HitPredict

Interactor 1: TPM2 (P07951)
Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2)
Gene: TPM2

Interactor 2: PDLI7 (Q9NR12)
PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma)
Gene: PDLIM7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.639

Property	Details
Experiments	26496610, 10359609
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005829 - cytosol GO:0015629 - actin cytoskeleton
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 284 Hs			1 457
+	Hs
		451318 TPM1_HUMAN (1-284): 4.27e-46: 158: 85.56		PDLI7_HUMAN (1-457): 2.02e-91: 286: 100.00
+	Hs
		419055 TPM3_HUMAN (1-284): 1.59e-44: 154: 86.27		PDLI7_HUMAN (1-457): 2.02e-91: 286: 100.00
+	Hs
		110806 H7BYY1_HUMAN (1-241): 2.86e-15: 75.3: 21.58		PDLI7_HUMAN (1-457): 2.02e-91: 286: 100.00
+	Hs
		932058 TPM4_HUMAN (1-240): 6.77e-14: 71.4: 21.67		PDLI7_HUMAN (1-457): 2.02e-91: 286: 100.00
+	Mm
		886037 TPM1_MOUSE (1-284): 3.6e-46: 158: 85.92		PDLI5_MOUSE (1-282): 2.11e-28: 120: 24.47
+	Mm
		886046 TPM2_MOUSE (1-284): 3.99e-41: 145: 99.65		PDLI5_MOUSE (1-282): 2.11e-28: 120: 24.47
+	Hs
		434422 TPM2_HUMAN (1-284): 2.69e-41: 145: 100.00		PDLI5_HUMAN (1-282): 6.17e-28: 118: 24.82
+	Hs
		434336 TPM2_HUMAN (1-284): 2.69e-41: 145: 100.00		ZN250_HUMAN (362-457): 4.28e-23: 103: 6.25
+	Hs
		418964 TPM3_HUMAN (1-284): 1.59e-44: 154: 86.27		TRIP6_HUMAN (396-457): 6.89e-09: 59.7: 27.42
+	Hs
		1076422 Q5VU62_HUMAN (127-284): 2.42e-44: 149: 86.71		TRIP6_HUMAN (396-457): 6.89e-09: 59.7: 27.42
+	Hs
		932007 TPM4_HUMAN (1-240): 6.77e-14: 71.4: 21.67		TRIP6_HUMAN (396-457): 6.89e-09: 59.7: 27.42