HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: CALX (P27824)
Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90)
Gene: CANX

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35384245, 36736316
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005509 - calcium ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1114 Hs			1 592
+	Hs
		161002 RET_HUMAN (1-1114): 0: 1295: 100.00		CLGN_HUMAN (11-546): 0: 652: 59.85
+	Hs
		601462 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		507869 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		337977 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		383628 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		384315 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		607885 FGFR4_HUMAN (535-1054): 4.33e-124: 401: 37.89		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		654370 NTRK3_HUMAN (638-1020): 2.11e-106: 355: 31.19		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		161008 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		CLGN_HUMAN (11-546): 0: 652: 59.85
+	Hs
		160994 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		CLGN_HUMAN (11-546): 0: 652: 59.85
+	Hs
		160995 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		CLGN_HUMAN (11-546): 0: 652: 59.85
+	Hs
		654121 VGFR3_HUMAN (677-1012): 1.84e-76: 278: 41.25		CALX_HUMAN (1-592): 0: 786: 100.00
+	At
		83441 Y1755_ARATH (249-1039): 2.56e-178: 546: 14.35		CALX2_ARATH (68-554): 4.23e-159: 467: 40.91
+	Hs
		161071 NTRK3_HUMAN (638-1020): 2.11e-106: 355: 31.19		CLGN_HUMAN (11-546): 0: 652: 59.85
+	At
		248528 SIRK_ARATH (246-1009): 1.27e-151: 476: 12.23		CALX2_ARATH (68-554): 4.23e-159: 467: 40.91
+	Hs
		161030 VGFR3_HUMAN (677-1012): 1.84e-76: 278: 41.25		CLGN_HUMAN (11-546): 0: 652: 59.85
+	Hs
		161031 FLT3_HUMAN (714-1014): 2.21e-72: 262: 40.00		CLGN_HUMAN (11-546): 0: 652: 59.85
+	Hs
		337975 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		CALR_HUMAN (67-470): 1.19e-141: 418: 38.33
+	Hs
		384313 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		CALR_HUMAN (67-470): 1.19e-141: 418: 38.33
+	Hs
		653500 VGFR3_HUMAN (677-1012): 1.84e-76: 278: 41.25		CALR_HUMAN (67-470): 1.19e-141: 418: 38.33