HitPredict

Interactor 1: YES (P07947)
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Gene: YES1

Interactor 2: LASP1 (Q14847)
LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50)
Gene: LASP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid array, validated two hybrid, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 543 Hs			1 261
+	Hs
		433350 YES_HUMAN (1-543): 0: 617: 100.00		SRC8_HUMAN (38-260): 4.28e-23: 99: 17.62
+	Hs
		522981 SRC_HUMAN (1-543): 0: 601: 74.22		SRC8_HUMAN (38-260): 4.28e-23: 99: 17.62
+	Hs
		411992 FYN_HUMAN (1-543): 0: 582: 72.16		PLCG2_HUMAN (15-261): 2.82e-22: 98: 13.77
+	Hs
		412328 FYN_HUMAN (1-543): 0: 582: 72.16		SH3G2_HUMAN (47-261): 5.88e-23: 98: 18.14
+	Mm
		763400 FYN_MOUSE (1-543): 0: 582: 71.98		PLCG2_MOUSE (17-261): 7.01e-22: 96.9: 13.88
+	Hs
		412329 FYN_HUMAN (1-543): 0: 582: 72.16		SH3G3_HUMAN (47-261): 7.91e-22: 94.5: 16.97
+	Hs
		523130 SRC_HUMAN (1-543): 0: 601: 74.22		SRBS1_HUMAN (149-259): 7.54e-13: 69.9: 31.30
+	Hs
		433732 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		MYO1E_HUMAN (36-261): 8.28e-25: 105: 15.04
+	Hs
		434085 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		BAIP2_HUMAN (19-261): 1.26e-24: 104: 15.75
+	Mm
		639446 LYN_MOUSE (1-541): 1.19e-179: 517: 53.14		SRC8_MOUSE (59-260): 8.14e-23: 99.2: 21.68
+	Mm
		639449 LYN_MOUSE (1-541): 1.19e-179: 517: 53.14		DBNL_MOUSE (54-261): 1.96e-22: 97.2: 22.48
+	Mm
		639456 LYN_MOUSE (1-541): 1.19e-179: 517: 53.14		PLCG2_MOUSE (17-261): 7.01e-22: 96.9: 13.88
+	Hs
		433564 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		PLCG2_HUMAN (15-261): 2.82e-22: 98: 13.77
+	Hs
		789066 ABL2_HUMAN (9-543): 9.27e-166: 503: 37.96		SRC8_HUMAN (38-260): 4.28e-23: 99: 17.62
+	Hs
		562634 BLK_HUMAN (66-538): 5.05e-174: 502: 59.07		PLCG2_HUMAN (15-261): 2.82e-22: 98: 13.77
+	Mm
		557351 BLK_MOUSE (78-538): 3.57e-174: 502: 59.96		PLCG2_MOUSE (17-261): 7.01e-22: 96.9: 13.88
+	Mm
		337624 ABL1_MOUSE (41-543): 2.47e-161: 490: 39.10		PPIP1_MOUSE (3-261): 5.87e-26: 106: 14.75
+	Hs
		433807 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		SH319_HUMAN (189-261): 2.12e-13: 71.4: 35.62
+	Hs
		235483 ABL2_HUMAN (9-543): 9.27e-166: 503: 37.96		VINEX_HUMAN (181-260): 1.77e-09: 59.6: 25.30
+	Ce
		104680 SRC1_CAEEL (1-541): 2.11e-169: 492: 47.02		SRBS1_CAEEL (56-261): 5.11e-13: 70.4: 15.05