HitPredict

Interactor 1: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Interactor 2: EPOR (P19235)
Erythropoietin receptor (EPO-R)
Gene: EPOR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	9573010
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~fn3, SH2~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0008284 - positive regulation of cell population proliferation
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 512 Hs			1 508
+	Mm
		540265 LYN_MOUSE (1-512): 0: 612: 96.09		EPOR_MOUSE (1-508): 7.16e-140: 414: 81.69
+	Hs
		522759 SRC_HUMAN (1-510): 0: 580: 51.97		EPOR_HUMAN (1-508): 8.71e-145: 427: 100.00
+	Hs
		411578 LCK_HUMAN (1-512): 0: 582: 63.62		IL2RB_HUMAN (17-488): 2.49e-64: 220: 17.52
+	Hs
		433961 LYN_HUMAN (1-512): 0: 611: 100.00		CSF3R_HUMAN (14-425): 2.42e-50: 186: 13.92
+	Hs
		411991 FYN_HUMAN (1-510): 0: 576: 54.12		IL7RA_HUMAN (109-477): 4.76e-65: 219: 15.65
+	Hs
		442875 HCK_HUMAN (1-512): 0: 595: 70.70		CSF3R_HUMAN (14-425): 2.42e-50: 186: 13.92
+	Mm
		435879 HCK_MOUSE (1-512): 0: 592: 69.92		CSF3R_MOUSE (14-399): 4.44e-42: 162: 15.08
+	Mm
		411919 LCK_MOUSE (1-512): 0: 591: 63.81		CSF3R_MOUSE (14-399): 4.44e-42: 162: 15.08
+	Hs
		560468 TEC_HUMAN (35-505): 1.09e-160: 472: 35.48		PRLR_HUMAN (40-499): 4.21e-85: 276: 18.03
+	Hs
		412028 FYN_HUMAN (1-510): 0: 576: 54.12		IL3RA_HUMAN (37-316): 4.98e-41: 153: 20.00
+	Hs
		412037 FYN_HUMAN (1-510): 0: 576: 54.12		EPHA8_HUMAN (2-369): 1.81e-38: 152: 13.80
+	Hs
		442787 HCK_HUMAN (1-512): 0: 595: 70.70		IL6RB_HUMAN (64-483): 1.74e-23: 106: 12.72
+	Hs
		433612 LYN_HUMAN (1-512): 0: 611: 100.00		IL3RB_HUMAN (17-244): 4.61e-09: 61.2: 14.34
+	Hs
		411565 LCK_HUMAN (1-512): 0: 582: 63.62		PTPRF_HUMAN (8-269): 5.2e-13: 73.9: 16.31
+	Hs
		411959 FYN_HUMAN (1-510): 0: 576: 54.12		PTPRF_HUMAN (8-269): 5.2e-13: 73.9: 16.31
+	Mm
		56907 FYN_MOUSE (1-510): 0: 576: 53.93		PTPRF_MOUSE (6-234): 1.46e-11: 69.2: 17.24
+	Hs
		412051 FYN_HUMAN (1-510): 0: 576: 54.12		IL3RB_HUMAN (17-244): 4.61e-09: 61.2: 14.34
+	Hs
		665469 BTK_HUMAN (2-505): 1.48e-156: 462: 33.86		EPHA8_HUMAN (2-369): 1.81e-38: 152: 13.80