Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET
Interactor 2: GFRA1 (P56159)
GDNF family receptor alpha-1 (GDNF receptor alpha-1) (GDNFR-alpha-1) (GFR-alpha-1) (RET ligand 1) (TGF-beta-related neurotrophic factor receptor 1)
Gene: GFRA1
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.70 | 1.00 | 0.840 |
The method score is based on:
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Cadherin~GDNF, GDNF~RET_CLD1, GDNF~RET_CLD3 |
| Common GO terms | GO:0005886 - plasma membrane GO:0030424 - axon GO:0035860 - glial cell-derived neurotrophic factor receptor signaling pathway GO:0038023 - signaling receptor activity GO:0043025 - neuronal cell body and 2 others more... |
| Homologous interactions | 2 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
