HitPredict

Interactor 1: IGF1R (P08069)
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Gene: IGF1R

Interactor 2: RACK1 (P63244)
Small ribosomal subunit protein RACK1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Receptor of activated protein C kinase 1) [Cleaved into: Small ribosomal subunit protein RACK1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed) (Receptor of activated protein C kinase 1, N-terminally processed)]
Gene: RACK1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.931

Property	Details
Experiments	27684187, 11964397, 11884618, 35384245, 20871634, 16382134
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	WD40~fn3
Common GO terms	GO:0030335 - positive regulation of cell migration GO:0043025 - neuronal cell body GO:0071333 - cellular response to glucose stimulus
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1367 Hs			1 317
+	Hs
		411353 INSR_HUMAN (32-1365): 0: 1219: 56.54		RACK1_HUMAN (1-317): 2.18e-109: 322: 100.00
+	Hs
		929718 ALK_HUMAN (939-1304): 2.51e-75: 278: 39.12		RACK1_HUMAN (1-317): 2.18e-109: 322: 100.00
+	Hs
		666573 LTK_HUMAN (989-1319): 5.64e-75: 270: 40.11		RACK1_HUMAN (1-317): 2.18e-109: 322: 100.00
+	Hs
		384626 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		RACK1_HUMAN (1-317): 2.18e-109: 322: 100.00
+	Hs
		169170 MUSK_HUMAN (993-1262): 8.25e-69: 251: 42.96		RACK1_HUMAN (1-317): 2.18e-109: 322: 100.00
+	Hs
		384596 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		WDR5_HUMAN (3-219): 3.42e-62: 202: 26.70
+	Hs
		384438 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		LIS1_HUMAN (144-316): 6.1e-46: 162: 23.43
+	Hs
		674357 UFO_HUMAN (790-1271): 9.27e-68: 249: 32.10		LIS1_HUMAN (144-316): 6.1e-46: 162: 23.43
+	Hs
		609202 FGFR3_HUMAN (972-1266): 2.05e-63: 234: 38.44		LIS1_HUMAN (144-316): 6.1e-46: 162: 23.43
+	Hs
		1313658 ALK_HUMAN (939-1304): 2.51e-75: 278: 39.12		KTNB1_HUMAN (10-213): 1.19e-17: 85.5: 28.29
+	Hs
		385480 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		TBL1R_HUMAN (188-316): 1.53e-14: 76: 15.86