Protein: ARX1
Probable metalloprotease ARX1 (EC 3.-.-.-) (Associated with ribosomal export complex protein 1)

Gene: ARX1
Organism: Saccharomyces cerevisiae S288C
Interactions: 209
UniProt ID: Q03862

Gene Ontology (top 5):
GO:0000055 - ribosomal large subunit export from nucleus
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

798510

REI1
Cytoplasmic 60S subunit biogenesis factor REI1

22

1

Small-scale

0.765

High

1039619

NOG1
Nucleolar GTP-binding protein 1

20

2

Small-scale

0.763

High

923194

NOG2
Nucleolar GTP-binding protein 2

18

5

Small-scale

0.762

High

1044243

IF6
Eukaryotic translation initiation factor 6

15

1

Small-scale

0.760

High

570130

RL3
Large ribosomal subunit protein uL3

14

1

Small-scale

0.759

High

816893

NUG1
Nuclear GTP-binding protein NUG1

13

5

Small-scale

0.756

High

673588

NLE1
Ribosome assembly protein 4

12

2

Small-scale

0.755

High

1044227

RLP24
Ribosome biogenesis protein RLP24

12

3

Small-scale

0.753

High

917683

LSG1
Large subunit GTPase 1

9

5

Small-scale

0.752

High

750139

MRT4
Ribosome assembly factor MRT4

10

3

Small-scale

0.750

High

745105

AFG2
ATPase family gene 2 protein

8

1

Small-scale

0.749

High

684830

RL5
Large ribosomal subunit protein uL18

9

3

Small-scale

0.748

High

827595

RLP7
Ribosome biogenesis protein RLP7

9

3

Small-scale

0.748

High

427429

RLA0
Large ribosomal subunit protein uL10

8

3

Small-scale

0.747

High

806164

NMD3
60S ribosomal export protein NMD3

29

0

Small-scale

0.735

High

1044247

MEX67
mRNA export factor MEX67

16

0

Small-scale

0.729

High

918975

PESC
Pescadillo homolog

16

0

Small-scale

0.728

High

818270

NSA2
Ribosome biogenesis protein NSA2

12

0

Small-scale

0.725

High

864188

ALB1
Ribosome biogenesis protein ALB1

11

0

Small-scale

0.725

High

919553

SDA1
Protein SDA1

11

0

Small-scale

0.724

High

806651

RIX1
Pre-rRNA-processing protein RIX1

11

0

Small-scale

0.723

High

1044228

BUD20
Bud site selection protein 20

10

0

Small-scale

0.723

High

1044238

NOP53
Ribosome biogenesis protein NOP53

12

0

Small-scale

0.722

High

515317

RL35A
Large ribosomal subunit protein uL29A

6

2

Small-scale

0.719

High

782432

RPF2
Ribosome biogenesis protein RPF2

10

0

Small-scale

0.719

High

1036128

PVH1
Tyrosine-protein phosphatase YVH1

10

0

Small-scale

0.717

High

410318

RL25
Large ribosomal subunit protein uL23

6

1

Small-scale

0.717

High

803924

CIC1
Proteasome-interacting protein CIC1

9

0

Small-scale

0.716

High

758050

MTR2
mRNA transport regulator MTR2

8

0

Small-scale

0.709

High

734725

IMB3
Importin subunit beta-3

5

1

Small-scale

0.706

High

531873

RL4A
Large ribosomal subunit protein uL4A

5

3

Small-scale

0.702

High

1044237

MDN1
Midasin

6

0

Small-scale

0.695

High

924244

IPI3
Pre-rRNA-processing protein IPI3

4

2

Small-scale

0.686

High

689124

RL16A
Large ribosomal subunit protein uL13A

4

3

Small-scale

0.676

High

924838

NOP15
Ribosome biogenesis protein 15

3

3

High-throughput

0.662

High

601120

RL8A
Large ribosomal subunit protein eL8A

6

2

Small-scale

0.658

High

1037980

NU116
Nucleoporin NUP116/NSP116

3

7

Small-scale

0.658

High

885077

RL4B
Large ribosomal subunit protein uL4B

3

3

Small-scale

0.656

High

1037956

NU100
Nucleoporin NUP100/NSP100

5

7

Small-scale

0.648

High

819684

SSB2
Ribosome-associated molecular chaperone SSB2

3

5

High-throughput

0.643

High

513405

RL23B
Large ribosomal subunit protein uL14B

3

1

Small-scale

0.640

High

689277

RL16B
Large ribosomal subunit protein uL13B

3

3

Small-scale

0.640

High

763260

SQT1
Ribosome assembly protein SQT1

3

3

Small-scale

0.640

High

792227

GBLP
Small ribosomal subunit protein RACK1

3

6

High-throughput

0.640

High

835881

RL10
Large ribosomal subunit protein uL16

3

2

Small-scale

0.640

High

525026

HSP71
Heat shock protein SSA1

3

4

High-throughput

0.633

High

924056

JJJ1
J protein JJJ1

3

1

Small-scale

0.633

High

805011

IPI1
Pre-rRNA-processing protein IPI1

3

0

Small-scale

0.628

High

817287

ARB1
ABC transporter ATP-binding protein ARB1

3

0

Small-scale

0.616

High

433832

RL26A
Large ribosomal subunit protein uL24A

4

3

Small-scale

0.613

High

432688

RL7A
Large ribosomal subunit protein uL30A

2

3

High-throughput

0.611

High

924322

NOP13
Nucleolar protein 13

2

3

High-throughput

0.611

High

1044212

ARX1
Probable metalloprotease ARX1

3

0

Small-scale

0.609

High

918044

CGR1
rRNA-processing protein CGR1

3

0

Small-scale

0.606

High

634276

NUP1
Nucleoporin NUP1

2

3

Small-scale

0.602

High

1031042

NOP3
Serine/arginine

2

3

Small-scale

0.601

High

712660

RL8B
Large ribosomal subunit protein eL8B

3

2

High-throughput

0.599

High

511279

RL20B
Large ribosomal subunit protein eL20B

3

1

High-throughput

0.585

High

511481

RL43B
Large ribosomal subunit protein eL43B

3

1

Small-scale

0.585

High

513763

RL2A
Large ribosomal subunit protein uL2A

3

2

High-throughput

0.585

High

513565

RL1A
Large ribosomal subunit protein uL1A

2

2

Small-scale

0.584

High

677235

SPB1
27S pre-rRNA

2

2

High-throughput

0.584

High

1044241

DBP10
ATP-dependent RNA helicase DBP10

2

1

High-throughput

0.584

High

1044246

RL11B
Large ribosomal subunit protein uL5B

2

3

Small-scale

0.584

High

436150

RS13
Small ribosomal subunit protein uS15

2

1

High-throughput

0.571

High

738112

MYO4
Myosin-4

2

0

High-throughput

0.563

High

813717

ECM1
Shuttling pre-60S factor ECM1

2

0

Small-scale

0.559

High

844594

UTP10
U3 small nucleolar RNA-associated protein 10

2

0

High-throughput

0.559

High

154221

RL36B
Large ribosomal subunit protein eL36B

2

1

High-throughput

0.558

High

1038393

RL21A
Large ribosomal subunit protein eL21A

2

3

Small-scale

0.558

High

1044231

TMA16
Translation machinery-associated protein 16

2

0

High-throughput

0.547

High

1044233

RRS1
Regulator of ribosome biosynthesis

2

0

High-throughput

0.547

High

886179

NUP42
Nucleoporin NUP42

2

4

Small-scale

0.543

High

792932

ANM1
Protein arginine N-methyltransferase 1

1

1

Small-scale

0.541

High

813608

ERP2
Protein ERP2

2

3

High-throughput

0.537

High

403643

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

4

Small-scale

0.536

High

569855

RL30
Large ribosomal subunit protein eL30

1

2

High-throughput

0.536

High

722228

XPO1
Exportin-1

1

4

High-throughput

0.536

High

1044221

FKBP4
FK506-binding protein 4

1

5

High-throughput

0.536

High

504396

RL31A
Large ribosomal subunit protein eL31A

2

1

High-throughput

0.533

High

514057

RL18B
Large ribosomal subunit protein eL18B

2

2

High-throughput

0.533

High

1044232

RS10A
Small ribosomal subunit protein eS10A

2

3

High-throughput

0.533

High

515164

RL19B
Large ribosomal subunit protein eL19

2

3

Small-scale

0.521

High

918327

RL26B
Large ribosomal subunit protein uL24B

2

3

Small-scale

0.521

High

917470

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

0

High-throughput

0.513

High

1044236

NIP7
60S ribosome subunit biogenesis protein NIP7

1

0

High-throughput

0.513

High

924719

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.504

High

577344

NSP1
Nucleoporin NSP1

1

5

Small-scale

0.501

High

738506

NUP2
Nucleoporin NUP2

1

2

Small-scale

0.501

High

825175

NU159
Nucleoporin NUP159

1

4

Small-scale

0.501

High

1035268

NUP49
Nucleoporin NUP49/NSP49

1

4

Small-scale

0.501

High

438223

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.493

High

813655

NUP60
Nucleoporin NUP60

1

0

Small-scale

0.480

High

149938

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.479

High

415048

RL39
Large ribosomal subunit protein eL39

1

2

High-throughput

0.479

High

433283

RL17A
Large ribosomal subunit protein uL22A

1

2

High-throughput

0.479

High

435335

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

436506

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

2

High-throughput

0.479

High

442094

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

503952

RL27B
Large ribosomal subunit protein eL27B

1

3

High-throughput

0.479

High

509923

RL40A
Ubiquitin-ribosomal protein eL40A fusion protein [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40A

1

1

High-throughput

0.479

High

512628

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

514818

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

637274

PWP1
Periodic tryptophan protein 1

1

3

Small-scale

0.479

High

645521

XRN1
5'-3' exoribonuclease 1

1

1

Small-scale

0.479

High

674816

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

689642

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.479

High

708070

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

735551

IRE1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

1

High-throughput

0.479

High

778516

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

781257

RL14A
Large ribosomal subunit protein eL14A

1

2

High-throughput

0.479

High

792569

RL32
Large ribosomal subunit protein eL32

1

1

High-throughput

0.479

High

802370

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

803434

RL14B
Large ribosomal subunit protein eL14B

1

2

High-throughput

0.479

High

817851

GLE2
mRNA export factor GLE2

1

2

Small-scale

0.479

High

817942

IMB4
Importin subunit beta-4

1

1

High-throughput

0.479

High

850186

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

2

High-throughput

0.479

High

863873

RL17B
Large ribosomal subunit protein uL22B

1

2

High-throughput

0.479

High

864508

MTR4
ATP-dependent RNA helicase DOB1

1

3

Small-scale

0.479

High

874230

TRF5
Poly(A) RNA polymerase protein 1

1

1

Small-scale

0.479

High

874509

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

879840

RL37A
Large ribosomal subunit protein eL37A

1

1

High-throughput

0.479

High

902698

RL37B
Large ribosomal subunit protein eL37B

1

1

High-throughput

0.479

High

922176

PAP2
Poly(A) RNA polymerase protein 2

1

1

Small-scale

0.479

High

1018152

RL34A
Large ribosomal subunit protein eL34A

1

2

High-throughput

0.479

High

1033542

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

1042217

TOM1
E3 ubiquitin-protein ligase TOM1

1

1

High-throughput

0.479

High

1043269

HAS1
ATP-dependent RNA helicase HAS1

1

1

High-throughput

0.479

High

1044214

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

1044216

DHR1
Probable ATP-dependent RNA helicase DHR1

1

4

High-throughput

0.479

High

1044217

VMS1
tRNA endonuclease VMS1

1

2

High-throughput

0.479

High

1044220

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

1044223

NOC4
Nucleolar complex protein 4

1

1

High-throughput

0.479

High

1044224

REH1
Cytoplasmic 60S subunit biogenesis factor REH1

1

1

High-throughput

0.479

High

1044225

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.479

High

1044226

NOC3
Nucleolar complex-associated protein 3

1

1

High-throughput

0.479

High

1044229

NOP12
Nucleolar protein 12

1

4

High-throughput

0.479

High

1044239

YRA1
RNA annealing protein YRA1

1

4

High-throughput

0.479

High

1044240

RL7B
Large ribosomal subunit protein uL30B

1

3

High-throughput

0.479

High

558854

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

594549

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

647204

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.458

High

666540

DBP2
ATP-dependent RNA helicase DBP2

1

0

High-throughput

0.458

High

671077

SIS1
Protein SIS1

1

0

High-throughput

0.458

High

677543

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.458

High

735141

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

782180

LAS1
Protein LAS1

1

0

Small-scale

0.458

High

795841

YBC8
UPF0642 protein YBL028C

1

0

High-throughput

0.458

High

803675

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

804651

SSF1
Ribosome biogenesis protein SSF1

1

0

High-throughput

0.458

High

806811

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

809404

STM1
Suppressor protein STM1

1

0

High-throughput

0.458

High

825393

BMT5
25S rRNA

1

0

High-throughput

0.458

High

825630

AIR1
Protein AIR1

1

0

Small-scale

0.458

High

830170

NOP2
25S rRNA

1

0

High-throughput

0.458

High

850009

LOC1
60S ribosomal subunit assembly/export protein LOC1

1

0

Small-scale

0.458

High

864953

NOP9
Nucleolar protein 9

1

0

Small-scale

0.458

High

917550

NSA1
Ribosome biogenesis protein NSA1

1

0

Small-scale

0.458

High

1040548

ESP1
Separin

1

0

High-throughput

0.458

High

1044213

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.458

High

1044215

RRP17
Ribosomal RNA-processing protein 17

1

0

High-throughput

0.458

High

1044218

PUF6
Pumilio homology domain family member 6

1

0

Small-scale

0.458

High

1044219

RQC1
Ribosome quality control complex subunit 1

1

0

High-throughput

0.458

High

1044222

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

1044230

SGO1
Shugoshin

1

0

High-throughput

0.458

High

1044234

RSA1
Ribosome assembly 1 protein

1

0

Small-scale

0.458

High

1044242

NOP58
Nucleolar protein 58

1

0

High-throughput

0.458

High

503431

RL11A
Large ribosomal subunit protein uL5A

1

3

Small-scale

0.445

High

527578

HSP72
Heat shock protein SSA2

1

4

High-throughput

0.445

High

546126

SSB1
Ribosome-associated molecular chaperone SSB1

1

5

High-throughput

0.445

High

579999

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.445

High

592477

VATB
V-type proton ATPase subunit B

1

2

High-throughput

0.445

High

752683

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.445

High

804423

SSZ1
Ribosome-associated complex subunit SSZ1

1

2

High-throughput

0.445

High

816381

HSP7E
Heat shock protein SSC3, mitochondrial

1

3

High-throughput

0.445

High

877979

NUP57
Nucleoporin NUP57

1

4

Small-scale

0.439

High

383878

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.437

High

409779

RL24A
Large ribosomal subunit protein eL24A

1

3

Small-scale

0.437

High

432909

RL9A
Large ribosomal subunit protein uL6A

1

3

High-throughput

0.437

High

433071

RL6B
Large ribosomal subunit protein eL6B

1

3

High-throughput

0.437

High

434080

RL33A
Large ribosomal subunit protein eL33A

1

1

High-throughput

0.437

High

434434

RL15A
Large ribosomal subunit protein eL15A

1

2

High-throughput

0.437

High

434645

RL22A
Large ribosomal subunit protein eL22A

1

1

High-throughput

0.437

High

455243

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.437

High

503220

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

503842

RL27A
Large ribosomal subunit protein eL27A

1

3

High-throughput

0.437

High

513200

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

514356

RL12B
Large ribosomal subunit protein uL11B

1

2

High-throughput

0.437

High

747559

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

753565

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.437

High

812622

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

820955

RL13B
Large ribosomal subunit protein eL13B

1

2

High-throughput

0.437

High

825903

RL34B
Large ribosomal subunit protein eL34B

1

2

High-throughput

0.437

High

902670

RL9B
Large ribosomal subunit protein uL6B

1

3

High-throughput

0.437

High

1036286

RL6A
Large ribosomal subunit protein eL6A

1

3

High-throughput

0.437

High

1044235

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

1044244

RL21B
Large ribosomal subunit protein eL21B

1

3

High-throughput

0.437

High

1044245

RL13A
Large ribosomal subunit protein eL13A

1

2

High-throughput

0.437

High

453771

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

750772

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.426

High

1043590

CLU
Clustered mitochondria protein 1

1

0

High-throughput

0.426

High

743441

MSS4
Protein DSS4

1

0

High-throughput

0.279

Low

511592

RL44B
Large ribosomal subunit protein eL42B

1

0

High-throughput

0.249

Low

515383

RS32B
Small ribosomal subunit protein eS32B

1

0

High-throughput

0.249

Low

738693

EI2BB
Translation initiation factor eIF2B subunit beta

1

0

High-throughput

0.249

Low

1025024

NUM1
Nuclear migration protein NUM1

1

0

High-throughput

0.249

Low

575512

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.232

Low

755162

GCN1
eIF-2-alpha kinase activator GCN1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025