HitPredict

Interactor 1: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Interactor 2: MUC18 (P43121)
Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146)
Gene: MCAM

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	34079125, 38117590
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0030335 - positive regulation of cell migration
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 512 Hs			1 646
+	Hs
		522843 SRC_HUMAN (1-510): 0: 580: 51.97		MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00
+	Hs
		412074 FYN_HUMAN (1-510): 0: 576: 54.12		MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00
+	Hs
		433279 YES_HUMAN (1-510): 0: 572: 54.26		MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00
+	Hs
		434019 LYN_HUMAN (1-512): 0: 611: 100.00		ROBO2_HUMAN (1-646): 1.16e-96: 325: 14.69
+	Hs
		433742 LYN_HUMAN (1-512): 0: 611: 100.00		PTK7_HUMAN (17-627): 1.64e-70: 249: 12.68
+	Hs
		297881 FYN_HUMAN (1-510): 0: 576: 54.12		NFASC_HUMAN (35-643): 5.15e-62: 225: 13.39
+	Hs
		297880 ABL1_HUMAN (32-509): 9.04e-172: 516: 37.88		NFASC_HUMAN (35-643): 5.15e-62: 225: 13.39
+	Hs
		433947 LYN_HUMAN (1-512): 0: 611: 100.00		KIRR1_HUMAN (240-644): 1.88e-28: 123: 15.77
+	Hs
		434111 LYN_HUMAN (1-512): 0: 611: 100.00		ROBO1_HUMAN (17-271): 4.39e-21: 100: 14.29
+	Dm
		219802 ABL_DROME (3-508): 3.3e-170: 523: 36.36		O44924_DROME (337-636): 3.76e-37: 151: 12.35