Protein: EBP2
rRNA-processing protein EBP2 (EBNA1-binding protein homolog)

Gene: EBP2
Organism: Saccharomyces cerevisiae S288C
Interactions: 181
UniProt ID: P36049

Gene Ontology (top 5):
GO:0000280 - nuclear division
GO:0003729 - mRNA binding
GO:0005730 - nucleolus
GO:0006364 - rRNA processing
GO:0030687 - preribosome, large subunit precursor

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

780332

BRX1
Ribosome biogenesis protein BRX1

10

10

Small-scale

0.976

High

780249

RPF2
Ribosome biogenesis protein RPF2

11

1

Small-scale

0.973

High

780259

SSF1
Ribosome biogenesis protein SSF1

9

2

Small-scale

0.964

High

780271

NSA2
Ribosome biogenesis protein NSA2

4

1

High-throughput

0.891

High

780317

ERB1
Ribosome biogenesis protein ERB1

3

3

Small-scale

0.839

High

780345

SSF2
Ribosome biogenesis protein SSF2

2

2

High-throughput

0.767

High

780260

RPF1
Ribosome production factor 1

2

1

High-throughput

0.759

High

780291

PESC
Pescadillo homolog

10

1

Small-scale

0.750

High

780339

RRS1
Regulator of ribosome biosynthesis

9

2

Small-scale

0.749

High

682239

SPB4
ATP-dependent rRNA helicase SPB4

7

5

High-throughput

0.738

High

780250

NOP4
Nucleolar protein 4

6

2

Small-scale

0.736

High

780285

NSA1
Ribosome biogenesis protein NSA1

6

1

Small-scale

0.721

High

780278

LOC1
60S ribosomal subunit assembly/export protein LOC1

8

0

Small-scale

0.720

High

780348

DBP10
ATP-dependent RNA helicase DBP10

5

4

High-throughput

0.716

High

780275

RLP7
Ribosome biogenesis protein RLP7

5

2

Small-scale

0.710

High

780331

NOP12
Nucleolar protein 12

5

2

Small-scale

0.705

High

780269

NUG1
Nuclear GTP-binding protein NUG1

5

3

High-throughput

0.704

High

780311

HAS1
ATP-dependent RNA helicase HAS1

5

6

High-throughput

0.704

High

780267

NOC2
Nucleolar complex protein 2

6

0

Small-scale

0.697

High

780258

CIC1
Proteasome-interacting protein CIC1

4

2

High-throughput

0.694

High

780343

NOP53
Ribosome biogenesis protein NOP53

4

2

High-throughput

0.686

High

780324

DBP9
ATP-dependent RNA helicase DBP9

4

3

Small-scale

0.680

High

780247

RRP14
Ribosomal RNA-processing protein 14

5

0

Small-scale

0.675

High

780341

YTM1
Ribosome biogenesis protein YTM1

4

3

Small-scale

0.672

High

637202

PWP1
Periodic tryptophan protein 1

3

4

High-throughput

0.666

High

780346

MAK21
Ribosome biogenesis protein MAK21

3

3

High-throughput

0.658

High

780297

NOP15
Ribosome biogenesis protein 15

3

2

High-throughput

0.650

High

677185

SPB1
27S pre-rRNA

3

1

High-throughput

0.646

High

746610

DRS1
ATP-dependent RNA helicase DRS1

3

5

High-throughput

0.646

High

780252

MAK5
ATP-dependent RNA helicase MAK5

3

5

High-throughput

0.646

High

780263

FKBP3
Peptidyl-prolyl cis-trans isomerase

3

2

High-throughput

0.646

High

780322

FKBP4
FK506-binding protein 4

3

2

High-throughput

0.646

High

780329

NOC3
Nucleolar complex-associated protein 3

3

2

High-throughput

0.646

High

780276

NOP2
25S rRNA

3

3

Small-scale

0.640

High

780309

NOG1
Nucleolar GTP-binding protein 1

3

3

Small-scale

0.640

High

780287

CGR1
rRNA-processing protein CGR1

3

0

High-throughput

0.633

High

780353

RRP12
Ribosomal RNA-processing protein 12

3

0

High-throughput

0.633

High

780284

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

3

0

High-throughput

0.632

High

780246

EBP2
rRNA-processing protein EBP2

3

0

Small-scale

0.625

High

780268

NOP16
Nucleolar protein 16

3

0

High-throughput

0.618

High

780295

NOP13
Nucleolar protein 13

2

1

High-throughput

0.611

High

780254

YBC8
UPF0642 protein YBL028C

2

0

High-throughput

0.588

High

633149

MAK11
Protein MAK11

2

3

Small-scale

0.584

High

763052

RRP1
Ribosomal RNA-processing protein 1

2

2

Small-scale

0.584

High

780318

RRP5
rRNA biogenesis protein RRP5

2

1

Small-scale

0.584

High

780315

PUF6
Pumilio homology domain family member 6

2

1

Small-scale

0.571

High

780282

MPS3
Spindle pole body assembly component MPS3

1

0

Small-scale

0.568

High

410055

RL25
Large ribosomal subunit protein uL23

2

0

Small-scale

0.559

High

780256

ENP1
Essential nuclear protein 1

2

0

High-throughput

0.559

High

780277

UTP10
U3 small nucleolar RNA-associated protein 10

2

0

High-throughput

0.559

High

780312

RRP17
Ribosomal RNA-processing protein 17

2

0

High-throughput

0.559

High

512936

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.553

High

738201

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

1

3

High-throughput

0.541

High

780293

GIS2
Zinc finger protein GIS2

1

1

High-throughput

0.541

High

601018

RL8A
Large ribosomal subunit protein eL8A

2

3

Small-scale

0.535

High

780272

RL34B
Large ribosomal subunit protein eL34B

2

2

Small-scale

0.535

High

419697

H2A2
Histone H2A.2

2

3

High-throughput

0.533

High

523594

HSP71
Heat shock protein SSA1

2

1

High-throughput

0.533

High

666434

DBP2
ATP-dependent RNA helicase DBP2

1

0

High-throughput

0.518

High

780292

BRE5
UBP3-associated protein BRE5

1

0

High-throughput

0.513

High

780306

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

High-throughput

0.513

High

780350

RRP36
rRNA biogenesis protein RRP36

1

0

Small-scale

0.513

High

780290

UTP22
U3 small nucleolar RNA-associated protein 22

1

0

High-throughput

0.493

High

542958

CDC24
Cell division control protein 24

1

1

High-throughput

0.489

High

780302

RL34A
Large ribosomal subunit protein eL34A

1

2

Small-scale

0.481

High

149691

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.479

High

432540

RL7A
Large ribosomal subunit protein uL30A

1

2

High-throughput

0.479

High

433567

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.479

High

512370

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

513667

RL2A
Large ribosomal subunit protein uL2A

1

2

High-throughput

0.479

High

534098

MAK16
Protein MAK16

1

2

High-throughput

0.479

High

569968

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

688999

RL16A
Large ribosomal subunit protein uL13A

1

2

High-throughput

0.479

High

689194

RL16B
Large ribosomal subunit protein uL13B

1

2

High-throughput

0.479

High

750058

MRT4
Ribosome assembly factor MRT4

1

1

High-throughput

0.479

High

780248

DBP7
ATP-dependent RNA helicase DBP7

1

5

High-throughput

0.479

High

780264

DHH1
ATP-dependent RNA helicase DHH1

1

1

High-throughput

0.479

High

780281

MTR4
ATP-dependent RNA helicase DOB1

1

2

Small-scale

0.479

High

780286

LSG1
Large subunit GTPase 1

1

3

Small-scale

0.479

High

780288

RL26B
Large ribosomal subunit protein uL24B

1

2

High-throughput

0.479

High

780299

RCM1
25S rRNA

1

3

High-throughput

0.479

High

780310

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.479

High

780323

JIP5
WD repeat-containing protein JIP5

1

2

High-throughput

0.479

High

780327

NOC4
Nucleolar complex protein 4

1

3

High-throughput

0.479

High

780330

RLP24
Ribosome biogenesis protein RLP24

1

1

High-throughput

0.479

High

780333

REXO4
RNA exonuclease 4

1

1

High-throughput

0.479

High

780340

NIP7
60S ribosome subunit biogenesis protein NIP7

1

1

High-throughput

0.479

High

780344

RRP6
Exosome complex exonuclease RRP6

1

1

High-throughput

0.479

High

780351

NOP58
Nucleolar protein 58

1

2

High-throughput

0.479

High

780352

IF6
Eukaryotic translation initiation factor 6

1

2

High-throughput

0.479

High

511771

RS24A
Small ribosomal subunit protein eS24A

1

1

High-throughput

0.470

High

656957

BUR1
Serine/threonine-protein kinase BUR1

1

1

High-throughput

0.470

High

780325

RGA2
Rho-type GTPase-activating protein 2

1

2

High-throughput

0.470

High

780255

FL2D
Protein MUM2

1

0

High-throughput

0.460

High

780335

ULS1
ATP-dependent helicase ULS1

1

0

Small-scale

0.460

High

435890

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

441836

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

670571

SIS1
Protein SIS1

1

0

High-throughput

0.458

High

672872

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.458

High

674543

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

677348

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.458

High

677915

YCQ6
Uncharacterized protein YCR016W

1

0

High-throughput

0.458

High

689379

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

726931

HS104
Heat shock protein 104

1

0

High-throughput

0.458

High

751373

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

High-throughput

0.458

High

758197

URB1
Nucleolar pre-ribosomal-associated protein 1

1

0

Small-scale

0.458

High

780257

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

780262

RIX1
Pre-rRNA-processing protein RIX1

1

0

Small-scale

0.458

High

780289

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.458

High

780296

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

Small-scale

0.458

High

780298

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

780313

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.458

High

780316

UTP14
U3 small nucleolar RNA-associated protein 14

1

0

High-throughput

0.458

High

780326

RRP15
Ribosomal RNA-processing protein 15

1

0

High-throughput

0.458

High

544450

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

154151

RL36B
Large ribosomal subunit protein eL36B

1

2

Small-scale

0.439

High

434149

RL36A
Large ribosomal subunit protein eL36A

1

2

Small-scale

0.439

High

646017

KIN3
Serine/threonine-protein kinase KIN3

1

1

High-throughput

0.439

High

777038

BDF1
Bromodomain-containing factor 1

1

3

High-throughput

0.439

High

381066

H2B1
Histone H2B.1

1

3

High-throughput

0.437

High

419405

H2A1
Histone H2A.1

1

3

High-throughput

0.437

High

436379

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

1

High-throughput

0.437

High

454988

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.437

High

504150

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

684682

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.437

High

706774

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

708715

TF3B
Transcription factor IIIB 70 kDa subunit

1

1

High-throughput

0.437

High

712539

RL8B
Large ribosomal subunit protein eL8B

1

3

High-throughput

0.437

High

780251

GBLP
Small ribosomal subunit protein RACK1

1

4

High-throughput

0.437

High

780301

H3
Histone H3

1

3

High-throughput

0.437

High

780308

RL21A
Large ribosomal subunit protein eL21A

1

1

High-throughput

0.437

High

780314

VMS1
tRNA endonuclease VMS1

1

1

High-throughput

0.437

High

780304

SEN1
Helicase SEN1

1

0

Small-scale

0.426

High

780336

TMA16
Translation machinery-associated protein 16

2

0

High-throughput

0.310

High

780274

DSN1
Kinetochore-associated protein DSN1

2

0

High-throughput

0.305

High

780347

SIZ2
E3 SUMO-protein ligase SIZ2

1

0

Small-scale

0.288

High

721840

XPO1
Exportin-1

1

0

High-throughput

0.279

Low

780294

ELOA1
Elongin-A

1

0

High-throughput

0.279

Low

780305

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

1

0

High-throughput

0.279

Low

780337

HRK1
Serine/threonine-protein kinase HRK1

1

0

High-throughput

0.279

Low

780266

OAF1
Oleate-activated transcription factor 1

1

0

High-throughput

0.269

Low

780321

PDP3
NuA3 HAT complex component PDP3

1

0

High-throughput

0.269

Low

780342

THP3
Protein THP3

1

0

High-throughput

0.269

Low

550646

SIR4
Regulatory protein SIR4

1

0

Small-scale

0.265

Low

477548

MYO1
Myosin-1

1

0

High-throughput

0.251

Low

672397

STE50
Protein STE50

1

0

High-throughput

0.251

Low

677748

STP22
Suppressor protein STP22 of temperature-sensitive alpha-factor receptor and arginine permease

1

0

High-throughput

0.251

Low

735612

SMY1
Kinesin-related protein SMY1

1

0

High-throughput

0.251

Low

749659

TYE7
Transcription factor TYE7

1

0

High-throughput

0.251

Low

780253

RTG3
Retrograde regulation protein 3

1

0

High-throughput

0.251

Low

780261

WSS1
DNA-dependent metalloprotease WSS1

1

0

Small-scale

0.251

Low

780270

TSC11
Target of rapamycin complex 2 subunit TSC11

1

0

High-throughput

0.251

Low

780279

TAF1
Transcription initiation factor TFIID subunit 1

1

0

High-throughput

0.251

Low

780280

STB2
Protein STB2

1

0

High-throughput

0.251

Low

780319

HOB2
Protein YPR117W

1

0

High-throughput

0.251

Low

780349

ERP3
Protein ERP3

1

0

High-throughput

0.251

Low

364470

CDK1
Cyclin-dependent kinase 1

1

0

High-throughput

0.249

Low

383631

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

434999

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.249

Low

502974

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

514571

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

558676

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

594312

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

Small-scale

0.249

Low

644907

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

0

High-throughput

0.249

Low

646369

RAD53
Serine/threonine-protein kinase RAD53

1

0

High-throughput

0.249

Low

679568

CDC48
Cell division control protein 48

1

0

High-throughput

0.249

Low

734932

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

747288

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.249

Low

753295

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

778256

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

780265

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

780273

ULP2
Ubiquitin-like-specific protease 2

1

0

High-throughput

0.249

Low

780283

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

780300

ORC1
Origin recognition complex subunit 1

1

0

High-throughput

0.249

Low

780303

NUM1
Nuclear migration protein NUM1

1

0

High-throughput

0.249

Low

780307

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

780320

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

780328

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

780334

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

780338

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025