Protein: CDC53
Cell division control protein 53 (Cullin-A) (E3 ubiquitin ligase complex SCF subunit CDC53)

Gene: CDC53
Organism: Saccharomyces cerevisiae S288C
Interactions: 141
UniProt ID: Q12018

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000409 - regulation of transcription by galactose
GO:0000781 - chromosome, telomeric region
GO:0003688 - DNA replication origin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

910801

SKP1
Suppressor of kinetochore protein 1

28

20

Small-scale

0.993

High

1062881

RBX1
RING-box protein HRT1

16

20

Small-scale

0.986

High

460748

CDC4
Cell division control protein 4

15

20

Small-scale

0.985

High

574823

UBC3
Ubiquitin-conjugating enzyme E2-34 kDa

14

20

Small-scale

0.984

High

666716

GRR1
SCF E3 ubiquitin ligase complex F-box protein GRR1

13

19

Small-scale

0.982

High

809301

MET30
F-box protein MET30

10

20

Small-scale

0.978

High

1084106

DCN1
Defective in cullin neddylation protein 1

6

20

Small-scale

0.962

High

864014

DAS1
F-box protein DAS1

6

1

Small-scale

0.948

High

1046842

UFO1
Ubiquitin ligase complex F-box protein UFO1

10

0

Small-scale

0.925

High

1064364

DIA2
Protein DIA2

5

0

Small-scale

0.871

High

1044298

RUB1
NEDD8-like protein RUB1

4

20

Small-scale

0.860

High

1052936

MDM30
Mitochondrial distribution and morphology protein 30

3

0

Small-scale

0.800

High

912395

UBC12
NEDD8-conjugating enzyme UBC12

2

20

Small-scale

0.767

High

1084108

CSN5
COP9 signalosome complex subunit 5

2

14

Small-scale

0.757

High

798637

SAF1
SCF-associated factor 1

6

1

Small-scale

0.736

High

1084104

HRT3
F-box protein HRT3

5

2

Small-scale

0.710

High

1056367

YD306
F-box protein YDR306C

4

1

Small-scale

0.686

High

1055300

YL352
F-box protein YLR352W

5

0

Small-scale

0.685

High

1056520

UBX5
UBX domain-containing protein 5

3

5

Small-scale

0.653

High

797373

AMN1
Antagonist of mitotic exit network protein 1

3

20

Small-scale

0.642

High

781502

HEL1
E3 ubiquitin-protein ligase HEL1

1

14

Small-scale

0.621

High

1042685

SLD5
DNA replication complex GINS protein SLD5

3

0

Small-scale

0.619

High

801187

SIC1
Protein SIC1

2

0

Small-scale

0.619

High

1084103

RPN5
26S proteasome regulatory subunit RPN5

1

20

High-throughput

0.618

High

757910

UBX1
UBX domain-containing protein 1

2

9

Small-scale

0.614

High

843221

SKP2
F-box protein SKP2

1

0

Small-scale

0.614

High

632443

CG12
G1/S-specific cyclin CLN2

2

10

Small-scale

0.601

High

440979

CDC7
Cell division control protein 7

2

20

Small-scale

0.595

High

1044287

YD131
F-box protein YDR131C

2

1

Small-scale

0.595

High

580213

HSC82
ATP-dependent molecular chaperone HSC82

2

19

High-throughput

0.594

High

916753

UFD1
Ubiquitin fusion degradation protein 1

2

1

Small-scale

0.586

High

481803

HSP73
Heat shock protein SSA3

2

14

High-throughput

0.584

High

514876

RS18A
Small ribosomal subunit protein uS13A

2

5

High-throughput

0.584

High

680140

CDC48
Cell division control protein 48

2

12

Small-scale

0.584

High

1040258

GDE1
Glycerophosphocholine phosphodiesterase GDE1

1

14

High-throughput

0.575

High

1053148

UCC1
F-box protein UCC1

2

0

Small-scale

0.569

High

815356

PAC2
Protein PAC2

1

8

Small-scale

0.561

High

1084105

CSN10
COP9 signalosome complex subunit 10

2

0

Small-scale

0.559

High

480006

PRTB
Cerevisin

2

2

High-throughput

0.549

High

1084107

ERG27
3-keto-steroid reductase ERG27

2

2

Small-scale

0.543

High

417191

VDAC1
Non-selective voltage-gated ion channel 1

1

1

High-throughput

0.536

High

596938

PDC5
Pyruvate decarboxylase isozyme 2

1

3

High-throughput

0.536

High

684538

PDC6
Pyruvate decarboxylase isozyme 3

1

3

High-throughput

0.536

High

763039

SPT7
SAGA complex subunit SPT7

1

17

High-throughput

0.536

High

1042394

GCN5
Histone acetyltransferase GCN5

1

16

High-throughput

0.536

High

763238

PP2C1
Protein phosphatase 2C homolog 1

1

0

High-throughput

0.513

High

393489

HSP82
ATP-dependent molecular chaperone HSP82

1

19

High-throughput

0.500

High

439446

PDC1
Pyruvate decarboxylase isozyme 1

1

3

High-throughput

0.500

High

518417

IF4A
ATP-dependent RNA helicase eIF4A

1

20

High-throughput

0.500

High

550775

INO1
Inositol-3-phosphate synthase

1

2

High-throughput

0.500

High

592558

VATB
V-type proton ATPase subunit B

1

6

High-throughput

0.500

High

626915

HSP60
Heat shock protein 60, mitochondrial

1

10

High-throughput

0.500

High

710030

BMH1
Protein BMH1

1

3

High-throughput

0.500

High

1064100

SGT1
Protein SGT1

1

0

Small-scale

0.493

High

1065628

THI21
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21

1

3

High-throughput

0.489

High

754454

NPL4
Nuclear protein localization protein 4

1

1

Small-scale

0.481

High

1044603

HMO1
High mobility group protein 1

1

6

Small-scale

0.481

High

432372

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.479

High

149996

RS9A
Small ribosomal subunit protein uS4A

1

4

High-throughput

0.479

High

382401

H4
Histone H4

1

6

High-throughput

0.479

High

435420

RS3
Small ribosomal subunit protein uS3

1

6

High-throughput

0.479

High

561259

CG13
G1/S-specific cyclin CLN3

1

6

Small-scale

0.479

High

594620

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.479

High

632400

CG11
G1/S-specific cyclin CLN1

1

13

Small-scale

0.479

High

667153

CG23
G2/mitotic-specific cyclin-3

1

3

Small-scale

0.479

High

671218

SIS1
Protein SIS1

1

8

High-throughput

0.479

High

727382

HS104
Heat shock protein 104

1

2

High-throughput

0.479

High

778577

RS27A
Small ribosomal subunit protein eS27A

1

3

High-throughput

0.479

High

779366

CENPA
Histone H3-like centromeric protein CSE4

1

6

Small-scale

0.479

High

792296

GBLP
Small ribosomal subunit protein RACK1

1

20

High-throughput

0.479

High

800829

RCK2
Serine/threonine-protein kinase RCK2

1

12

High-throughput

0.479

High

802434

RS20
Small ribosomal subunit protein uS10

1

6

High-throughput

0.479

High

803710

RPN1
26S proteasome regulatory subunit RPN1

1

5

Small-scale

0.479

High

806828

RPN10
26S proteasome regulatory subunit RPN10

1

2

Small-scale

0.479

High

808564

TEM1
Protein TEM1

1

6

Small-scale

0.479

High

924578

ADE
Adenine deaminase

1

3

High-throughput

0.479

High

963778

H3
Histone H3

1

6

High-throughput

0.479

High

1026850

CDC14
Tyrosine-protein phosphatase CDC14

1

6

Small-scale

0.479

High

1033902

PRS8
26S proteasome regulatory subunit 8 homolog

1

7

Small-scale

0.479

High

1046844

METX
Putative cystathionine gamma-synthase YML082W

1

1

High-throughput

0.479

High

1084101

SCC1
Sister chromatid cohesion protein 1

1

1

High-throughput

0.479

High

1084109

CMR1
DNA damage-binding protein CMR1

1

20

High-throughput

0.479

High

797591

FZO1
Mitofusin FZO1

1

0

Small-scale

0.460

High

708458

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

735213

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

818430

DDI1
DNA damage-inducible protein 1

1

0

Small-scale

0.458

High

826911

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

1044819

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

1059397

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

1084100

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

1084102

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

812832

RCY1
Recyclin-1

1

1

Small-scale

0.457

High

359539

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

6

High-throughput

0.457

High

452984

ATPA
ATP synthase subunit alpha, mitochondrial

1

6

High-throughput

0.457

High

555168

G6PI
Glucose-6-phosphate isomerase

1

1

High-throughput

0.457

High

613647

ADT2
ADP,ATP carrier protein 2

1

14

High-throughput

0.457

High

734228

EF2
Elongation factor 2

1

8

High-throughput

0.457

High

1062752

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

3

High-throughput

0.457

High

366068

CBPY
Carboxypeptidase Y

1

1

High-throughput

0.445

High

525453

HSP71
Heat shock protein SSA1

1

14

High-throughput

0.445

High

546632

SSB1
Ribosome-associated molecular chaperone SSB1

1

15

High-throughput

0.445

High

760372

BMH2
Protein BMH2

1

3

High-throughput

0.445

High

794736

SEA4
SEH-associated protein 4

1

1

High-throughput

0.445

High

798345

ENP1
Essential nuclear protein 1

1

1

High-throughput

0.445

High

802811

OSH3
Oxysterol-binding protein homolog 3

1

3

High-throughput

0.445

High

813378

PRP39
Pre-mRNA-processing factor 39

1

12

High-throughput

0.445

High

816462

HSP7E
Heat shock protein SSC3, mitochondrial

1

20

High-throughput

0.445

High

820049

SSB2
Ribosome-associated molecular chaperone SSB2

1

15

High-throughput

0.445

High

1061503

CDC45
Cell division control protein 45

1

1

High-throughput

0.445

High

511868

RS24A
Small ribosomal subunit protein eS24A

1

5

Small-scale

0.439

High

410383

RL25
Large ribosomal subunit protein uL23

1

6

High-throughput

0.437

High

442157

RS14A
Small ribosomal subunit protein uS11A

1

9

High-throughput

0.437

High

503289

RS22A
Small ribosomal subunit protein uS8A

1

6

High-throughput

0.437

High

512704

RS6A
Small ribosomal subunit protein eS6A

1

5

High-throughput

0.437

High

689710

RS7A
Small ribosomal subunit protein eS7A

1

4

High-throughput

0.437

High

795257

NU170
Nucleoporin NUP170

1

3

High-throughput

0.437

High

1025058

NUM1
Nuclear migration protein NUM1

1

20

High-throughput

0.437

High

1064814

RS10A
Small ribosomal subunit protein eS10A

1

4

High-throughput

0.437

High

510984

IPB2
Protease B inhibitor 2

1

0

High-throughput

0.426

High

805739

NDT80
Meiosis-specific transcription factor NDT80

1

0

High-throughput

0.426

High

818555

YEY6
MYG1 protein YER156C

1

0

High-throughput

0.426

High

884433

CTR1
Copper transport protein CTR1

1

0

High-throughput

0.426

High

1028013

STP1
Transcription factor STP1

1

0

High-throughput

0.426

High

1044626

CSN9
COP9 signalosome complex subunit 9

1

0

High-throughput

0.426

High

367411

CISY1
Citrate synthase, mitochondrial

1

3

High-throughput

0.407

High

577237

SEC63
Protein translocation protein SEC63

1

12

High-throughput

0.407

High

648408

SYMM
Methionine--tRNA ligase, mitochondrial

1

6

High-throughput

0.407

High

720856

ITR1
Myo-inositol transporter 1

1

2

High-throughput

0.407

High

866251

IML1
Vacuolar membrane-associated protein IML1

1

8

High-throughput

0.407

High

1059563

ATG20
Autophagy-related protein 20

1

3

High-throughput

0.407

High

1084110

LAG2
Cullin-associated NEDD8-dissociated protein 1 homolog

3

0

Small-scale

0.363

High

916854

ZIP2
Protein ZIP2

2

0

Small-scale

0.310

High

1053923

BOP2
Protein BOP2

2

0

High-throughput

0.310

High

763786

CBF3C
Centromere DNA-binding protein complex CBF3 subunit C

1

0

Small-scale

0.261

Low

94593

STE2
Pheromone alpha factor receptor

1

0

High-throughput

0.251

Low

797827

CS111
F-box protein COS111

1

0

Small-scale

0.251

Low

533498

TIR1
Cold shock-induced protein TIR1

1

0

Small-scale

0.249

Low

812742

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

1018189

YD274
Uncharacterized protein YDR274C

1

0

High-throughput

0.238

Low

737995

KRE6
Beta-glucan synthesis-associated protein KRE6

1

0

High-throughput

0.232

Low

794071

KTR4
Probable mannosyltransferase KTR4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025