HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: MERL (P35240)
Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)
Gene: NF2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	32062451
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FERM_M~PK_Tyr_Ser-Thr
Common GO terms	GO:0000165 - MAPK cascade GO:0005769 - early endosome GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1114 Hs			1 595
+	Hs
		434145 RET_HUMAN (1-1114): 0: 1295: 100.00		RADI_HUMAN (19-595): 5.41e-151: 448: 45.47
+	Hs
		507884 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		MERL_HUMAN (1-595): 1.12e-172: 504: 100.00
+	Hs
		338026 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		MERL_HUMAN (1-595): 1.12e-172: 504: 100.00
+	Hs
		383650 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		MERL_HUMAN (1-595): 1.12e-172: 504: 100.00
+	Hs
		507828 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20
+	Hs
		507885 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		RADI_HUMAN (19-595): 5.41e-151: 448: 45.47
+	Hs
		609192 FGFR3_HUMAN (501-1061): 4.63e-147: 462: 33.16		RADI_HUMAN (19-595): 5.41e-151: 448: 45.47
+	Hs
		337871 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20
+	Hs
		383579 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20
+	Hs
		507865 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		MOES_HUMAN (19-595): 5.97e-146: 435: 44.44
+	Hs
		338027 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		RADI_HUMAN (19-595): 5.41e-151: 448: 45.47
+	Hs
		383651 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		RADI_HUMAN (19-595): 5.41e-151: 448: 45.47
+	Hs
		383621 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		MOES_HUMAN (19-595): 5.97e-146: 435: 44.44
+	Hs
		505551 FGFR3_HUMAN (501-1061): 4.63e-147: 462: 33.16		EPB41_HUMAN (3-566): 9.71e-126: 392: 19.73
+	Hs
		508209 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		E41LA_HUMAN (19-416): 3.96e-121: 375: 24.46
+	Hs
		508287 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		FARP1_HUMAN (2-526): 5.38e-114: 366: 18.35
+	Hs
		338978 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		E41L1_HUMAN (1-535): 3.42e-120: 378: 21.61
+	Hs
		299238 FGFR3_HUMAN (501-1061): 4.63e-147: 462: 33.16		FARP2_HUMAN (3-537): 6.42e-112: 360: 17.89
+	Hs
		383622 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		PTN3_HUMAN (3-433): 3.81e-115: 366: 22.52
+	Hs
		204585 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		E41L2_HUMAN (11-519): 9e-113: 361: 19.70