HitPredict

Interactor 1: YES (P07947)
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Gene: YES1

Interactor 2: PTPRE (P23469)
Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48)
Gene: PTPRE

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase, SH2~Y_phosphatase
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 543 Hs			1 700
+	Hs
		412017 FYN_HUMAN (1-543): 0: 582: 72.16		PTPRE_HUMAN (1-700): 0: 885: 100.00
+	Hs
		412016 FYN_HUMAN (1-543): 0: 582: 72.16		PTPRD_HUMAN (1-697): 0: 883: 41.54
+	Hs
		522756 SRC_HUMAN (1-543): 0: 601: 74.22		PTPRA_HUMAN (13-700): 0: 863: 66.52
+	Rn
		1146020 SRC_RAT (1-543): 0: 600: 73.67		Q66HJ7_RAT (26-700): 0: 858: 67.21
+	Mm
		56907 FYN_MOUSE (1-543): 0: 582: 71.98		PTPRF_MOUSE (3-697): 0: 869: 42.35
+	Hs
		411959 FYN_HUMAN (1-543): 0: 582: 72.16		PTPRF_HUMAN (3-697): 0: 864: 42.21
+	Hs
		411997 FYN_HUMAN (1-543): 0: 582: 72.16		PTPRA_HUMAN (13-700): 0: 863: 66.52
+	Rn
		976063 SRC_RAT (1-543): 0: 600: 73.67		PTPRA_RAT (26-700): 0: 843: 66.47
+	Mm
		403413 SRC_MOUSE (1-543): 0: 598: 73.67		PTPRA_MOUSE (26-700): 0: 842: 64.10
+	Rn
		1144045 FYN_RAT (1-543): 0: 581: 71.80		Q66HJ7_RAT (26-700): 0: 858: 67.21
+	Mm
		574000 FYN_MOUSE (1-543): 0: 582: 71.98		PTPRA_MOUSE (26-700): 0: 842: 64.10
+	Hs
		411565 LCK_HUMAN (83-541): 0: 540: 60.78		PTPRF_HUMAN (3-697): 0: 864: 42.21
+	Rn
		94284 FYN_RAT (1-543): 0: 581: 71.80		F1LXJ9_RAT (81-693): 0: 725: 37.80
+	Hs
		522755 SRC_HUMAN (1-543): 0: 601: 74.22		PTN1_HUMAN (425-700): 3.73e-109: 339: 26.35
+	Hs
		411596 LCK_HUMAN (83-541): 0: 540: 60.78		PTPRB_HUMAN (336-692): 2.25e-108: 363: 30.66
+	Hs
		441169 SRC_HUMAN (1-543): 0: 601: 74.22		PTPRC_HUMAN (119-409): 3.12e-76: 268: 30.63
+	Hs
		411950 FYN_HUMAN (1-543): 0: 582: 72.16		PTPRC_HUMAN (119-409): 3.12e-76: 268: 30.63
+	Hs
		411557 LCK_HUMAN (83-541): 0: 540: 60.78		PTPRC_HUMAN (119-409): 3.12e-76: 268: 30.63
+	Mm
		411913 LCK_MOUSE (83-541): 0: 542: 60.78		PTPRC_MOUSE (120-423): 1.56e-71: 255: 28.61
+	Hs
		412018 FYN_HUMAN (1-543): 0: 582: 72.16		PTPRZ_HUMAN (131-410): 3.17e-55: 207: 28.82