Protein: ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase (DHQS) (EC 4.2.3.4); 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS); Shikimate kinase (SK) (EC 2.7.1.71); 3-dehydroquinate dehydratase (3-dehydroquinase) (EC 4.2.1.10); Shikimate dehydrogenase (EC 1.1.1.25)]

Gene: ARO1
Organism: Saccharomyces cerevisiae S288C
Interactions: 103
UniProt ID: P08566

Gene Ontology (top 5):
GO:0003866 - 3-phosphoshikimate 1-carboxyvinyltransferase activity
GO:0003855 - 3-dehydroquinate dehydratase activity
GO:0003856 - 3-dehydroquinate synthase activity
GO:0004764 - shikimate 3-dehydrogenase (NADP+) activity
GO:0004765 - shikimate kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

440851

HSC82
ATP-dependent molecular chaperone HSC82

4

1

High-throughput

0.691

High

440931

RUVB2
RuvB-like protein 2

3

1

High-throughput

0.667

High

440855

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

2

0

High-throughput

0.602

High

440887

FHP
Flavohemoprotein

2

0

High-throughput

0.602

High

440900

TCPQ
T-complex protein 1 subunit theta

2

0

High-throughput

0.602

High

440845

SSB1
Ribosome-associated molecular chaperone SSB1

2

1

High-throughput

0.601

High

440910

PRS8
26S proteasome regulatory subunit 8 homolog

2

1

High-throughput

0.601

High

365604

HSP82
ATP-dependent molecular chaperone HSP82

2

1

Small-scale

0.596

High

440858

RAD51
DNA repair protein RAD51

2

0

High-throughput

0.595

High

440912

RUVB1
RuvB-like protein 1

2

1

High-throughput

0.571

High

440896

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

0

High-throughput

0.559

High

440843

HSP72
Heat shock protein SSA2

2

1

High-throughput

0.552

High

440890

SSB2
Ribosome-associated molecular chaperone SSB2

2

1

High-throughput

0.552

High

440844

METK1
S-adenosylmethionine synthase 1

1

1

High-throughput

0.536

High

440876

PRS7
26S proteasome regulatory subunit 7 homolog

1

1

High-throughput

0.536

High

440924

HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1

1

1

High-throughput

0.515

High

343254

TRPG
Multifunctional tryptophan biosynthesis protein [Includes: Anthranilate synthase component 2

1

0

High-throughput

0.513

High

424970

DHE4
NADP-specific glutamate dehydrogenase 1

1

0

High-throughput

0.513

High

440840

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.513

High

440879

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.513

High

440882

KSP1
Serine/threonine-protein kinase KSP1

1

0

High-throughput

0.513

High

440893

MOB1
DBF2 kinase activator protein MOB1

1

0

High-throughput

0.513

High

440895

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.513

High

440897

LSB3
LAS seventeen-binding protein 3

1

0

High-throughput

0.513

High

440909

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

High-throughput

0.513

High

440917

KU80
ATP-dependent DNA helicase II subunit 2

1

0

High-throughput

0.513

High

440930

AHA1
Hsp90 co-chaperone AHA1

1

0

High-throughput

0.513

High

440869

ARP2
Actin-related protein 2

1

1

High-throughput

0.500

High

440868

EF2
Elongation factor 2

1

2

High-throughput

0.489

High

440873

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.489

High

440898

RSSA2
Small ribosomal subunit protein uS2B

1

2

High-throughput

0.489

High

440901

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

0

High-throughput

0.486

High

440856

MEK1
Meiosis-specific serine/threonine-protein kinase MEK1

1

0

High-throughput

0.479

High

440880

IMB2
Importin subunit beta-2

1

0

High-throughput

0.479

High

440870

HOG1
Mitogen-activated protein kinase HOG1

1

3

High-throughput

0.479

High

440908

APJ1
J domain-containing protein APJ1

1

1

High-throughput

0.479

High

440921

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

1

Small-scale

0.479

High

440846

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

440860

SPB4
ATP-dependent rRNA helicase SPB4

1

0

High-throughput

0.458

High

440865

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

440874

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

440883

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

440891

TM108
Protein TMA108

1

0

High-throughput

0.458

High

440899

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.458

High

440902

MTNB
Methylthioribulose-1-phosphate dehydratase

1

0

High-throughput

0.458

High

440907

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

1

0

Small-scale

0.458

High

440911

ESP1
Separin

1

0

High-throughput

0.458

High

440914

MUS81
Crossover junction endonuclease MUS81

1

0

High-throughput

0.458

High

440916

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.458

High

440922

GDE
Glycogen debranching enzyme

1

0

High-throughput

0.458

High

440923

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

440925

SGO1
Shugoshin

1

0

High-throughput

0.458

High

440926

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

440932

CMR1
DNA damage-binding protein CMR1

1

0

High-throughput

0.458

High

440933

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.458

High

440848

EI2BA
Translation initiation factor eIF2B subunit alpha

1

1

High-throughput

0.457

High

440842

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

440859

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.445

High

440872

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

440906

JJJ1
J protein JJJ1

1

1

High-throughput

0.445

High

440928

HSP42
Heat shock protein 42

1

2

High-throughput

0.445

High

440857

SIS1
Protein SIS1

1

1

High-throughput

0.437

High

440863

RL16A
Large ribosomal subunit protein uL13A

1

1

High-throughput

0.437

High

360699

TBB
Tubulin beta chain

1

0

High-throughput

0.426

High

367628

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

399272

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.426

High

440847

DHAS
Aspartate-semialdehyde dehydrogenase

1

0

High-throughput

0.426

High

440852

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.426

High

440853

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.426

High

440854

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

0

High-throughput

0.426

High

440861

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.426

High

440866

HS104
Heat shock protein 104

1

0

High-throughput

0.426

High

440889

HSP7E
Heat shock protein SSC3, mitochondrial

1

0

High-throughput

0.426

High

440892

MET18
DNA repair/transcription protein MET18/MMS19

1

0

High-throughput

0.426

High

440894

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.426

High

440904

RL4B
Large ribosomal subunit protein uL4B

1

0

High-throughput

0.426

High

440919

DYN3
Cytoplasmic dynein intermediate light chain DYN3

1

0

High-throughput

0.426

High

440871

EI2BB
Translation initiation factor eIF2B subunit beta

1

1

High-throughput

0.407

High

440849

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

2

0

High-throughput

0.328

High

440913

RPN9
26S proteasome regulatory subunit RPN9

2

0

High-throughput

0.328

High

440864

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

2

0

High-throughput

0.313

High

440888

ERP2
Protein ERP2

2

0

High-throughput

0.307

High

440839

KEX1
Pheromone-processing carboxypeptidase KEX1

2

0

High-throughput

0.298

High

440862

RFA3
Replication factor A protein 3

1

0

High-throughput

0.279

Low

440877

SPT7
Transcriptional activator SPT7

1

0

High-throughput

0.279

Low

440881

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.279

Low

440929

SWM1
Anaphase-promoting complex subunit SWM1

1

0

High-throughput

0.279

Low

440915

UTP5
U3 small nucleolar RNA-associated protein 5

1

0

High-throughput

0.261

Low

440918

SPC24
Kinetochore protein SPC24

1

0

High-throughput

0.261

Low

356176

H4
Histone H4

1

0

High-throughput

0.249

Low

440875

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

440878

CENPA
Histone H3-like centromeric protein CSE4

1

0

High-throughput

0.249

Low

440884

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.249

Low

440886

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

440903

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

440920

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

440927

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.249

Low

382862

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.232

Low

440841

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.232

Low

440850

SEC63
Protein translocation protein SEC63

1

0

High-throughput

0.232

Low

440867

VPS10
Vacuolar protein sorting/targeting protein VPS10

1

0

High-throughput

0.232

Low

440885

SPT8
Transcription factor SPT8

1

0

High-throughput

0.232

Low

440905

NOG2
Nucleolar GTP-binding protein 2

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024