HitPredict

Interactor 1: PBS2 (P08018)
MAP kinase kinase PBS2 (EC 2.7.12.2) (Polymyxin B resistance protein 2) (Suppressor of fluoride sensitivity 4)
Gene: PBS2

Interactor 2: HOG1 (P32485)
Mitogen-activated protein kinase HOG1 (MAP kinase HOG1) (EC 2.7.11.24) (High osmolarity glycerol response protein 1)
Gene: HOG1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.972

The method score is based on:

Property Details
Experiments 9180081, 29738528, 18212044, 37120434, 21118957, 25825474, 32150787, 38270553, 21698101
Identification Methods pull down, affinity chromatography technology, enzymatic study, protein complementation assay
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase
Common GO terms GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0006972 - hyperosmotic response
GO:0007231 - osmosensory signaling pathway
and 1 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 668
Sc

1 435
+ Sp
+ Hs
+ Hs
+ Hs
+ At
+ At
+ At
+ Hs
+ Hs
+ At
+ At
+ Hs
+ Mm
+ Hs
+ Mm
+ Mm
+ At
+ At
+ At
+ At

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024