HitPredict

Interactor 1: SP1 (P08047)
Transcription factor Sp1
Gene: SP1

Interactor 2: NCOR2 (Q9Y618)
Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor)
Gene: NCOR2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.573

Property	Details
Experiments	15878880
Identification Methods	two hybrid, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0017053 - transcription repressor complex and 1 others more... GO:0042826 - histone deacetylase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 785 Hs			1 2514
+	Hs
		317047 KLF8_HUMAN (367-708): 1.37e-64: 221: 26.02		NCOR2_HUMAN (1-2514): 0: 908: 100.00
+	Hs
		1254974 SP7_HUMAN (604-708): 2.55e-38: 150: 68.22		NCOR2_HUMAN (1-2514): 0: 908: 100.00
+	Hs
		1355815 KLF15_HUMAN (624-709): 4.31e-30: 125: 63.95		NCOR2_HUMAN (1-2514): 0: 908: 100.00
+	Hs
		261376 SP1_HUMAN (1-785): 7.23e-168: 506: 100.00		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Hs
		261553 SP7_HUMAN (604-708): 2.55e-38: 150: 68.22		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Hs
		261608 KLF15_HUMAN (624-709): 4.31e-30: 125: 63.95		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Hs
		435145 SP1_HUMAN (1-785): 7.23e-168: 506: 100.00		TITIN_HUMAN (1125-2056): 5.55e-11: 70.9: 8.61
+	Hs
		1238812 ZN383_HUMAN (443-765): 7.49e-94: 303: 17.47		RCOR3_HUMAN (351-810): 1.25e-41: 163: 20.65
+	Hs
		1254955 SP7_HUMAN (604-708): 2.55e-38: 150: 68.22		RCOR1_HUMAN (388-705): 2.51e-45: 174: 22.05
+	Hs
		316970 KLF8_HUMAN (367-708): 1.37e-64: 221: 26.02		MINT_HUMAN (80-1321): 6.8e-20: 100: 8.11
+	Hs
		317044 KLF8_HUMAN (367-708): 1.37e-64: 221: 26.02		PRC2C_HUMAN (1-1819): 3.07e-18: 94.7: 7.02
+	Hs
		316969 KLF8_HUMAN (367-708): 1.37e-64: 221: 26.02		CIC_HUMAN (7-2131): 8.47e-18: 93.5: 9.33
+	Hs
		1254944 SP7_HUMAN (604-708): 2.55e-38: 150: 68.22		RCOR3_HUMAN (351-810): 1.25e-41: 163: 20.65
+	Hs
		1254895 SP7_HUMAN (604-708): 2.55e-38: 150: 68.22		CIC_HUMAN (7-2131): 8.47e-18: 93.5: 9.33
+	Hs
		1243829 SP7_HUMAN (604-708): 2.55e-38: 150: 68.22		KMT2C_HUMAN (679-1264): 4.24e-16: 88: 11.93
+	Hs
		997548 ZN543_HUMAN (319-496): 1.97e-18: 91.8: 8.20		SRRM2_HUMAN (11-1905): 4.06e-30: 133: 8.95
+	Hs
		1315419 KLF16_HUMAN (624-708): 2.53e-33: 130: 63.53		PRC2C_HUMAN (1-1819): 3.07e-18: 94.7: 7.02
+	Hs
		1355809 KLF15_HUMAN (624-709): 4.31e-30: 125: 63.95		PRC2C_HUMAN (1-1819): 3.07e-18: 94.7: 7.02
+	Hs
		1300982 KLF15_HUMAN (624-709): 4.31e-30: 125: 63.95		CIC_HUMAN (7-2131): 8.47e-18: 93.5: 9.33
+	Hs
		1243850 KLF15_HUMAN (624-709): 4.31e-30: 125: 63.95		KMT2C_HUMAN (679-1264): 4.24e-16: 88: 11.93