HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.704

Property	Details
Experiments	28794017, 32062451, 12727845, 15677445
Identification Methods	far western blotting, proximity labelling technology, affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005509 - calcium ion binding GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1114 Hs			1 906
+	Rn
		88770 RET_RAT (1-1114): 0: 1316: 85.29		D3ZV15_RAT (1-883): 0: 833: 89.00
+	Hs
		434308 RET_HUMAN (1-1114): 0: 1295: 100.00		CBLC_HUMAN (42-504): 0: 620: 42.07
+	Hs
		601457 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		610410 ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		337933 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		383609 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		CBL_HUMAN (1-906): 0: 917: 100.00
+	Mm
		610584 EGFR_MOUSE (426-1113): 8.96e-142: 459: 22.83		CBL_MOUSE (1-906): 0: 888: 91.59
+	Rn
		88782 Q9QX70_RAT (426-1113): 1.3e-141: 459: 23.07		D3ZV15_RAT (1-883): 0: 833: 89.00
+	Hs
		338362 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Hs
		339127 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		CBLC_HUMAN (42-504): 0: 620: 42.07
+	Hs
		203204 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		SYNJ1_HUMAN (542-897): 2.72e-14: 79.6: 10.22
+	Hs
		508077 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		MICA3_HUMAN (406-905): 3.1e-14: 79.6: 11.67
+	Hs
		554307 ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43		MUC1_HUMAN (449-906): 3.82e-14: 79.2: 10.58
+	Hs
		508152 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		ASPP1_HUMAN (445-844): 1.47e-10: 67.3: 10.25
+	Hs
		338620 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		MICA3_HUMAN (406-905): 3.1e-14: 79.6: 11.67
+	Hs
		337875 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		MUC1_HUMAN (449-906): 3.82e-14: 79.2: 10.58
+	Hs
		383583 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		MUC1_HUMAN (449-906): 3.82e-14: 79.2: 10.58
+	Hs
		338849 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		ASPP1_HUMAN (445-844): 1.47e-10: 67.3: 10.25
+	Mm
		964562 EGFR_MOUSE (426-1113): 8.96e-142: 459: 22.83		ASPP1_MOUSE (429-870): 1.7e-09: 63.8: 11.96
+	Rn
		94375 FGFR1_RAT (501-1061): 9.97e-146: 459: 32.44		F1M9G7_RAT (544-894): 3.04e-09: 63.4: 11.58