HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: PEAK1 (Q9H792)
Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269)
Gene: PEAK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	32062451
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Pkinase
Common GO terms	-
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1114 Hs			1 1746
+	Hs
		508196 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		338986 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		385530 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		1083894 NTRK2_HUMAN (590-1018): 1.26e-124: 403: 30.74		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		608132 FGFR4_HUMAN (535-1054): 4.33e-124: 401: 37.89		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		507876 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Hs
		338299 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		KPCE_HUMAN (1354-1719): 3.19e-92: 318: 13.98
+	Hs
		507838 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		338004 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Hs
		383640 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Hs
		337895 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		607895 FGFR4_HUMAN (535-1054): 4.33e-124: 401: 37.89		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Hs
		508055 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		OBSCN_HUMAN (933-1713): 2.16e-56: 220: 11.37
+	Hs
		338596 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		PEAK3_HUMAN (1653-1743): 1.22e-30: 129: 38.46