HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: GRB7 (Q14451)
Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein)
Gene: GRB7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	8631863
Identification Methods	pull down, far western blotting
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	BPS~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0030335 - positive regulation of cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1114 Hs			1 532
+	Hs
		434186 RET_HUMAN (1-1114): 0: 1295: 100.00		GRB10_HUMAN (1-532): 0: 593: 53.17
+	Hs
		434223 RET_HUMAN (1-1114): 0: 1295: 100.00		RAPH1_HUMAN (100-352): 7.05e-87: 293: 30.83
+	Hs
		434135 RET_HUMAN (1-1114): 0: 1295: 100.00		PLCG1_HUMAN (200-532): 6.64e-50: 187: 14.69
+	Hs
		434125 RET_HUMAN (1-1114): 0: 1295: 100.00		SRC_HUMAN (351-528): 1.08e-46: 172: 24.32
+	Mm
		403421 RET_MOUSE (1-1114): 0: 1275: 83.24		SRC_MOUSE (351-528): 1.55e-46: 172: 24.32
+	Hs
		434170 RET_HUMAN (1-1114): 0: 1295: 100.00		GRB2_HUMAN (427-513): 2.66e-13: 71: 29.89
+	Hs
		507999 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		GRB14_HUMAN (12-532): 0: 614: 47.91
+	Hs
		508074 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		RAPH1_HUMAN (100-352): 7.05e-87: 293: 30.83
+	Hs
		507829 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		VAV_HUMAN (84-526): 4.42e-86: 285: 15.27
+	Hs
		580923 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		PLCG1_HUMAN (200-532): 6.64e-50: 187: 14.69
+	Hs
		507964 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		ITK_HUMAN (232-527): 1.19e-54: 196: 18.10
+	Hs
		412008 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		FYN_HUMAN (357-529): 5.57e-50: 182: 20.88
+	Hs
		433573 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		LYN_HUMAN (347-531): 4.7e-49: 178: 18.46
+	Mm
		729415 VGFR2_MOUSE (344-1105): 1.6e-146: 475: 23.94		PLCG1_MOUSE (200-532): 1.92e-49: 185: 14.97
+	Hs
		507843 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		PLCG1_HUMAN (200-532): 6.64e-50: 187: 14.69
+	Hs
		522773 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		SRC_HUMAN (351-528): 1.08e-46: 172: 24.32
+	Hs
		433229 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		YES_HUMAN (366-528): 8.94e-48: 175: 19.53
+	Hs
		507818 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		SRC_HUMAN (351-528): 1.08e-46: 172: 24.32
+	Hs
		601492 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		GRB2_HUMAN (427-513): 2.66e-13: 71: 29.89
+	Hs
		507939 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		GRB2_HUMAN (427-513): 2.66e-13: 71: 29.89