Protein: EIF3B
Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Cell cycle regulation and translation initiation protein) (Eukaryotic translation initiation factor 3 90 kDa subunit) (eIF3 p90) (Translation initiation factor eIF3 p90 subunit)

Gene: EIF3B, PRT1
Organism: Saccharomyces cerevisiae S288C
Interactions: 172
UniProt ID: P06103

Gene Ontology (top 5):
GO:0001732 - formation of cytoplasmic translation initiation complex
GO:0002183 - cytoplasmic translational initiation
GO:0003723 - RNA binding
GO:0003743 - translation initiation factor activity
GO:0005852 - eukaryotic translation initiation factor 3 complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

438486

EIF3G
Eukaryotic translation initiation factor 3 subunit G

16

4

Small-scale

0.988

High

438350

EIF3B
Eukaryotic translation initiation factor 3 subunit B

8

3

Small-scale

0.961

High

438421

EIF3A
Eukaryotic translation initiation factor 3 subunit A

19

7

Small-scale

0.768

High

438443

EIF3I
Eukaryotic translation initiation factor 3 subunit I

19

5

Small-scale

0.768

High

438424

IF5
Eukaryotic translation initiation factor 5

15

5

Small-scale

0.762

High

438401

EIF3C
Eukaryotic translation initiation factor 3 subunit C

14

5

Small-scale

0.761

High

438407

SUI1
Eukaryotic translation initiation factor eIF-1

8

2

Small-scale

0.748

High

438461

EIF2A
Eukaryotic translation initiation factor 2A

2

3

High-throughput

0.743

High

403296

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

2

3

Small-scale

0.737

High

438436

IF2P
Eukaryotic translation initiation factor 5B

6

1

Small-scale

0.730

High

438489

EIF3J
Eukaryotic translation initiation factor 3 subunit J

9

0

Small-scale

0.725

High

438376

CSK21
Casein kinase II subunit alpha

2

10

Small-scale

0.714

High

438358

IF2B
Eukaryotic translation initiation factor 2 subunit beta

4

3

Small-scale

0.683

High

438400

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

3

4

Small-scale

0.650

High

438418

GBLP
Small ribosomal subunit protein RACK1

4

3

Small-scale

0.619

High

438397

XPO1
Exportin-1

1

4

High-throughput

0.618

High

409831

RL25
Large ribosomal subunit protein uL23

1

2

High-throughput

0.618

High

434679

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.618

High

438357

PBS2
MAP kinase kinase PBS2

1

2

High-throughput

0.618

High

438388

GBP2
Serine/arginine

1

6

High-throughput

0.618

High

438452

TRM6
tRNA

3

0

Small-scale

0.613

High

438353

DED1
ATP-dependent RNA helicase DED1

2

2

High-throughput

0.611

High

438405

RSSA1
Small ribosomal subunit protein uS2A

2

3

High-throughput

0.611

High

438500

RS10A
Small ribosomal subunit protein eS10A

2

2

High-throughput

0.611

High

438381

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

2

1

Small-scale

0.601

High

438510

IF6
Eukaryotic translation initiation factor 6

2

1

High-throughput

0.601

High

438384

SIS1
Protein SIS1

2

4

High-throughput

0.588

High

438396

TF2B
Transcription initiation factor IIB

3

1

High-throughput

0.587

High

438430

IF1A
Eukaryotic translation initiation factor 1A

2

1

Small-scale

0.584

High

438482

RLI1
Translation initiation factor RLI1

2

4

Small-scale

0.584

High

438368

HSP71
Heat shock protein SSA1

3

5

High-throughput

0.578

High

438355

RS19A
Small ribosomal subunit protein eS19A

2

3

High-throughput

0.571

High

438431

CSK2C
Casein kinase II subunit beta'

2

1

High-throughput

0.567

High

438505

GLE1
mRNA export factor GLE1

1

4

Small-scale

0.561

High

435661

RS13
Small ribosomal subunit protein uS15

2

2

High-throughput

0.558

High

438360

RS22A
Small ribosomal subunit protein uS8A

2

3

High-throughput

0.558

High

149478

RS9A
Small ribosomal subunit protein uS4A

1

4

High-throughput

0.553

High

438379

CSK22
Casein kinase II subunit alpha'

1

11

Small-scale

0.553

High

438370

SSB1
Ribosome-associated molecular chaperone SSB1

2

5

High-throughput

0.549

High

438488

ERB1
Ribosome biogenesis protein ERB1

2

2

High-throughput

0.537

High

438465

BRE5
UBP3-associated protein BRE5

1

4

High-throughput

0.536

High

438365

RS8A
Small ribosomal subunit protein eS8A

2

2

High-throughput

0.533

High

391983

HSP82
ATP-dependent molecular chaperone HSP82

2

3

High-throughput

0.521

High

438479

UTP17
NET1-associated nuclear protein 1

1

4

High-throughput

0.515

High

438369

HSP72
Heat shock protein SSA2

2

5

High-throughput

0.504

High

438463

CWC22
Pre-mRNA-splicing factor CWC22

1

0

High-throughput

0.493

High

438466

ESF2
Pre-rRNA-processing protein ESF2

1

0

High-throughput

0.493

High

438361

RS28B
Small ribosomal subunit protein eS28B

1

1

High-throughput

0.489

High

438387

MAS5
Mitochondrial protein import protein MAS5

1

3

High-throughput

0.489

High

438393

RS5
Small ribosomal subunit protein uS7

1

1

High-throughput

0.489

High

438455

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.489

High

438457

RS7B
Small ribosomal subunit protein eS7B

1

4

High-throughput

0.489

High

438475

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

2

High-throughput

0.489

High

433335

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.479

High

438351

SC160
Protein SCP160

1

2

High-throughput

0.479

High

438354

IF4E
Eukaryotic translation initiation factor 4E

1

2

Small-scale

0.479

High

438372

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.479

High

438382

IF5A1
Eukaryotic translation initiation factor 5A-1

1

2

Small-scale

0.479

High

438394

RL16A
Large ribosomal subunit protein uL13A

1

2

High-throughput

0.479

High

438414

RS27A
Small ribosomal subunit protein eS27A

1

4

High-throughput

0.479

High

438415

EF1G2
Elongation factor 1-gamma 2

1

1

High-throughput

0.479

High

438420

OLA1
Obg-like ATPase 1

1

3

High-throughput

0.479

High

438433

DHH1
ATP-dependent RNA helicase DHH1

1

6

High-throughput

0.479

High

438437

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

8

Small-scale

0.479

High

438450

RLP7
Ribosome biogenesis protein RLP7

1

2

High-throughput

0.479

High

438462

PESC
Pescadillo homolog

1

1

High-throughput

0.479

High

438467

GIS2
Zinc finger protein GIS2

1

1

High-throughput

0.479

High

438476

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.479

High

438487

TMA64
Translation machinery-associated protein 64

1

2

High-throughput

0.479

High

438356

ARD1
N-terminal acetyltransferase A complex catalytic subunit ARD1

1

1

High-throughput

0.470

High

438439

BEM2
GTPase-activating protein BEM2/IPL2

1

1

High-throughput

0.470

High

438508

PRP46
Pre-mRNA-splicing factor PRP46

1

2

High-throughput

0.470

High

438366

RL18B
Large ribosomal subunit protein eL18B

1

0

High-throughput

0.458

High

438380

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

Small-scale

0.458

High

438459

PSP2
Protein PSP2

1

0

High-throughput

0.458

High

438496

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.458

High

438438

IF4F2
Eukaryotic initiation factor 4F subunit p130

1

10

Small-scale

0.445

High

438442

SSB2
Ribosome-associated molecular chaperone SSB2

1

5

High-throughput

0.445

High

383408

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.437

High

436259

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

1

High-throughput

0.437

High

438352

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.437

High

438362

RL31A
Large ribosomal subunit protein eL31A

1

2

High-throughput

0.437

High

438364

RS6A
Small ribosomal subunit protein eS6A

1

3

High-throughput

0.437

High

438367

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.437

High

438373

DPOLA
DNA polymerase alpha catalytic subunit A

1

1

High-throughput

0.437

High

438386

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.437

High

438395

RS7A
Small ribosomal subunit protein eS7A

1

4

High-throughput

0.437

High

438398

HS104
Heat shock protein 104

1

1

High-throughput

0.437

High

438408

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

1

High-throughput

0.437

High

438411

RS3A1
Small ribosomal subunit protein eS1A

1

3

High-throughput

0.437

High

438425

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.437

High

438434

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

438446

TM108
Protein TMA108

1

1

High-throughput

0.437

High

438449

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.437

High

438453

UTP10
U3 small nucleolar RNA-associated protein 10

1

1

High-throughput

0.437

High

438454

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

7

High-throughput

0.437

High

438458

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.437

High

438469

MDG1
Signal transduction protein MDG1

1

1

High-throughput

0.437

High

438472

FAP1
FKBP12-associated protein 1

1

3

High-throughput

0.437

High

438477

ULP1
Ubiquitin-like-specific protease 1

1

1

High-throughput

0.437

High

438501

NEW1
[NU+] prion formation protein 1

1

3

High-throughput

0.437

High

438502

KEL3
Kelch repeat-containing protein 3

1

1

High-throughput

0.437

High

438503

TMA46
Translation machinery-associated protein 46

1

1

High-throughput

0.437

High

438507

CSN10
COP9 signalosome complex subunit 10

1

1

Small-scale

0.437

High

438377

HSP26
Heat shock protein 26

1

0

High-throughput

0.426

High

438359

HSP73
Heat shock protein SSA3

1

5

High-throughput

0.407

High

438363

HSP77
Import motor subunit, mitochondrial

1

2

High-throughput

0.407

High

438371

TCPA
T-complex protein 1 subunit alpha

1

3

High-throughput

0.407

High

438374

SEC63
Protein translocation protein SEC63

1

1

High-throughput

0.407

High

438375

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.407

High

438378

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.407

High

438385

SCJ1
DnaJ-related protein SCJ1

1

3

High-throughput

0.407

High

438402

HSP7F
Heat shock protein homolog SSE1

1

8

High-throughput

0.407

High

438403

HSP79
Heat shock protein homolog SSE2

1

8

High-throughput

0.407

High

438409

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.407

High

438410

IXR1
Intrastrand cross-link recognition protein

1

1

High-throughput

0.407

High

438412

MDJ1
DnaJ homolog 1, mitochondrial

1

3

High-throughput

0.407

High

438426

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.407

High

438429

SSZ1
Ribosome-associated complex subunit SSZ1

1

3

High-throughput

0.407

High

438432

TCPG
T-complex protein 1 subunit gamma

1

2

High-throughput

0.407

High

438440

HSP7E
Heat shock protein SSC3, mitochondrial

1

2

High-throughput

0.407

High

438456

JJJ2
J protein JJJ2

1

3

High-throughput

0.407

High

438468

JJJ1
J protein JJJ1

1

4

High-throughput

0.407

High

438497

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

1

High-throughput

0.407

High

438445

RIC1
Guanine nucleotide exchange factor subunit RIC1

2

0

High-throughput

0.324

High

438491

ARPC3
Actin-related protein 2/3 complex subunit 3

2

0

High-throughput

0.313

High

438490

PUR8
Adenylosuccinate lyase

2

0

High-throughput

0.307

High

438506

HAT1
Histone acetyltransferase type B catalytic subunit

2

0

High-throughput

0.307

High

438447

CSN11
Cop9 signalosome complex subunit 11

1

0

Small-scale

0.301

High

438499

MCA1
Metacaspase-1

1

0

Small-scale

0.279

Low

404975

PUR3
Phosphoribosylglycinamide formyltransferase

1

0

High-throughput

0.269

Low

438383

DPB2
DNA polymerase epsilon subunit B

1

0

High-throughput

0.269

Low

438390

IMG2
Large ribosomal subunit protein mL49

1

0

High-throughput

0.269

Low

438399

DCUP
Uroporphyrinogen decarboxylase

1

0

High-throughput

0.269

Low

438404

KA122
Importin beta-like protein KAP122

1

0

High-throughput

0.269

Low

438413

OSH1
Oxysterol-binding protein homolog 1

1

0

High-throughput

0.269

Low

438435

MET10
Sulfite reductase [NADPH] flavoprotein component

1

0

High-throughput

0.269

Low

438441

CHZ1
Histone H2A.Z-specific chaperone CHZ1

1

0

High-throughput

0.269

Low

438451

FKH2
Fork head protein homolog 2

1

0

High-throughput

0.269

Low

438478

ARL3
ADP-ribosylation factor-like protein 3

1

0

High-throughput

0.269

Low

438492

IMB1
Importin subunit beta-1

1

0

High-throughput

0.269

Low

438495

ATG17
Autophagy-related protein 17

1

0

High-throughput

0.269

Low

438389

BUD23
18S rRNA

1

0

High-throughput

0.249

Low

438391

NOT1
General negative regulator of transcription subunit 1

1

0

Small-scale

0.249

Low

438392

CDC48
Cell division control protein 48

1

0

High-throughput

0.249

Low

438406

SMY2
Protein SMY2

1

0

High-throughput

0.249

Low

438416

CENPA
Histone H3-like centromeric protein CSE4

1

0

High-throughput

0.249

Low

438419

ATG8
Autophagy-related protein 8

1

0

High-throughput

0.249

Low

438422

EXO84
Exocyst complex component EXO84

1

0

High-throughput

0.249

Low

438423

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.249

Low

438427

OTU2
OTU domain-containing protein 2

1

0

High-throughput

0.249

Low

438428

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.249

Low

438448

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.249

Low

438460

NSA1
Ribosome biogenesis protein NSA1

1

0

High-throughput

0.249

Low

438464

TR112
Multifunctional methyltransferase subunit TRM112

1

0

Small-scale

0.249

Low

438471

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

438473

CTR9
RNA polymerase-associated protein CTR9

1

0

High-throughput

0.249

Low

438474

2ABA
Protein phosphatase PP2A regulatory subunit B

1

0

High-throughput

0.249

Low

438480

ESP1
Separin

1

0

High-throughput

0.249

Low

438481

SVL3
Styryl dye vacuolar localization protein 3

1

0

High-throughput

0.249

Low

438483

FIN1
Filament protein FIN1

1

0

Small-scale

0.249

Low

438484

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.249

Low

438485

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

438493

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

438494

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

438498

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

438504

SIZ2
E3 SUMO-protein ligase SIZ2

1

0

High-throughput

0.249

Low

438417

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.232

Low

438444

ELO3
Fatty acid elongase 3

1

0

High-throughput

0.232

Low

438470

SFB2
SED5-binding protein 2

1

0

High-throughput

0.232

Low

438509

RUVB2
RuvB-like protein 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025