HitPredict

Interactor 1: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Interactor 2: ANR54 (Q6NXT1)
Ankyrin repeat domain-containing protein 54 (Lyn-interacting ankyrin repeat protein)
Gene: ANKRD54

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	32707033, 36736316, 23503679
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 512 Hs			1 300
+	Mm
		639458 LYN_MOUSE (1-512): 0: 612: 96.09		ANR54_MOUSE (1-300): 4.51e-70: 220: 92.00
+	Hs
		433730 LYN_HUMAN (1-512): 0: 611: 100.00		ANK3_HUMAN (83-297): 6.75e-61: 211: 20.31
+	Hs
		433701 LYN_HUMAN (1-512): 0: 611: 100.00		ANK2_HUMAN (82-297): 7.44e-60: 208: 19.62
+	Hs
		434071 LYN_HUMAN (1-512): 0: 611: 100.00		KDIS_HUMAN (1-260): 6.37e-60: 208: 15.89
+	Hs
		523028 SRC_HUMAN (1-510): 0: 580: 51.97		ANR54_HUMAN (1-300): 7.42e-69: 217: 100.00
+	Hs
		411697 LCK_HUMAN (1-512): 0: 582: 63.62		ANK3_HUMAN (83-297): 6.75e-61: 211: 20.31
+	Hs
		411885 LCK_HUMAN (1-512): 0: 582: 63.62		KDIS_HUMAN (1-260): 6.37e-60: 208: 15.89
+	Hs
		433389 YES_HUMAN (1-510): 0: 572: 54.26		ANR54_HUMAN (1-300): 7.42e-69: 217: 100.00
+	Hs
		846484 BLK_HUMAN (1-512): 0: 544: 60.00		ANR54_HUMAN (1-300): 7.42e-69: 217: 100.00
+	Hs
		434072 LYN_HUMAN (1-512): 0: 611: 100.00		ANR50_HUMAN (124-297): 4.84e-39: 148: 21.17
+	Mm
		976833 ITK_MOUSE (33-503): 1.69e-160: 471: 36.80		ANR54_MOUSE (1-300): 4.51e-70: 220: 92.00
+	Hs
		788998 TEC_HUMAN (35-505): 1.09e-160: 472: 35.48		ANR54_HUMAN (1-300): 7.42e-69: 217: 100.00
+	Hs
		986383 BTK_HUMAN (2-505): 1.48e-156: 462: 33.86		ANR54_HUMAN (1-300): 7.42e-69: 217: 100.00
+	Hs
		337406 ABL1_HUMAN (32-509): 9.04e-172: 516: 37.88		DAPK1_HUMAN (103-298): 1.54e-38: 146: 19.19
+	Dm
		337696 SRC64_DROME (20-510): 3.4e-178: 513: 43.91		TNKS_DROME (24-295): 3.24e-30: 121: 15.83