HitPredict

Interactor 1: YES (P07947)
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Gene: YES1

Interactor 2: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	7499252
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 543 Hs			1 583
+	Hs
		522805 SRC_HUMAN (1-543): 0: 601: 74.22		SHC1_HUMAN (1-583): 0: 531: 100.00
+	Mm
		403430 SRC_MOUSE (1-543): 0: 598: 73.67		SHC1_MOUSE (1-583): 0: 527: 94.51
+	Mm
		403451 SRC_MOUSE (1-543): 0: 598: 73.67		SHC2_MOUSE (43-582): 6.38e-127: 386: 45.91
+	Mm
		403440 SRC_MOUSE (1-543): 0: 598: 73.67		SHC3_MOUSE (128-582): 1.14e-111: 343: 53.26
+	Hs
		411981 FYN_HUMAN (1-543): 0: 582: 72.16		VAV_HUMAN (163-578): 1.81e-54: 200: 12.25
+	Hs
		433263 YES_HUMAN (1-543): 0: 617: 100.00		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		442772 SRC_HUMAN (1-543): 0: 601: 74.22		HCK_HUMAN (348-575): 2.72e-43: 164: 17.16
+	Hs
		523000 SRC_HUMAN (1-543): 0: 601: 74.22		SHB_HUMAN (369-579): 2.01e-41: 158: 20.63
+	Hs
		522868 SRC_HUMAN (1-543): 0: 601: 74.22		BMX_HUMAN (341-582): 1.11e-38: 153: 19.69
+	Hs
		522796 SRC_HUMAN (1-543): 0: 601: 74.22		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		433433 YES_HUMAN (1-543): 0: 617: 100.00		P55G_HUMAN (473-581): 3.75e-31: 128: 29.20
+	Hs
		411986 FYN_HUMAN (1-543): 0: 582: 72.16		NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30
+	Mm
		763403 FYN_MOUSE (1-543): 0: 582: 71.98		NCK1_MOUSE (360-575): 1.9e-41: 155: 18.30
+	Hs
		412033 FYN_HUMAN (1-543): 0: 582: 72.16		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Mm
		643066 FYN_MOUSE (1-543): 0: 582: 71.98		P85A_MOUSE (300-581): 6.66e-38: 151: 15.99
+	Hs
		523089 SRC_HUMAN (1-543): 0: 601: 74.22		P55G_HUMAN (473-581): 3.75e-31: 128: 29.20
+	Hs
		129185 SRC_HUMAN (1-543): 0: 601: 74.22		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		129164 FYN_HUMAN (1-543): 0: 582: 72.16		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		522887 SRC_HUMAN (1-543): 0: 601: 74.22		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Mm
		763393 FYN_MOUSE (1-543): 0: 582: 71.98		GRB2_MOUSE (482-578): 3.54e-15: 76.8: 30.48