Protein: P53
Cellular tumor antigen p53 (Tumor suppressor p53)

Gene: P53, Tp53
Organism: Mus musculus
Interactions: 102
UniProt ID: P02340

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000423 - mitophagy
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

356823

MDM2
E3 ubiquitin-protein ligase Mdm2

32

10

Small-scale

0.993

High

70883

EP300
Histone acetyltransferase p300

6

18

Small-scale

0.937

High

356818

P53
Cellular tumor antigen p53

6

14

Small-scale

0.923

High

193155

MDM4
Protein Mdm4

5

10

Small-scale

0.919

High

356868

B2CL1
Bcl-2-like protein 1

3

9

Small-scale

0.847

High

101415

F8VPR5
histone acetyltransferase

2

16

Small-scale

0.757

High

292426

P63
Tumor protein 63

2

14

Small-scale

0.757

High

356889

P73
Tumor protein p73

2

14

Small-scale

0.757

High

250857

BARD1
BRCA1-associated RING domain protein 1

2

15

Small-scale

0.754

High

356859

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

5

Small-scale

0.683

High

356879

MK08
Mitogen-activated protein kinase 8

4

12

Small-scale

0.676

High

356841

TP53B
TP53-binding protein 1

1

11

Small-scale

0.646

High

356901

S4R1Y1
Cullin 9

3

11

Small-scale

0.640

High

356855

SKIL
Ski-like protein

2

2

Small-scale

0.624

High

356867

ARF
Tumor suppressor ARF

3

0

Small-scale

0.622

High

356898

IKBA
NF-kappa-B inhibitor alpha

1

9

High-throughput

0.621

High

93499

ANR11
Ankyrin repeat domain-containing protein 11

1

17

Small-scale

0.618

High

356820

BCL2
Apoptosis regulator Bcl-2

1

9

Small-scale

0.618

High

356829

CBP
Histone lysine acetyltransferase CREBBP

1

16

Small-scale

0.618

High

356847

BAX
Apoptosis regulator BAX

1

9

Small-scale

0.618

High

356872

DAPK1
Death-associated protein kinase 1

1

7

Small-scale

0.618

High

356900

PSD10
26S proteasome non-ATPase regulatory subunit 10

1

8

Small-scale

0.618

High

193120

DAXX
Death domain-associated protein 6

2

4

Small-scale

0.611

High

139294

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

2

4

Small-scale

0.584

High

193170

AXIN1
Axin-1

2

1

Small-scale

0.584

High

356878

WWOX
WW domain-containing oxidoreductase

2

5

Small-scale

0.584

High

356893

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

2

3

Small-scale

0.584

High

356896

GSK3B
Glycogen synthase kinase-3 beta

2

6

Small-scale

0.584

High

103319

G3X9P9
SUMO/sentrin specific peptidase 2-like 2A

1

6

Small-scale

0.578

High

356861

MELK
Maternal embryonic leucine zipper kinase

1

2

Small-scale

0.578

High

356824

PAX3
Paired box protein Pax-3

1

4

Small-scale

0.561

High

356862

DMC1
Meiotic recombination protein DMC1/LIM15 homolog

1

3

Small-scale

0.561

High

356880

BRNP1
BMP/retinoic acid-inducible neural-specific protein 1

1

1

Small-scale

0.561

High

356899

ZN292
Zinc finger protein 292

1

5

High-throughput

0.541

High

356849

KCMA1
Calcium-activated potassium channel subunit alpha-1

1

0

Small-scale

0.537

High

356838

HMGB1
High mobility group protein B1

1

9

Small-scale

0.536

High

356842

BACH1
Transcription regulator protein BACH1

1

11

Small-scale

0.536

High

356865

TIF1A
Transcription intermediary factor 1-alpha

1

18

Small-scale

0.536

High

356826

TWST1
Twist-related protein 1

1

3

Small-scale

0.515

High

356830

MK14
Mitogen-activated protein kinase 14

1

13

Small-scale

0.515

High

356837

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

3

High-throughput

0.515

High

222927

MAPK5
MAP kinase-activated protein kinase 5

1

4

Small-scale

0.501

High

356844

CDK2
Cyclin-dependent kinase 2

1

6

Small-scale

0.501

High

356864

ATM
Serine-protein kinase ATM

1

8

Small-scale

0.501

High

356886

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

3

Small-scale

0.501

High

140213

HDAC1
Histone deacetylase 1

1

7

Small-scale

0.500

High

356857

NCOR1
Nuclear receptor corepressor 1

1

5

Small-scale

0.500

High

356860

MAFK
Transcription factor MafK

1

1

Small-scale

0.500

High

292440

PIAS1
E3 SUMO-protein ligase PIAS1

1

10

Small-scale

0.481

High

356845

SMYD1
Histone-lysine N-methyltransferase Smyd1

1

2

Small-scale

0.481

High

356854

SIN3A
Paired amphipathic helix protein Sin3a

1

2

High-throughput

0.481

High

356870

MED16
Mediator of RNA polymerase II transcription subunit 16

1

4

High-throughput

0.481

High

356874

PIAS2
E3 SUMO-protein ligase PIAS2

1

10

Small-scale

0.481

High

356890

PIAS4
E3 SUMO-protein ligase PIAS4

1

10

Small-scale

0.481

High

250864

1433S
14-3-3 protein sigma

1

7

Small-scale

0.479

High

292640

SP1
Transcription factor Sp1

1

7

Small-scale

0.479

High

356821

HS71L
Heat shock 70 kDa protein 1-like

1

6

Small-scale

0.479

High

356822

HS71B
Heat shock 70 kDa protein 1B

1

6

Small-scale

0.479

High

356825

NECD
Necdin

1

8

Small-scale

0.479

High

356827

IRS1
Insulin receptor substrate 1

1

6

Small-scale

0.479

High

356828

CDN1A
Cyclin-dependent kinase inhibitor 1

1

4

Small-scale

0.479

High

356831

CCNG1
Cyclin-G1

1

9

Small-scale

0.479

High

356833

RUVB1
RuvB-like 1

1

2

Small-scale

0.479

High

356834

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

6

Small-scale

0.479

High

356835

RS26
Small ribosomal subunit protein eS26

1

1

Small-scale

0.479

High

356836

YBOX1
Y-box-binding protein 1

1

2

Small-scale

0.479

High

356839

GFI1
Zinc finger protein Gfi-1

1

7

Small-scale

0.479

High

356840

ELAV1
ELAV-like protein 1

1

4

Small-scale

0.479

High

356843

PRKDC
DNA-dependent protein kinase catalytic subunit

1

8

Small-scale

0.479

High

356846

TF65
Transcription factor p65

1

8

Small-scale

0.479

High

356848

RAD51
DNA repair protein RAD51 homolog 1

1

3

Small-scale

0.479

High

356850

SMCA4
Transcription activator BRG1

1

9

Small-scale

0.479

High

356851

DDB1
DNA damage-binding protein 1

1

3

Small-scale

0.479

High

356852

KMT2E
Inactive histone-lysine N-methyltransferase 2E

1

10

Small-scale

0.479

High

356853

HERC2
E3 ubiquitin-protein ligase HERC2

1

18

Small-scale

0.479

High

356856

KLF4
Krueppel-like factor 4

1

10

Small-scale

0.479

High

356858

Q60979
SnoN protein

1

2

Small-scale

0.479

High

356863

NPM
Nucleophosmin

1

1

Small-scale

0.479

High

356866

SQSTM
Sequestosome-1

1

3

Small-scale

0.479

High

356869

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

6

Small-scale

0.479

High

356871

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

14

Small-scale

0.479

High

356873

TOPRS
E3 ubiquitin-protein ligase Topors

1

5

Small-scale

0.479

High

356875

EP400
E1A-binding protein p400

1

10

Small-scale

0.479

High

356876

ZBT7C
Zinc finger and BTB domain-containing protein 7C

1

12

Small-scale

0.479

High

356877

CUL7
Cullin-7

1

6

Small-scale

0.479

High

356881

REV1
DNA repair protein REV1

1

3

Small-scale

0.479

High

356882

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

5

Small-scale

0.479

High

356883

FOXP3
Forkhead box protein P3

1

11

High-throughput

0.479

High

356884

PPIF
Peptidyl-prolyl cis-trans isomerase F, mitochondrial

1

4

Small-scale

0.479

High

356885

PARK7
Parkinson disease protein 7 homolog

1

1

Small-scale

0.479

High

356887

RL11
Large ribosomal subunit protein uL5

1

2

Small-scale

0.479

High

356888

RN128
E3 ubiquitin-protein ligase RNF128

1

6

Small-scale

0.479

High

356892

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

1

Small-scale

0.479

High

356894

FAK2
Protein-tyrosine kinase 2-beta

1

9

Small-scale

0.479

High

356895

HIPK2
Homeodomain-interacting protein kinase 2

1

16

Small-scale

0.479

High

356897

PRKN
E3 ubiquitin-protein ligase parkin

1

10

Small-scale

0.479

High

356819

SODM
Superoxide dismutase [Mn], mitochondrial

1

0

Small-scale

0.458

High

356832

DPOG1
DNA polymerase subunit gamma-1

1

0

Small-scale

0.458

High

356891

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

Small-scale

0.458

High

102303

G3UW74
Mediator of RNA polymerase II transcription subunit 16

1

4

High-throughput

0.457

High

56926

PRD16
Histone-lysine N-methyltransferase PRDM16

1

6

Small-scale

0.445

High


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Last updated: 15 Jul 2024