HitPredict

Interactor 1: YES (P07947)
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Gene: YES1

Interactor 2: PKHA7 (Q6IQ23)
Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7)
Gene: PLEKHA7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	28877994
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PH~SH3_1
Common GO terms	GO:0005813 - centrosome GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 543 Hs			1 1121
+	Hs
		411764 LCK_HUMAN (83-541): 0: 540: 60.78		PKHA7_HUMAN (1-1121): 2.81e-180: 560: 100.00
+	Hs
		433831 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		PKHA7_HUMAN (1-1121): 2.81e-180: 560: 100.00
+	Hs
		411861 LCK_HUMAN (83-541): 0: 540: 60.78		PKHA5_HUMAN (11-1074): 3.5e-95: 330: 29.45
+	Hs
		434015 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		PKHA5_HUMAN (11-1074): 3.5e-95: 330: 29.45
+	Hs
		433300 YES_HUMAN (1-543): 0: 617: 100.00		AFAD_HUMAN (329-1063): 1.33e-45: 182: 11.19
+	Hs
		522873 SRC_HUMAN (1-543): 0: 601: 74.22		AFAD_HUMAN (329-1063): 1.33e-45: 182: 11.19
+	Hs
		411897 LCK_HUMAN (83-541): 0: 540: 60.78		PKHA6_HUMAN (107-951): 1.85e-57: 218: 27.16
+	Hs
		454848 FGR_HUMAN (1-542): 0: 562: 67.10		SMUF1_HUMAN (4-213): 3.11e-48: 187: 18.58
+	Hs
		412353 FYN_HUMAN (1-543): 0: 582: 72.16		PKHA4_HUMAN (113-465): 8.31e-38: 154: 28.84
+	Hs
		411864 LCK_HUMAN (83-541): 0: 540: 60.78		SMUF1_HUMAN (4-213): 3.11e-48: 187: 18.58
+	Hs
		433282 YES_HUMAN (1-543): 0: 617: 100.00		NEDD4_HUMAN (11-95): 1.03e-15: 84.6: 24.17
+	Hs
		433666 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		AFAD_HUMAN (329-1063): 1.33e-45: 182: 11.19
+	Hs
		411856 LCK_HUMAN (83-541): 0: 540: 60.78		PKHA4_HUMAN (113-465): 8.31e-38: 154: 28.84
+	Hs
		522850 SRC_HUMAN (1-543): 0: 601: 74.22		NEDD4_HUMAN (11-95): 1.03e-15: 84.6: 24.17
+	Hs
		412307 FYN_HUMAN (1-543): 0: 582: 72.16		ITCH_HUMAN (40-305): 7.41e-17: 88.1: 14.49
+	Hs
		434009 LYN_HUMAN (1-541): 3.82e-179: 515: 53.69		PKHA4_HUMAN (113-465): 8.31e-38: 154: 28.84
+	Hs
		412081 FYN_HUMAN (1-543): 0: 582: 72.16		NEDD4_HUMAN (11-95): 1.03e-15: 84.6: 24.17
+	Hs
		789085 ABL2_HUMAN (9-543): 9.27e-166: 503: 37.96		NED4L_HUMAN (59-486): 2.54e-26: 118: 12.47
+	Hs
		789045 ABL2_HUMAN (9-543): 9.27e-166: 503: 37.96		NEDD4_HUMAN (11-95): 1.03e-15: 84.6: 24.17
+	Hs
		337392 ABL1_HUMAN (41-543): 5.93e-161: 489: 39.10		NEDD4_HUMAN (11-95): 1.03e-15: 84.6: 24.17