100.00		RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10
+	Hs
		241386 HNRC1_HUMAN (1-306): 2.22e-87: 265: 86.93		PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46
+	Hs
		432996 HNRPC_HUMAN (1-306): 1.06e-83: 256: 100.00		PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46
+	Mm
		1144850 RALY_MOUSE (3-300): 1.41e-66: 212: 42.19		Q8BQ46_MOUSE (42-460): 2.55e-40: 155: 48.34
+	Hs
		433014 HNRPC_HUMAN (1-306): 1.06e-83: 256: 100.00		RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35
+	Hs
		727088 RALY_HUMAN (2-298): 3.88e-63: 203: 40.19		FUS_HUMAN (1-526): 1.99e-39: 152: 100.00
+	Mm
		882689 RALY_MOUSE (3-300): 1.41e-66: 212: 42.19		FUS_MOUSE (1-526): 6.91e-34: 136: 86.72
+	Mm
		1142748 RALY_MOUSE (3-300): 1.41e-66: 212: 42.19		EWS_MOUSE (3-451): 2.8e-30: 127: 35.56
+	Hs
		967252 RALYL_HUMAN (3-284): 4.85e-66: 210: 52.23		EWS_HUMAN (3-451): 5.13e-31: 129: 31.05
+	Hs
		1197556 RALYL_HUMAN (3-284): 4.85e-66: 210: 52.23		PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46
+	Hs
		1356521 RALY_HUMAN (2-298): 3.88e-63: 203: 40.19		PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46
+	Hs
		432527 HNRPC_HUMAN (1-306): 1.06e-83: 256: 100.00		PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44
+	Mm
		665756 RALY_MOUSE (3-300): 1.41e-66: 212: 42.19		PABP1_MOUSE (184-382): 3.6e-12: 70.8: 12.44
+	Hs
		516734 RALY_HUMAN (2-298): 3.88e-63: 203: 40.19		PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44
+	Hs
		925089 TRA2B_HUMAN (4-164): 1.14e-27: 110: 21.77		RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10
+	Hs
		726730 TRA2B_HUMAN (4-164): 1.14e-27: 110: 21.77		FUS_HUMAN (1-526): 1.99e-39: 152: 100.00
+	Hs
		925008 TRA2B_HUMAN (4-164): 1.14e-27: 110: 21.77		EWS_HUMAN (3-451): 5.13e-31: 129: 31.05
+	Hs
		516451 TRA2B_HUMAN (4-164): 1.14e-27: 110: 21.77		PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44