Protein: SET2
Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.359) (Lysine N-methyltransferase 3) (SET domain-containing protein 2)

Gene: SET2
Organism: Saccharomyces cerevisiae S288C
Interactions: 170
UniProt ID: P46995

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0006283 - transcription-coupled nucleotide-excision repair

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

402043

RPB1
DNA-directed RNA polymerase II subunit RPB1

9

9

Small-scale

0.971

High

863938

H3
Histone H3

6

20

Small-scale

0.941

High

382185

H4
Histone H4

4

7

Small-scale

0.878

High

594443

RPB3
DNA-directed RNA polymerase II subunit RPB3

7

1

Small-scale

0.736

High

470551

RPB2
DNA-directed RNA polymerase II subunit RPB2

6

2

Small-scale

0.721

High

632098

RPB4
DNA-directed RNA polymerase II subunit RPB4

3

1

Small-scale

0.640

High

632180

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

3

1

Small-scale

0.640

High

699962

RPB9
DNA-directed RNA polymerase II subunit RPB9

3

1

Small-scale

0.640

High

757335

RPB7
DNA-directed RNA polymerase II subunit RPB7

3

1

Small-scale

0.640

High

792121

GBLP
Small ribosomal subunit protein RACK1

1

12

High-throughput

0.618

High

806935

RPB11
DNA-directed RNA polymerase II subunit RPB11

3

0

Small-scale

0.613

High

823714

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

3

0

Small-scale

0.613

High

545372

SSB1
Ribosome-associated molecular chaperone SSB1

2

6

High-throughput

0.601

High

441991

RS14A
Small ribosomal subunit protein uS11A

2

2

High-throughput

0.595

High

863932

UTP22
U3 small nucleolar RNA-associated protein 22

2

1

High-throughput

0.588

High

694579

SPT5
Transcription elongation factor SPT5

2

5

High-throughput

0.584

High

863948

POB3
FACT complex subunit POB3

2

3

High-throughput

0.584

High

863944

GCN5
Histone acetyltransferase GCN5

1

20

Small-scale

0.578

High

419791

H2A2
Histone H2A.2

1

12

High-throughput

0.575

High

863918

SET2
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

19

High-throughput

0.575

High

863973

H2AZ
Histone H2A.Z

1

12

High-throughput

0.575

High

435192

RS3
Small ribosomal subunit protein uS3

2

2

High-throughput

0.571

High

863966

RS10A
Small ribosomal subunit protein eS10A

2

5

High-throughput

0.571

High

577561

CYC8
General transcriptional corepressor CYC8

1

9

Small-scale

0.561

High

863962

BRE1
E3 ubiquitin-protein ligase BRE1

1

9

Small-scale

0.561

High

632271

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

2

0

High-throughput

0.559

High

632355

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

2

0

Small-scale

0.559

High

645070

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

2

0

High-throughput

0.559

High

748299

SPT4
Transcription elongation factor SPT4

2

0

High-throughput

0.559

High

527032

HSP72
Heat shock protein SSA2

2

6

High-throughput

0.552

High

863949

RCO1
Transcriptional regulatory protein RCO1

1

20

High-throughput

0.515

High

863970

YRA1
RNA annealing protein YRA1

1

11

High-throughput

0.515

High

368001

ENO2
Enolase 2

1

4

High-throughput

0.501

High

416258

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

4

High-throughput

0.501

High

636596

PSA7
Probable proteasome subunit alpha type-7

1

5

High-throughput

0.501

High

655588

TKT1
Transketolase 1

1

5

High-throughput

0.501

High

757629

SIP2
SNF1 protein kinase subunit beta-2

1

1

High-throughput

0.501

High

863921

YJ66
Uncharacterized oxidoreductase YJR096W

1

1

High-throughput

0.501

High

863936

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

10

High-throughput

0.501

High

863946

RUB1
NEDD8-like protein RUB1

1

4

High-throughput

0.501

High

863968

HOSM
Homocitrate synthase, mitochondrial

1

1

High-throughput

0.501

High

602129

SPO12
Sporulation-specific protein 12

1

0

Small-scale

0.486

High

750715

PRS6A
26S proteasome regulatory subunit 6A

1

6

High-throughput

0.481

High

755260

NUF2
Kinetochore protein NUF2

1

3

High-throughput

0.481

High

844466

GZF3
Protein GZF3

1

8

High-throughput

0.481

High

863934

PRS10
26S proteasome subunit RPT4

1

5

High-throughput

0.481

High

863952

RPN7
26S proteasome regulatory subunit RPN7

1

1

High-throughput

0.481

High

863967

NOP53
Ribosome biogenesis protein NOP53

1

2

High-throughput

0.481

High

150221

YL269
Putative uncharacterized protein YLR269C

1

0

High-throughput

0.480

High

370442

IPA3
Protease A inhibitor 3

1

0

High-throughput

0.480

High

534191

PCKA
Phosphoenolpyruvate carboxykinase

1

0

High-throughput

0.480

High

541285

HEM6
Oxygen-dependent coproporphyrinogen-III oxidase

1

0

High-throughput

0.480

High

689777

INO2
Protein INO2

1

0

Small-scale

0.480

High

743823

FRDS
Fumarate reductase 1

1

0

High-throughput

0.480

High

793226

YBQ6
Uncharacterized glycosyl hydrolase YBR056W

1

0

High-throughput

0.480

High

809353

STM1
Suppressor protein STM1

1

0

High-throughput

0.480

High

863603

GON7
EKC/KEOPS complex subunit GON7

1

0

High-throughput

0.480

High

863927

RIR4
Ribonucleoside-diphosphate reductase small chain 2

1

0

High-throughput

0.480

High

863933

YG2W
Uncharacterized protein YGR111W

1

0

High-throughput

0.480

High

863959

ARR2
Arsenical-resistance protein 2

1

0

High-throughput

0.480

High

149838

RS9A
Small ribosomal subunit protein uS4A

1

4

High-throughput

0.479

High

383775

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.479

High

410211

RL25
Large ribosomal subunit protein uL23

1

4

High-throughput

0.479

High

433717

RL26A
Large ribosomal subunit protein uL24A

1

3

High-throughput

0.479

High

436038

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

455137

RS19A
Small ribosomal subunit protein eS19A

1

3

High-throughput

0.479

High

503121

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.479

High

504289

RL31A
Large ribosomal subunit protein eL31A

1

5

High-throughput

0.479

High

512518

RS6A
Small ribosomal subunit protein eS6A

1

3

High-throughput

0.479

High

513088

RS8A
Small ribosomal subunit protein eS8A

1

2

High-throughput

0.479

High

514705

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

574807

UBC3
Ubiquitin-conjugating enzyme E2-34 kDa

1

4

Small-scale

0.479

High

661176

SPT6
Transcription elongation factor SPT6

1

5

High-throughput

0.479

High

674703

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.479

High

689536

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.479

High

736673

ASF1
Histone chaperone ASF1

1

2

Small-scale

0.479

High

739677

SPT16
FACT complex subunit SPT16

1

1

High-throughput

0.479

High

747449

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.479

High

753449

RS3A1
Small ribosomal subunit protein eS1A

1

4

High-throughput

0.479

High

778404

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.479

High

780376

ELF1
Transcription elongation factor 1

1

1

High-throughput

0.479

High

802252

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

818385

RTR1
RNA polymerase II subunit B1 CTD phosphatase RTR1

1

1

High-throughput

0.479

High

836545

T2FB
Transcription initiation factor IIF subunit beta

1

1

High-throughput

0.479

High

863937

ORC1
Origin recognition complex subunit 1

1

2

High-throughput

0.479

High

863940

NAM8
Protein NAM8

1

5

High-throughput

0.479

High

863942

MCE1
mRNA-capping enzyme subunit alpha

1

1

High-throughput

0.479

High

863943

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

863956

IWS1
Transcription factor SPN1

1

3

High-throughput

0.479

High

863969

SCC1
Sister chromatid cohesion protein 1

1

1

High-throughput

0.479

High

863971

BBP
Branchpoint-bridging protein

1

4

Small-scale

0.479

High

782366

RPF2
Ribosome biogenesis protein RPF2

1

1

High-throughput

0.470

High

749686

TYE7
Transcription factor TYE7

1

0

High-throughput

0.460

High

797889

CENPU
Inner kinetochore subunit AME1

1

0

High-throughput

0.460

High

807900

BFR1
Nuclear segregation protein BFR1

1

0

High-throughput

0.460

High

863922

NNF1
Kinetochore-associated protein NNF1

1

0

High-throughput

0.460

High

863945

VPS72
Vacuolar protein sorting-associated protein 72

1

0

High-throughput

0.460

High

863953

NKP2
Inner kinetochore subunit NKP2

1

0

High-throughput

0.460

High

863957

NDE1
Nuclear distribution protein nudE homolog 1

1

0

High-throughput

0.460

High

863960

HDA2
HDA1 complex subunit 2

1

0

High-throughput

0.460

High

707489

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

743530

RU1A
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.458

High

780832

MUD2
Splicing factor MUD2

1

0

Small-scale

0.458

High

826618

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

836528

T2FA
Transcription initiation factor IIF subunit alpha

1

0

High-throughput

0.458

High

863920

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.458

High

863925

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

863930

NSA1
Ribosome biogenesis protein NSA1

1

0

High-throughput

0.458

High

863947

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

863961

ASR1
Alcohol-sensitive RING finger protein 1

1

0

High-throughput

0.458

High

863964

IWR1
RNA polymerase II nuclear localization protein IWR1

1

0

High-throughput

0.458

High

863965

SGO1
Shugoshin

1

0

High-throughput

0.458

High

449143

CALM
Calmodulin

1

2

High-throughput

0.457

High

676876

YCC1
Putative uncharacterized protein YCL021W

1

1

High-throughput

0.457

High

736117

ARP2
Actin-related protein 2

1

3

High-throughput

0.457

High

863924

YPT11
GTP-binding protein YPT11

1

5

High-throughput

0.457

High

403558

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

6

High-throughput

0.445

High

435594

RS9B
Small ribosomal subunit protein uS4B

1

4

High-throughput

0.445

High

524383

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.445

High

585972

CSK21
Casein kinase II subunit alpha

1

12

High-throughput

0.445

High

645460

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.445

High

676116

MAS5
Mitochondrial protein import protein MAS5

1

4

High-throughput

0.445

High

676742

GBP2
Serine/arginine

1

6

High-throughput

0.445

High

684769

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.445

High

712605

RL8B
Large ribosomal subunit protein eL8B

1

5

High-throughput

0.445

High

727142

HS104
Heat shock protein 104

1

1

High-throughput

0.445

High

741860

HSP7F
Heat shock protein homolog SSE1

1

10

High-throughput

0.445

High

742886

HSP79
Heat shock protein homolog SSE2

1

10

High-throughput

0.445

High

794191

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

1

20

High-throughput

0.445

High

807101

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

3

High-throughput

0.445

High

811345

CAJ1
Protein CAJ1

1

6

High-throughput

0.445

High

816160

DPO5
rDNA transcriptional regulator POL5

1

2

High-throughput

0.445

High

819118

SSB2
Ribosome-associated molecular chaperone SSB2

1

6

High-throughput

0.445

High

826443

DJP1
DnaJ-like protein 1

1

6

High-throughput

0.445

High

863926

RL4B
Large ribosomal subunit protein uL4B

1

3

High-throughput

0.445

High

863941

CDC14
Tyrosine-protein phosphatase CDC14

1

6

High-throughput

0.445

High

863950

RRP5
rRNA biogenesis protein RRP5

1

8

High-throughput

0.445

High

863954

FKBP4
FK506-binding protein 4

1

3

High-throughput

0.445

High

863972

RUVB2
RuvB-like protein 2

1

7

High-throughput

0.445

High

758110

CASP
Protein CASP

1

10

High-throughput

0.439

High

816960

BIM1
Protein BIM1

1

1

High-throughput

0.439

High

863175

YPP1
Cargo-transport protein YPP1

1

0

High-throughput

0.426

High

427338

RLA0
Large ribosomal subunit protein uL10

1

2

High-throughput

0.407

High

671656

SCJ1
DnaJ-related protein SCJ1

1

3

High-throughput

0.407

High

752437

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.407

High

816273

HSP7E
Heat shock protein SSC3, mitochondrial

1

10

High-throughput

0.407

High

850639

ERJ5
ER-localized J domain-containing protein 5

1

5

High-throughput

0.407

High

850995

CSK2B
Casein kinase II subunit beta

1

4

High-throughput

0.407

High

863919

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.407

High

863923

HLJ1
Protein HLJ1

1

3

High-throughput

0.407

High

863928

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

1

High-throughput

0.407

High

701486

ACEA
Isocitrate lyase

1

0

High-throughput

0.269

Low

836166

OYE3
NADPH dehydrogenase 3

1

0

High-throughput

0.261

Low

863929

YGV4
Uncharacterized protein YGL204C

1

0

High-throughput

0.261

Low

863935

YNW6
Putative uncharacterized protein YNL226W

1

0

High-throughput

0.261

Low

863939

PURA
Adenylosuccinate synthetase

1

0

High-throughput

0.261

Low

863951

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

High-throughput

0.261

Low

863955

ATPK
ATP synthase subunit f, mitochondrial

1

0

High-throughput

0.261

Low

863958

OPT2
Oligopeptide transporter 2

1

0

High-throughput

0.261

Low

863963

DLHH
Putative carboxymethylenebutenolidase

1

0

High-throughput

0.261

Low

743870

YEF3
Uncharacterized protein YEL043W

1

0

High-throughput

0.251

Low

776758

YKF0
Uncharacterized protein YKL050C

1

0

High-throughput

0.251

Low

813810

MBO1
Gamma tubulin complex adapter SPC72

1

0

High-throughput

0.251

Low

818565

COG3
Conserved oligomeric Golgi complex subunit 3

1

0

High-throughput

0.251

Low

858502

STB2
Protein STB2

1

0

High-throughput

0.251

Low

863931

NNF2
Protein NNF2

1

0

High-throughput

0.251

Low

795071

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

863625

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low

825860

YIG0
Uncharacterized protein YIL060W

1

0

High-throughput

0.213

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025