HitPredict

Interactor 1: IGF1R (P08069)
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Gene: IGF1R

Interactor 2: ENPL (P14625)
Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog)
Gene: HSP90B1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	27684187, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0016020 - membrane GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1367 Hs			1 803
+	Hs
		435497 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		431438 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Hs
		411287 INSR_HUMAN (32-1365): 0: 1219: 56.54		ENPL_HUMAN (1-803): 0: 1073: 100.00
+	Rn
		544887 INSR_RAT (20-1365): 0: 1210: 55.45		ENPL_RAT (1-803): 0: 1055: 95.03
+	Hs
		437855 INSRR_HUMAN (14-1310): 0: 1170: 55.26		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		431488 INSRR_HUMAN (14-1310): 0: 1170: 55.26		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Dm
		365430 INSR_DROME (12-1356): 0: 910: 32.97		HSP83_DROME (69-783): 0: 981: 45.74
+	Dm
		448254 INSR_DROME (12-1356): 0: 910: 32.97		Q9VAY2_DROME (16-751): 0: 919: 62.28
+	Hs
		438029 EPHA4_HUMAN (655-1342): 8.85e-179: 558: 23.12		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		431562 EPHA3_HUMAN (666-1311): 0: 564: 24.96		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Hs
		431692 EPHA4_HUMAN (655-1342): 8.85e-179: 558: 23.12		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Hs
		437918 EPHA2_HUMAN (653-1304): 6.11e-163: 516: 23.93		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		431561 EPHA2_HUMAN (653-1304): 6.11e-163: 516: 23.93		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Hs
		384200 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		ENPL_HUMAN (1-803): 0: 1073: 100.00
+	Hs
		438619 ALK_HUMAN (939-1304): 2.51e-75: 278: 39.12		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		432361 ALK_HUMAN (939-1304): 2.51e-75: 278: 39.12		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Hs
		438213 NTRK2_HUMAN (977-1256): 2.65e-70: 255: 43.95		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		384122 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		431901 NTRK2_HUMAN (977-1256): 2.65e-70: 255: 43.95		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Hs
		384111 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		HS90A_HUMAN (60-783): 0: 990: 45.34