HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: SGT1 (Q9Y2Z0)
Protein SGT1 homolog (Protein 40-6-3) (Sgt1) (Suppressor of G2 allele of SKP1 homolog)
Gene: SUGT1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1114 Hs			1 365
+	Hs
		434258 RET_HUMAN (1-1114): 0: 1295: 100.00		SGTB_HUMAN (91-296): 3.48e-10: 62.2: 12.14
+	Hs
		609621 FGFR3_HUMAN (501-1061): 4.63e-147: 462: 33.16		SGT1_HUMAN (1-365): 2.37e-88: 272: 100.00
+	Hs
		385766 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		SGT1_HUMAN (1-365): 2.37e-88: 272: 100.00
+	Dm
		1181878 Q7KT06_DROME (194-1114): 3.46e-167: 528: 29.59		Q9VH81_DROME (4-218): 1.63e-39: 148: 13.58
+	Hs
		608205 FGFR4_HUMAN (535-1054): 4.33e-124: 401: 37.89		SGT1_HUMAN (1-365): 2.37e-88: 272: 100.00
+	Hs
		73111 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		B4DYC6_HUMAN (57-365): 4.31e-64: 207: 86.41
+	Hs
		338906 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		Q9BPW0_HUMAN (9-242): 3.32e-39: 147: 14.71
+	Hs
		383952 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		Q9BPW0_HUMAN (9-242): 3.32e-39: 147: 14.71
+	Hs
		338171 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		PPP5_HUMAN (9-242): 1.39e-38: 145: 14.71
+	Hs
		384545 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		PPP5_HUMAN (9-242): 1.39e-38: 145: 14.71
+	Hs
		507978 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		DNJC3_HUMAN (6-326): 2.67e-25: 108: 15.69
+	Hs
		338364 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		DNJC3_HUMAN (6-326): 2.67e-25: 108: 15.69
+	Hs
		385527 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		RPAP3_HUMAN (3-129): 5.92e-27: 114: 14.17
+	Hs
		729389 VGFR3_HUMAN (677-1012): 1.84e-76: 278: 41.25		SGT1_HUMAN (1-365): 2.37e-88: 272: 100.00
+	Hs
		174540 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		OGT1_HUMAN (48-303): 5e-18: 87.6: 9.51
+	Hs
		385317 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		TTC28_HUMAN (7-112): 2.84e-13: 73.3: 26.36
+	Hs
		297018 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		TOM70_HUMAN (3-221): 1.5e-09: 61.4: 9.29
+	Hs
		297020 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		TOM70_HUMAN (3-221): 1.5e-09: 61.4: 9.29
+	Hs
		1028052 NTRK3_HUMAN (638-1020): 2.11e-106: 355: 31.19		DNJC3_HUMAN (6-326): 2.67e-25: 108: 15.69