HitPredict

Interactor 1: IGF1R (P08069)
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Gene: IGF1R

Interactor 2: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.91 1.00 0.959

The method score is based on:

Property Details
Experiments 8776723, 16113100, 7559507, 14764897, 24051437, 7541045, 15629149
Identification Methods two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation, far western blotting
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains SH2~fn3, PK_Tyr_Ser-Thr~SH2
Common GO terms GO:0005158 - insulin receptor binding
GO:0005886 - plasma membrane
GO:0008284 - positive regulation of cell population proliferation
GO:0008286 - insulin receptor signaling pathway
GO:0043066 - negative regulation of apoptotic process
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1367
Hs

1 583
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Rn
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Rn
+ Hs
+ Hs
+ Rn
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024