Protein: EI2BE
Translation initiation factor eIF2B subunit epsilon (GCD complex subunit GCD6) (Guanine nucleotide exchange factor subunit GCD6) (eIF2B GDP-GTP exchange factor subunit epsilon)

Gene: EI2BE, GCD6
Organism: Saccharomyces cerevisiae S288C
Interactions: 85
UniProt ID: P32501

Gene Ontology (top 5):
GO:0002183 - cytoplasmic translational initiation
GO:0003743 - translation initiation factor activity
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

738573

EI2BB
Translation initiation factor eIF2B subunit beta

14

15

Small-scale

0.983

High

555297

EI2BD
Translation initiation factor eIF2B subunit delta

12

15

Small-scale

0.981

High

575317

EI2BA
Translation initiation factor eIF2B subunit alpha

10

15

Small-scale

0.973

High

738585

IF5
Eukaryotic translation initiation factor 5

2

12

Small-scale

0.768

High

478402

EI2BG
Translation initiation factor eIF2B subunit gamma

16

15

Small-scale

0.763

High

478600

IF2B
Eukaryotic translation initiation factor 2 subunit beta

12

5

Small-scale

0.758

High

632870

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

11

1

Small-scale

0.757

High

737691

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

9

8

Small-scale

0.752

High

738572

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

17

High-throughput

0.665

High

438650

SC160
Protein SCP160

2

1

High-throughput

0.588

High

738597

IST1
Vacuolar protein sorting-associated protein IST1

2

1

High-throughput

0.588

High

670476

SIS1
Protein SIS1

2

7

High-throughput

0.571

High

738583

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

2

1

Small-scale

0.560

High

666671

GRR1
SCF E3 ubiquitin ligase complex F-box protein GRR1

1

1

High-throughput

0.536

High

721777

XPO1
Exportin-1

1

7

High-throughput

0.536

High

738053

MKK2
MAP kinase kinase MKK2/SSP33

1

4

High-throughput

0.536

High

738603

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

3

High-throughput

0.536

High

738607

GCN5
Histone acetyltransferase GCN5

1

1

High-throughput

0.536

High

738612

CYK3
Cytokinesis protein 3

1

0

High-throughput

0.518

High

644889

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

3

High-throughput

0.489

High

656947

BUR1
Serine/threonine-protein kinase BUR1

1

1

High-throughput

0.489

High

738582

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

5

High-throughput

0.489

High

738596

FMP48
Probable serine/threonine-protein kinase FMP48

1

1

High-throughput

0.489

High

738600

MPS1
Serine/threonine-protein kinase MPS1

1

3

High-throughput

0.489

High

738615

YGK3
Glycogen synthase kinase-3 homolog YGK3

1

2

High-throughput

0.489

High

738575

TOR2
Serine/threonine-protein kinase TOR2

1

4

High-throughput

0.481

High

738579

TOR1
Serine/threonine-protein kinase TOR1

1

3

High-throughput

0.481

High

738577

SUI1
Eukaryotic translation initiation factor eIF-1

1

0

Small-scale

0.480

High

149653

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.479

High

410003

RL25
Large ribosomal subunit protein uL23

1

2

High-throughput

0.479

High

430809

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

4

Small-scale

0.479

High

433520

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.479

High

434930

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

435849

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.479

High

436354

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

5

High-throughput

0.479

High

441783

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.479

High

454940

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.479

High

502920

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.479

High

504104

RL31A
Large ribosomal subunit protein eL31A

1

2

High-throughput

0.479

High

512325

RS6A
Small ribosomal subunit protein eS6A

1

2

High-throughput

0.479

High

512889

RS8A
Small ribosomal subunit protein eS8A

1

2

High-throughput

0.479

High

514523

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

674488

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.479

High

679488

CDC48
Cell division control protein 48

1

2

High-throughput

0.479

High

689335

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.479

High

709631

BMH1
Protein BMH1

1

1

High-throughput

0.479

High

738576

RSSA1
Small ribosomal subunit protein uS2A

1

3

High-throughput

0.479

High

738578

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.479

High

738580

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

738581

GBLP
Small ribosomal subunit protein RACK1

1

3

High-throughput

0.479

High

738586

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.479

High

738589

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.479

High

738591

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

2

High-throughput

0.479

High

738594

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.479

High

738599

APJ1
J domain-containing protein APJ1

1

6

High-throughput

0.479

High

738604

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.479

High

738606

TOM1
E3 ubiquitin-protein ligase TOM1

1

4

High-throughput

0.479

High

738608

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

1

High-throughput

0.479

High

738611

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.479

High

738613

MCA1
Metacaspase-1

1

1

High-throughput

0.479

High

738614

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.479

High

738605

ESP1
Separin

1

0

High-throughput

0.458

High

394359

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.445

High

523376

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.445

High

675820

MAS5
Mitochondrial protein import protein MAS5

1

6

High-throughput

0.445

High

738574

HSP7F
Heat shock protein homolog SSE1

1

8

High-throughput

0.445

High

738590

SSB2
Ribosome-associated molecular chaperone SSB2

1

5

High-throughput

0.445

High

381955

H4
Histone H4

1

1

High-throughput

0.437

High

647052

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

3

High-throughput

0.437

High

682209

SPB4
ATP-dependent rRNA helicase SPB4

1

2

High-throughput

0.437

High

706521

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

738602

H3
Histone H3

1

1

High-throughput

0.437

High

738610

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

2

High-throughput

0.437

High

738588

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.426

High

738592

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.426

High

738587

SPT8
SAGA complex subunit SPT8

1

1

High-throughput

0.407

High

738595

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

1

High-throughput

0.407

High

738609

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

1

High-throughput

0.407

High

738616

RUVB2
RuvB-like protein 2

1

3

High-throughput

0.407

High

613795

SPO7
Sporulation-specific protein SPO7

2

0

High-throughput

0.307

High

738593

NOP9
Nucleolar protein 9

1

0

High-throughput

0.279

Low

738601

ACT
Actin

1

0

High-throughput

0.269

Low

738598

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

Small-scale

0.249

Low

738584

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025