Protein: DHX36
ATP-dependent DNA/RNA helicase DHX36 (EC 3.6.4.12) (EC 3.6.4.13) (DEAD/H box polypeptide 36) (DEAH-box protein 36) (G4-resolvase-1) (G4R1) (MLE-like protein 1) (RNA helicase associated with AU-rich element protein)

Gene: DHX36
Organism: Homo sapiens
Interactions: 232
UniProt ID: Q9H2U1

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0000781 - chromosome, telomeric region
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001503 - ossification

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

346319

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

20

High-throughput

0.754

High

1027748

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

10

High-throughput

0.691

High

1062643

DHX9
ATP-dependent RNA helicase A

1

16

High-throughput

0.691

High

1168889

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

10

High-throughput

0.691

High

1340456

DDX55
ATP-dependent RNA helicase DDX55

1

20

High-throughput

0.691

High

1429458

PAIP1
Polyadenylate-binding protein-interacting protein 1

1

4

High-throughput

0.691

High

590491

GATA1
Erythroid transcription factor

3

1

High-throughput

0.667

High

1118990

BYST
Bystin

3

2

High-throughput

0.667

High

1332714

ZBT38
Zinc finger and BTB domain-containing protein 38

3

5

High-throughput

0.667

High

1104483

ILK
Scaffold protein ILK

1

3

High-throughput

0.665

High

1432158

LN28A
Protein lin-28 homolog A

3

18

High-throughput

0.650

High

373128

MYC
Myc proto-oncogene protein

3

15

High-throughput

0.640

High

485412

ROA1
Heterogeneous nuclear ribonucleoprotein A1

3

14

High-throughput

0.633

High

546998

FGF3
Fibroblast growth factor 3

2

12

High-throughput

0.628

High

935450

FGF8
Fibroblast growth factor 8

2

12

High-throughput

0.628

High

141658

DDX3X
ATP-dependent RNA helicase DDX3X

1

13

High-throughput

0.618

High

302953

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

14

High-throughput

0.618

High

316005

RECQ4
ATP-dependent DNA helicase Q4

1

20

High-throughput

0.618

High

345112

RIGI
Antiviral innate immune response receptor RIG-I

1

20

Small-scale

0.618

High

1042925

ERCC6
DNA excision repair protein ERCC-6

1

17

Small-scale

0.618

High

1255506

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.618

High

1323573

CMTR1
Cap-specific mRNA

1

3

High-throughput

0.618

High

1361074

ASB12
Ankyrin repeat and SOCS box protein 12

1

2

High-throughput

0.618

High

982820

RS24
Small ribosomal subunit protein eS24

2

2

High-throughput

0.611

High

1365668

LAR4B
La-related protein 4B

2

17

High-throughput

0.611

High

1432166

DISC1
Disrupted in schizophrenia 1 protein

2

3

High-throughput

0.606

High

658402

RS3
Small ribosomal subunit protein uS3

2

6

High-throughput

0.601

High

809842

RS19
Small ribosomal subunit protein eS19

2

8

High-throughput

0.601

High

860942

RS10
Small ribosomal subunit protein eS10

2

7

High-throughput

0.601

High

1009317

PRR3
Proline-rich protein 3

2

3

High-throughput

0.601

High

1016609

SRSF3
Serine/arginine-rich splicing factor 3

2

20

High-throughput

0.601

High

1112172

KRR1
KRR1 small subunit processome component homolog

2

6

High-throughput

0.601

High

129418

MEN1
Menin

2

5

High-throughput

0.584

High

589663

RFA2
Replication protein A 32 kDa subunit

2

12

High-throughput

0.584

High

696481

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

9

High-throughput

0.584

High

766843

PHB1
Prohibitin 1

2

4

High-throughput

0.584

High

769152

RFA3
Replication protein A 14 kDa subunit

2

10

High-throughput

0.584

High

1432164

ANLN
Anillin

2

7

High-throughput

0.584

High

1102504

IFIT5
Interferon-induced protein with tetratricopeptide repeats 5

1

4

High-throughput

0.575

High

1246984

RICTR
Rapamycin-insensitive companion of mTOR

1

3

Small-scale

0.554

High

1432178

HECD1
E3 ubiquitin-protein ligase HECTD1

1

16

High-throughput

0.553

High

191797

MAGB2
Melanoma-associated antigen B2

1

8

High-throughput

0.536

High

250826

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

6

High-throughput

0.536

High

290726

SURF6
Surfeit locus protein 6

1

3

High-throughput

0.536

High

376426

PDGFB
Platelet-derived growth factor subunit B

1

1

High-throughput

0.536

High

419202

H2A1B
Histone H2A type 1-B/E

1

14

High-throughput

0.536

High

431246

LA
Lupus La protein

1

17

High-throughput

0.536

High

447432

NPM
Nucleophosmin

1

6

High-throughput

0.536

High

462637

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

20

High-throughput

0.536

High

476818

RSSA
Small ribosomal subunit protein uS2

1

12

High-throughput

0.536

High

502530

H2A1
Histone H2A type 1

1

14

High-throughput

0.536

High

521933

H14
Histone H1.4

1

20

High-throughput

0.536

High

586885

RS2
Small ribosomal subunit protein uS5

1

9

High-throughput

0.536

High

596351

H12
Histone H1.2

1

20

High-throughput

0.536

High

615979

RL17
Large ribosomal subunit protein uL22

1

6

High-throughput

0.536

High

686422

RL13
Large ribosomal subunit protein eL13

1

5

High-throughput

0.536

High

729452

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

20

High-throughput

0.536

High

854289

KI67
Proliferation marker protein Ki-67

1

5

High-throughput

0.536

High

859068

RL27A
Large ribosomal subunit protein uL15

1

3

High-throughput

0.536

High

859453

RL5
Large ribosomal subunit protein uL18

1

6

High-throughput

0.536

High

960886

RL15
Large ribosomal subunit protein eL15

1

4

High-throughput

0.536

High

970103

RS16
Small ribosomal subunit protein uS9

1

9

High-throughput

0.536

High

973303

RS13
Small ribosomal subunit protein uS15

1

4

High-throughput

0.536

High

978721

RL23A
Large ribosomal subunit protein uL23

1

6

High-throughput

0.536

High

979230

RS6
Small ribosomal subunit protein eS6

1

6

High-throughput

0.536

High

984976

RL31
Large ribosomal subunit protein eL31

1

7

High-throughput

0.536

High

1016224

RL19
Large ribosomal subunit protein eL19

1

6

High-throughput

0.536

High

1023286

RBM3
RNA-binding protein 3

1

18

High-throughput

0.536

High

1061142

SRSF1
Serine/arginine-rich splicing factor 1

1

20

High-throughput

0.536

High

1089550

ILF2
Interleukin enhancer-binding factor 2

1

8

High-throughput

0.536

High

1099247

SRSF5
Serine/arginine-rich splicing factor 5

1

20

High-throughput

0.536

High

1099529

SRSF6
Serine/arginine-rich splicing factor 6

1

20

High-throughput

0.536

High

1114277

CUL3
Cullin-3

1

20

High-throughput

0.536

High

1116009

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

7

High-throughput

0.536

High

1148789

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

15

High-throughput

0.536

High

1160078

SRSF7
Serine/arginine-rich splicing factor 7

1

20

High-throughput

0.536

High

1252516

LN28B
Protein lin-28 homolog B

1

18

High-throughput

0.536

High

1252675

ZN574
Zinc finger protein 574

1

3

High-throughput

0.536

High

1291205

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

8

High-throughput

0.536

High

1314836

ERF3B
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

1

12

High-throughput

0.536

High

1360476

PSPC1
Paraspeckle component 1

1

20

High-throughput

0.536

High

1370369

CSN5
COP9 signalosome complex subunit 5

1

12

High-throughput

0.536

High

1387889

PABP5
Polyadenylate-binding protein 5

1

11

High-throughput

0.536

High

1390610

NEIL1
Endonuclease 8-like 1

1

3

High-throughput

0.536

High

1395703

ZN668
Zinc finger protein 668

1

3

High-throughput

0.536

High

1409838

RBM4B
RNA-binding protein 4B

1

10

High-throughput

0.536

High

1413556

H2AJ
Histone H2A.J

1

14

High-throughput

0.536

High

1413978

MMTA2
Multiple myeloma tumor-associated protein 2

1

2

High-throughput

0.536

High

1432168

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

2

High-throughput

0.536

High

1432173

PURG
Purine-rich element-binding protein gamma

1

4

High-throughput

0.536

High

1432174

AGO2
Protein argonaute-2

1

12

High-throughput

0.536

High

1432175

AGO1
Protein argonaute-1

1

13

High-throughput

0.536

High

1432176

ZN346
Zinc finger protein 346

1

8

High-throughput

0.536

High

1432177

ZN777
Zinc finger protein 777

1

5

High-throughput

0.536

High

1432179

ABT1
Activator of basal transcription 1

1

5

High-throughput

0.536

High

1432181

RT17
Small ribosomal subunit protein uS17m

1

2

High-throughput

0.536

High

1432182

YBOX2
Y-box-binding protein 2

1

16

High-throughput

0.536

High

1432184

RBM19
Probable RNA-binding protein 19

1

18

High-throughput

0.536

High

1432171

DUX4
Double homeobox protein 4

1

3

High-throughput

0.516

High

891784

GSK3B
Glycogen synthase kinase-3 beta

1

12

High-throughput

0.515

High

1155759

EZH2
Histone-lysine N-methyltransferase EZH2

1

7

High-throughput

0.515

High

981697

RAN
GTP-binding nuclear protein Ran

1

4

High-throughput

0.515

High

192643

NUP42
Nucleoporin NUP42

1

0

High-throughput

0.513

High

1152243

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

1419535

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

10

High-throughput

0.500

High

317679

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.493

High

1419464

PANK2
Pantothenate kinase 2, mitochondrial

1

0

High-throughput

0.493

High

1432167

PARVA
Alpha-parvin

1

0

High-throughput

0.493

High

1432183

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.493

High

1127489

FGFP1
Fibroblast growth factor-binding protein 1

1

3

High-throughput

0.489

High

1201156

CCD93
Coiled-coil domain-containing protein 93

1

3

High-throughput

0.489

High

1278634

HEAT3
HEAT repeat-containing protein 3

1

2

High-throughput

0.489

High

157843

CTRO
Citron Rho-interacting kinase

1

12

High-throughput

0.479

High

170345

AURKA
Aurora kinase A

1

7

High-throughput

0.479

High

171925

ZN263
Zinc finger protein 263

1

2

Small-scale

0.479

High

194343

R113A
E3 ubiquitin-protein ligase RNF113A

1

3

High-throughput

0.479

High

218762

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.479

High

242902

PRKN
E3 ubiquitin-protein ligase parkin

1

17

High-throughput

0.479

High

257502

PAGE4
P antigen family member 4

1

1

High-throughput

0.479

High

294319

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.479

High

320050

UFL1
E3 UFM1-protein ligase 1

1

5

High-throughput

0.479

High

325106

HEXI1
Protein HEXIM1

1

5

High-throughput

0.479

High

375942

RASK
GTPase KRas

1

3

High-throughput

0.479

High

396929

ESR1
Estrogen receptor

1

18

High-throughput

0.479

High

406633

MYCN
N-myc proto-oncogene protein

1

15

High-throughput

0.479

High

412598

NTRK1
High affinity nerve growth factor receptor

1

13

High-throughput

0.479

High

414603

P53
Cellular tumor antigen p53

1

7

High-throughput

0.479

High

447859

TPM3
Tropomyosin alpha-3 chain

1

3

High-throughput

0.479

High

464211

TPM2
Tropomyosin beta chain

1

3

High-throughput

0.479

High

468794

HS90B
Heat shock protein HSP 90-beta

1

11

High-throughput

0.479

High

473076

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

20

High-throughput

0.479

High

504974

H2AB2
Histone H2A-Bbd type 2/3

1

13

High-throughput

0.479

High

607102

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

610047

VGFR1
Vascular endothelial growth factor receptor 1

1

7

High-throughput

0.479

High

657681

GCSP
Glycine dehydrogenase

1

3

High-throughput

0.479

High

683893

MOES
Moesin

1

4

High-throughput

0.479

High

720321

UFO
Tyrosine-protein kinase receptor UFO

1

5

High-throughput

0.479

High

749135

RL9
Large ribosomal subunit protein uL6

1

3

High-throughput

0.479

High

794624

RBMX
RNA-binding motif protein, X chromosome

1

11

High-throughput

0.479

High

831414

CCNF
Cyclin-F

1

6

High-throughput

0.479

High

879459

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

5

High-throughput

0.479

High

900154

FXR1
RNA-binding protein FXR1

1

8

High-throughput

0.479

High

905134

MECP2
Methyl-CpG-binding protein 2

1

12

High-throughput

0.479

High

971068

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

11

High-throughput

0.479

High

995476

TPM4
Tropomyosin alpha-4 chain

1

3

High-throughput

0.479

High

1029941

RUNX1
Runt-related transcription factor 1

1

2

High-throughput

0.479

High

1035908

KIF23
Kinesin-like protein KIF23

1

11

High-throughput

0.479

High

1040373

DYST
Dystonin

1

3

High-throughput

0.479

High

1067710

EP300
Histone acetyltransferase p300

1

15

High-throughput

0.479

High

1092240

NFX1
Transcriptional repressor NF-X1

1

10

High-throughput

0.479

High

1096220

TADBP
TAR DNA-binding protein 43

1

14

High-throughput

0.479

High

1101024

G3BP1
Ras GTPase-activating protein-binding protein 1

1

10

Small-scale

0.479

High

1107201

BIRC3
Baculoviral IAP repeat-containing protein 3

1

10

High-throughput

0.479

High

1117476

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

4

High-throughput

0.479

High

1127157

RBM39
RNA-binding protein 39

1

13

High-throughput

0.479

High

1138624

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

13

High-throughput

0.479

High

1141929

EEA1
Early endosome antigen 1

1

14

High-throughput

0.479

High

1146821

PCBP1
Poly(rC)-binding protein 1

1

10

High-throughput

0.479

High

1156856

E2F4
Transcription factor E2F4

1

2

High-throughput

0.479

High

1161665

IF16
Gamma-interferon-inducible protein 16

1

14

High-throughput

0.479

High

1178370

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

1194372

LARP7
La-related protein 7

1

20

High-throughput

0.479

High

1207442

HABP4
Intracellular hyaluronan-binding protein 4

1

9

High-throughput

0.479

High

1215823

RC3H1
Roquin-1

1

11

High-throughput

0.479

High

1235520

IFIX
Pyrin and HIN domain-containing protein 1

1

14

High-throughput

0.479

High

1252385

MEX3B
RNA-binding protein MEX3B

1

4

High-throughput

0.479

High

1271854

MEPCE
7SK snRNA methylphosphate capping enzyme

1

4

High-throughput

0.479

High

1275671

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

13

High-throughput

0.479

High

1276779

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

11

High-throughput

0.479

High

1281608

SLN11
Schlafen family member 11

1

7

High-throughput

0.479

High

1294568

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

6

Small-scale

0.479

High

1294917

ZGRF1
5'-3' DNA helicase ZGRF1

1

8

High-throughput

0.479

High

1310646

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

7

High-throughput

0.479

High

1330931

CGAS
Cyclic GMP-AMP synthase

1

6

High-throughput

0.479

High

1334903

SERB1
SERPINE1 mRNA-binding protein 1

1

9

High-throughput

0.479

High

1352746

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

4

High-throughput

0.479

High

1357555

DCAF4
DDB1- and CUL4-associated factor 4

1

3

High-throughput

0.479

High

1367254

ESR2
Estrogen receptor beta

1

17

High-throughput

0.479

High

1368377

REQU
Zinc finger protein ubi-d4

1

16

High-throughput

0.479

High

1370241

DAZL
Deleted in azoospermia-like

1

6

High-throughput

0.479

High

1381719

FAKD4
FAST kinase domain-containing protein 4

1

4

High-throughput

0.479

High

1382839

FUBP1
Far upstream element-binding protein 1

1

12

High-throughput

0.479

High

1383070

LRC59
Leucine-rich repeat-containing protein 59

1

4

High-throughput

0.479

High

1388403

MTEF3
Transcription termination factor 3, mitochondrial

1

1

High-throughput

0.479

High

1397420

CI072
Guanine nucleotide exchange factor C9orf72

1

3

High-throughput

0.479

High

1411706

RIOK1
Serine/threonine-protein kinase RIO1

1

6

High-throughput

0.479

High

1420358

TRI31
E3 ubiquitin-protein ligase TRIM31

1

15

High-throughput

0.479

High

1429565

LSG1
Large subunit GTPase 1 homolog

1

8

High-throughput

0.479

High

1432155

PKHA4
Pleckstrin homology domain-containing family A member 4

1

11

High-throughput

0.479

High

1432157

ECT2
Protein ECT2

1

8

High-throughput

0.479

High

1432159

RC3H2
Roquin-2

1

14

High-throughput

0.479

High

1432160

MOV10
Helicase MOV-10

1

8

High-throughput

0.479

High

1432161

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

1

High-throughput

0.479

High

1432163

BRD7
Bromodomain-containing protein 7

1

18

High-throughput

0.479

High

1432165

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

14

High-throughput

0.479

High

1432169

WWOX
WW domain-containing oxidoreductase

1

3

High-throughput

0.479

High

1432170

HECW2
E3 ubiquitin-protein ligase HECW2

1

10

High-throughput

0.479

High

1432172

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

1432180

RL26L
Ribosomal protein uL24-like

1

9

High-throughput

0.479

High

1432185

MAFB
Transcription factor MafB

1

12

High-throughput

0.479

High

1432186

NS1BP
Influenza virus NS1A-binding protein

1

3

Small-scale

0.479

High

688312

TTP
mRNA decay activator protein ZFP36

1

0

Small-scale

0.460

High

378342

IFN14
Interferon alpha-14

1

0

High-throughput

0.458

High

1119527

PEBB
Core-binding factor subunit beta

1

0

High-throughput

0.458

High

1161057

FSCN1
Fascin

1

0

High-throughput

0.458

High

1258387

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.458

High

1394797

CK5P3
CDK5 regulatory subunit-associated protein 3

1

0

High-throughput

0.458

High

1431534

VP33B
Vacuolar protein sorting-associated protein 33B

1

0

High-throughput

0.458

High

1432162

PPA6
Lysophosphatidic acid phosphatase type 6

1

0

High-throughput

0.458

High

1148236

TLR1
Toll-like receptor 1

1

2

Small-scale

0.457

High

47574

RPSA2
Small ribosomal subunit protein uS2B

1

12

High-throughput

0.445

High

430351

JUN
Transcription factor Jun

1

11

High-throughput

0.445

High

530369

TAU
Microtubule-associated protein tau

1

8

High-throughput

0.445

High

649421

H1T
Histone H1t

1

20

High-throughput

0.445

High

765883

BMI1
Polycomb complex protein BMI-1

1

10

High-throughput

0.445

High

775309

FUS
RNA-binding protein FUS

1

18

High-throughput

0.445

High

860359

RS9
Small ribosomal subunit protein uS4

1

10

Small-scale

0.445

High

942878

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

5

High-throughput

0.445

High

952341

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

19

High-throughput

0.445

High

1006705

SRPK2
SRSF protein kinase 2

1

20

High-throughput

0.445

High

1056969

FMR1
Fragile X messenger ribonucleoprotein 1

1

8

High-throughput

0.445

High

1209648

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

9

High-throughput

0.445

High

1226267

CP135
Centrosomal protein of 135 kDa

1

5

High-throughput

0.445

High

1326087

RYBP
RING1 and YY1-binding protein

1

2

High-throughput

0.445

High

1340200

ARK74
Aflatoxin B1 aldehyde reductase member 4

1

3

High-throughput

0.445

High

1229077

RNF43
E3 ubiquitin-protein ligase RNF43

1

1

High-throughput

0.437

High

1233945

Q6ICH2
single-stranded DNA cytosine deaminase

1

6

High-throughput

0.437

High

1432156

VIAAT
Vesicular inhibitory amino acid transporter

1

0

High-throughput

0.426

High

62596

S35F4
Solute carrier family 35 member F4

1

1

High-throughput

0.407

High

73451

B2CML4
single-stranded DNA cytosine deaminase

1

6

High-throughput

0.407

High

1430416

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

3

High-throughput

0.407

High

720041

HMOX2
Heme oxygenase 2

1

0

High-throughput

0.268

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025