HitPredict

Interactor 1: IGF1R (P08069)
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Gene: IGF1R

Interactor 2: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.848

Property	Details
Experiments	27684187, 17353931, 15324660
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0007165 - signal transduction GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1367 Hs			1 247
+	Hs
		435597 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		435553 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		435604 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		435542 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		435554 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16
+	Hs
		411315 INSR_HUMAN (32-1365): 0: 1219: 56.54		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		411316 INSR_HUMAN (32-1365): 0: 1219: 56.54		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16
+	Dm
		448232 INSR_DROME (12-1356): 0: 910: 32.97		1433Z_DROME (2-242): 1.36e-108: 314: 74.69
+	At
		965369 CLV1_ARATH (340-1268): 0: 585: 15.24		14332_ARATH (4-244): 1.39e-141: 398: 61.32
+	Hs
		384604 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		169169 MUSK_HUMAN (993-1262): 8.25e-69: 251: 42.96		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		384598 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	Hs
		384689 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		1433F_HUMAN (1-246): 2.5e-135: 382: 86.99
+	Hs
		384357 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		384623 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		674348 UFO_HUMAN (790-1271): 9.27e-68: 249: 32.10		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		674386 UFO_HUMAN (790-1271): 9.27e-68: 249: 32.10		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		384306 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		384358 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16
+	Hs
		169164 MUSK_HUMAN (993-1262): 8.25e-69: 251: 42.96		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16