Protein: PWP2
Periodic tryptophan protein 2 homolog

Gene: PWP2
Organism: Homo sapiens
Interactions: 137
UniProt ID: Q15269

Gene Ontology (top 5):
GO:0000028 - ribosomal small subunit assembly
GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0032040 - small-subunit processome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1144757

UTP18
U3 small nucleolar RNA-associated protein 18 homolog

4

18

High-throughput

0.886

High

1144748

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

2

10

High-throughput

0.789

High

1144742

ANLN
Anillin

2

7

High-throughput

0.754

High

643854

FBRL
rRNA 2'-O-methyltransferase fibrillarin

5

9

High-throughput

0.714

High

1085660

TBL3
Transducin beta-like protein 3

1

16

High-throughput

0.691

High

1144713

WDR36
WD repeat-containing protein 36

1

20

High-throughput

0.691

High

1144753

WDR3
WD repeat-containing protein 3

1

19

High-throughput

0.691

High

1113158

CUL3
Cullin-3

3

20

Small-scale

0.656

High

904743

MECP2
Methyl-CpG-binding protein 2

2

5

High-throughput

0.628

High

1144729

DNJC7
DnaJ homolog subfamily C member 7

2

17

High-throughput

0.628

High

1144731

ZN692
Zinc finger protein 692

2

4

High-throughput

0.628

High

1144732

RBM4
RNA-binding protein 4

2

11

High-throughput

0.628

High

964620

DCAF7
DDB1- and CUL4-associated factor 7

1

18

High-throughput

0.621

High

657241

KALM
Anosmin-1

1

2

High-throughput

0.618

High

285295

EED
Polycomb protein EED

1

19

High-throughput

0.618

High

1088357

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

12

High-throughput

0.618

High

1132707

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

12

High-throughput

0.618

High

1144745

DCA13
DDB1- and CUL4-associated factor 13

1

18

Small-scale

0.618

High

1144692

IF16
Gamma-interferon-inducible protein 16

2

7

High-throughput

0.611

High

96685

E9PAV9
G patch domain-containing protein 4

2

5

High-throughput

0.584

High

259983

BRD4
Bromodomain-containing protein 4

2

20

High-throughput

0.584

High

345854

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

10

High-throughput

0.584

High

372082

MYC
Myc proto-oncogene protein

2

15

High-throughput

0.584

High

978952

RS6
Small ribosomal subunit protein eS6

2

5

High-throughput

0.584

High

1144750

DDX41
Probable ATP-dependent RNA helicase DDX41

1

5

High-throughput

0.575

High

438080

GLPB
Glycophorin-B

2

1

High-throughput

0.574

High

546974

FGF3
Fibroblast growth factor 3

2

2

High-throughput

0.574

High

935402

FGF8
Fibroblast growth factor 8

2

2

High-throughput

0.574

High

1144737

PACC1
Proton-activated chloride channel

2

3

High-throughput

0.574

High

396155

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

157404

CTRO
Citron Rho-interacting kinase

1

8

High-throughput

0.553

High

970539

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

13

High-throughput

0.553

High

1144698

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.553

High

1144736

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.553

High

290568

SURF6
Surfeit locus protein 6

1

4

High-throughput

0.536

High

388202

GLPA
Glycophorin-A

1

1

High-throughput

0.536

High

596114

H12
Histone H1.2

1

6

High-throughput

0.536

High

658195

RS3
Small ribosomal subunit protein uS3

1

7

High-throughput

0.536

High

785185

RL4
Large ribosomal subunit protein uL4

1

7

High-throughput

0.536

High

824159

RL13A
Large ribosomal subunit protein uL13

1

4

High-throughput

0.536

High

856702

BAG6
Large proline-rich protein BAG6

1

7

High-throughput

0.536

High

908403

HDGF
Hepatoma-derived growth factor

1

4

High-throughput

0.536

High

960738

RL15
Large ribosomal subunit protein eL15

1

3

High-throughput

0.536

High

1112494

CUL1
Cullin-1

1

20

High-throughput

0.536

High

1144704

WDR75
WD repeat-containing protein 75

1

19

High-throughput

0.536

High

1144728

MPH6
M-phase phosphoprotein 6

1

2

High-throughput

0.536

High

1144740

EXOS4
Exosome complex component RRP41

1

18

High-throughput

0.536

High

1144741

EXOS5
Exosome complex component RRP46

1

18

High-throughput

0.536

High

1144756

RL36
Large ribosomal subunit protein eL36

1

3

High-throughput

0.536

High

1144705

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

191650

MAGB2
Melanoma-associated antigen B2

1

5

High-throughput

0.489

High

1144702

ZN467
Zinc finger protein 467

1

1

High-throughput

0.489

High

1144706

UN45B
Protein unc-45 homolog B

1

14

High-throughput

0.489

High

1144725

TECTB
Beta-tectorin

1

3

High-throughput

0.489

High

1144755

KLH20
Kelch-like protein 20

1

4

High-throughput

0.489

High

529837

TAU
Microtubule-associated protein tau

1

14

High-throughput

0.481

High

129103

MEN1
Menin

1

5

High-throughput

0.479

High

172838

XPO1
Exportin-1

1

14

High-throughput

0.479

High

190918

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

3

High-throughput

0.479

High

223062

PRC1
Protein regulator of cytokinesis 1

1

6

High-throughput

0.479

High

274589

DNJB6
DnaJ homolog subfamily B member 6

1

10

High-throughput

0.479

High

330987

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

404067

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

413876

P53
Cellular tumor antigen p53

1

7

High-throughput

0.479

High

447047

NPM
Nucleophosmin

1

7

High-throughput

0.479

High

588754

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

695520

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

731320

STIP1
Stress-induced-phosphoprotein 1

1

15

High-throughput

0.479

High

768252

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

879114

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

13

High-throughput

0.479

High

937757

FOXA1
Hepatocyte nuclear factor 3-alpha

1

11

High-throughput

0.479

High

982678

RS24
Small ribosomal subunit protein eS24

1

3

High-throughput

0.479

High

1004596

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.479

High

1035635

KIF23
Kinesin-like protein KIF23

1

19

High-throughput

0.479

High

1087395

GRSF1
G-rich sequence factor 1

1

13

High-throughput

0.479

High

1096010

TADBP
TAR DNA-binding protein 43

1

13

High-throughput

0.479

High

1106896

BIRC3
Baculoviral IAP repeat-containing protein 3

1

7

High-throughput

0.479

High

1144693

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

1

High-throughput

0.479

High

1144697

ZN746
Zinc finger protein 746

1

5

High-throughput

0.479

High

1144703

ZCH18
Zinc finger CCCH domain-containing protein 18

1

11

High-throughput

0.479

High

1144708

SMC5
Structural maintenance of chromosomes protein 5

1

5

High-throughput

0.479

High

1144710

SIR6
NAD-dependent protein deacylase sirtuin-6

1

7

High-throughput

0.479

High

1144711

ZBT38
Zinc finger and BTB domain-containing protein 38

1

2

Small-scale

0.479

High

1144714

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

5

High-throughput

0.479

High

1144715

DNJC9
DnaJ homolog subfamily C member 9

1

15

High-throughput

0.479

High

1144716

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1144717

FBX32
F-box only protein 32

1

1

High-throughput

0.479

High

1144719

CHCH1
Small ribosomal subunit protein mS37

1

2

High-throughput

0.479

High

1144720

DCPS
m7GpppX diphosphatase

1

1

High-throughput

0.479

High

1144726

MMS19
MMS19 nucleotide excision repair protein homolog

1

1

High-throughput

0.479

High

1144727

RING2
E3 ubiquitin-protein ligase RING2

1

20

High-throughput

0.479

High

1144734

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

2

High-throughput

0.479

High

1144738

ECT2
Protein ECT2

1

11

High-throughput

0.479

High

1144739

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

6

High-throughput

0.479

High

1144744

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

7

High-throughput

0.479

High

1144746

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

7

High-throughput

0.479

High

1144747

TLS1
Splicing factor C9orf78

1

3

High-throughput

0.479

High

1144752

FZR1
Fizzy-related protein homolog

1

18

High-throughput

0.479

High

1144754

SMC3
Structural maintenance of chromosomes protein 3

1

1

High-throughput

0.479

High

1144700

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.458

High

1144709

STAG2
Cohesin subunit SA-2

1

0

High-throughput

0.458

High

1144724

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.458

High

429927

JUN
Transcription factor Jun

1

13

High-throughput

0.445

High

1130262

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

5

High-throughput

0.445

High

1144696

GPTC4
G patch domain-containing protein 4

1

5

High-throughput

0.445

High

1144712

RN169
E3 ubiquitin-protein ligase RNF169

1

3

Small-scale

0.445

High

563797

CFTR
Cystic fibrosis transmembrane conductance regulator

1

5

High-throughput

0.439

High

66888

SPDE4
Speedy protein E4

1

1

High-throughput

0.437

High

132051

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

4

High-throughput

0.437

High

272201

OBSL1
Obscurin-like protein 1

1

7

High-throughput

0.437

High

319783

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.437

High

504900

H2AB2
Histone H2A-Bbd type 2/3

1

6

High-throughput

0.437

High

1034159

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

12

High-throughput

0.437

High

1134896

CUL7
Cullin-7

1

3

High-throughput

0.437

High

1140304

KIF14
Kinesin-like protein KIF14

1

13

High-throughput

0.437

High

1141130

BRD3
Bromodomain-containing protein 3

1

20

High-throughput

0.437

High

1144701

CNTRL
Centriolin

1

14

High-throughput

0.437

High

1144721

CHM4C
Charged multivesicular body protein 4c

1

8

High-throughput

0.437

High

1144723

DDRGK
DDRGK domain-containing protein 1

1

5

High-throughput

0.437

High

1144733

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.437

High

1144735

CHM4B
Charged multivesicular body protein 4b

1

8

High-throughput

0.437

High

1144749

HECW2
E3 ubiquitin-protein ligase HECW2

1

6

High-throughput

0.437

High

1144751

HECD1
E3 ubiquitin-protein ligase HECTD1

1

12

High-throughput

0.437

High

69944

A8KAG1
G patch domain-containing protein 4

1

5

High-throughput

0.407

High

1144695

KLH22
Kelch-like protein 22

1

6

High-throughput

0.407

High

1144707

BBS7
BBSome complex member BBS7

2

0

High-throughput

0.328

High

1144743

ZNF71
Endothelial zinc finger protein induced by tumor necrosis factor alpha

2

0

High-throughput

0.328

High

290248

TM1L1
TOM1-like protein 1

1

0

High-throughput

0.282

High

376606

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

0

High-throughput

0.279

Low

1127386

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.279

Low

1144694

ANO4
Anoctamin-4

1

0

High-throughput

0.279

Low

1144699

ENOF1
Mitochondrial enolase superfamily member 1

1

0

High-throughput

0.279

Low

1144722

DTBP1
Dysbindin

1

0

High-throughput

0.279

Low

1126084

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

1144718

TM230
Transmembrane protein 230

1

0

High-throughput

0.249

Low

1144730

B9D2
B9 domain-containing protein 2

1

0

High-throughput

0.249

Low

635866

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025