HitPredict

Interactor 1: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Interactor 2: GPVI (Q9HCN6)
Platelet glycoprotein VI (GPVI) (Glycoprotein 6)
Gene: GP6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.720

Property	Details
Experiments	11943772, 12594225, 20946164, 19940238, 1715582
Identification Methods	pull down, affinity chromatography technology, anti bait coimmunoprecipitation, phage display
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0009986 - cell surface GO:0045121 - membrane raft GO:0070062 - extracellular exosome
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 512 Hs			1 339
+	Hs
		442886 HCK_HUMAN (1-512): 0: 595: 70.70		GPVI_HUMAN (1-339): 2.78e-74: 234: 100.00
+	Hs
		412364 FYN_HUMAN (1-510): 0: 576: 54.12		GPVI_HUMAN (1-339): 2.78e-74: 234: 100.00
+	Hs
		433481 YES_HUMAN (1-510): 0: 572: 54.26		GPVI_HUMAN (1-339): 2.78e-74: 234: 100.00
+	Mm
		56907 FYN_MOUSE (1-510): 0: 576: 53.93		PTPRF_MOUSE (1-332): 1.64e-52: 188: 14.67
+	Hs
		433581 LYN_HUMAN (1-512): 0: 611: 100.00		FCAR_HUMAN (109-306): 2.82e-26: 107: 17.39
+	Hs
		434111 LYN_HUMAN (1-512): 0: 611: 100.00		ROBO1_HUMAN (108-336): 7.89e-25: 107: 12.81
+	Hs
		411565 LCK_HUMAN (1-512): 0: 582: 63.62		PTPRF_HUMAN (112-324): 5.4e-27: 114: 14.41
+	Hs
		986398 BTK_HUMAN (2-505): 1.48e-156: 462: 33.86		GPVI_HUMAN (1-339): 2.78e-74: 234: 100.00
+	Hs
		411959 FYN_HUMAN (1-510): 0: 576: 54.12		PTPRF_HUMAN (112-324): 5.4e-27: 114: 14.41
+	Mm
		639452 LYN_MOUSE (1-512): 0: 612: 96.09		FCRL5_MOUSE (25-260): 8.91e-13: 70.8: 18.73
+	Hs
		434019 LYN_HUMAN (1-512): 0: 611: 100.00		ROBO2_HUMAN (7-249): 1.05e-12: 71.3: 14.44
+	Mm
		639442 LYN_MOUSE (1-512): 0: 612: 96.09		LIRB3_MOUSE (20-128): 9.17e-09: 58.9: 24.39
+	Mm
		435881 HCK_MOUSE (1-512): 0: 592: 69.92		LIRB3_MOUSE (20-128): 9.17e-09: 58.9: 24.39
+	Hs
		782807 CSK_HUMAN (64-503): 1.5e-171: 493: 38.41		LIRB1_HUMAN (23-302): 5.68e-36: 139: 25.17
+	Hs
		782798 CSK_HUMAN (64-503): 1.5e-171: 493: 38.41		LAIR1_HUMAN (109-224): 6.27e-26: 106: 29.51
+	Dm
		219802 ABL_DROME (3-508): 3.3e-170: 523: 36.36		O44924_DROME (202-327): 1.04e-13: 74.3: 12.31