HitPredict

Interactor 1: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Interactor 2: SH2D3 (Q8N5H7)
SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1)
Gene: SH2D3C

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	23503679
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 512 Hs			1 860
+	Rn
		989767 LYN_RAT (1-512): 0: 612: 96.09		SRC_RAT (20-425): 1.35e-61: 219: 13.21
+	Hs
		433216 LYN_HUMAN (1-512): 0: 611: 100.00		YES_HUMAN (81-393): 4.07e-61: 218: 11.78
+	Hs
		433546 LYN_HUMAN (1-512): 0: 611: 100.00		SRC_HUMAN (20-393): 2.03e-60: 216: 12.76
+	Hs
		433535 LYN_HUMAN (1-512): 0: 611: 100.00		FGR_HUMAN (112-393): 2.09e-58: 210: 14.29
+	Hs
		433717 LYN_HUMAN (1-512): 0: 611: 100.00		BTK_HUMAN (24-426): 1.81e-56: 208: 10.49
+	Hs
		442772 HCK_HUMAN (1-512): 0: 595: 70.70		SRC_HUMAN (20-393): 2.03e-60: 216: 12.76
+	Hs
		433653 LYN_HUMAN (1-512): 0: 611: 100.00		BLK_HUMAN (108-394): 1.28e-54: 199: 13.44
+	Hs
		433522 LYN_HUMAN (1-512): 0: 611: 100.00		LYN_HUMAN (132-424): 2.93e-54: 198: 11.39
+	Rn
		989763 LYN_RAT (1-512): 0: 612: 96.09		LYN_RAT (132-394): 4.88e-54: 197: 12.24
+	Hs
		433530 LYN_HUMAN (1-512): 0: 611: 100.00		HCK_HUMAN (91-394): 1.07e-53: 197: 13.71
+	Hs
		411553 LYN_HUMAN (1-512): 0: 611: 100.00		LCK_HUMAN (123-424): 1.07e-53: 196: 10.59
+	Hs
		442813 HCK_HUMAN (1-512): 0: 595: 70.70		BTK_HUMAN (24-426): 1.81e-56: 208: 10.49
+	Mm
		435875 HCK_MOUSE (1-512): 0: 592: 69.92		HCK_MOUSE (92-393): 8.39e-57: 205: 13.27
+	Hs
		442759 HCK_HUMAN (1-512): 0: 595: 70.70		HCK_HUMAN (91-394): 1.07e-53: 197: 13.71
+	Hs
		411559 HCK_HUMAN (1-512): 0: 595: 70.70		LCK_HUMAN (123-424): 1.07e-53: 196: 10.59
+	Hs
		433604 LYN_HUMAN (1-512): 0: 611: 100.00		SHC1_HUMAN (97-322): 5.53e-44: 170: 24.02
+	Mm
		639435 LYN_MOUSE (1-512): 0: 612: 96.09		P85A_MOUSE (202-319): 6.33e-16: 84.3: 22.58
+	Hs
		433595 LYN_HUMAN (1-512): 0: 611: 100.00		P85A_HUMAN (202-319): 6.33e-16: 84.3: 22.58
+	Hs
		442782 HCK_HUMAN (1-512): 0: 595: 70.70		P85A_HUMAN (202-319): 6.33e-16: 84.3: 22.58