HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: GRB10 (Q13322)
Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR)
Gene: GRB10

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.840

Property	Details
Experiments	7665556, 28794017
Identification Methods	two hybrid, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	BPS~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1114 Hs			1 594
+	Hs
		434194 RET_HUMAN (1-1114): 0: 1295: 100.00		GRB7_HUMAN (107-594): 1.36e-174: 507: 55.60
+	Hs
		434223 RET_HUMAN (1-1114): 0: 1295: 100.00		RAPH1_HUMAN (34-484): 6.16e-107: 350: 23.94
+	Hs
		434125 RET_HUMAN (1-1114): 0: 1295: 100.00		SRC_HUMAN (443-590): 9.55e-47: 174: 22.08
+	Mm
		403421 RET_MOUSE (1-1114): 0: 1275: 83.24		SRC_MOUSE (443-590): 1.24e-46: 173: 22.08
+	Hs
		434170 RET_HUMAN (1-1114): 0: 1295: 100.00		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		507999 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		GRB14_HUMAN (76-594): 0: 575: 55.08
+	Hs
		507829 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		VAV_HUMAN (36-594): 3.93e-139: 426: 14.11
+	Hs
		508074 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		RAPH1_HUMAN (34-484): 6.16e-107: 350: 23.94
+	Hs
		507964 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		ITK_HUMAN (293-589): 1.9e-60: 213: 15.47
+	Hs
		145979 ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43		SH2B2_HUMAN (301-581): 7.5e-55: 198: 16.29
+	Hs
		412008 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		FYN_HUMAN (441-591): 5.64e-47: 174: 20.38
+	Hs
		522773 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		SRC_HUMAN (443-590): 9.55e-47: 174: 22.08
+	Hs
		433573 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		LYN_HUMAN (409-593): 7.45e-46: 171: 17.19
+	Hs
		411729 ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43		LCK_HUMAN (420-589): 7.66e-49: 179: 19.66
+	Hs
		433229 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		YES_HUMAN (441-592): 9.17e-47: 174: 20.89
+	Hs
		507818 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		SRC_HUMAN (443-590): 9.55e-47: 174: 22.08
+	Hs
		412202 ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43		FYN_HUMAN (441-591): 5.64e-47: 174: 20.38
+	Hs
		601492 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		507939 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Rn
		728442 NTRK1_RAT (376-1018): 1.45e-149: 468: 24.47		GRB2_RAT (489-575): 3.64e-20: 91.4: 29.89