HitPredict

Interactor 1: IGF1R (P08069)
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Gene: IGF1R

Interactor 2: PFKAP (Q01813)
ATP-dependent 6-phosphofructokinase, platelet type (ATP-PFK) (PFK-P) (EC 2.7.1.11) (6-phosphofructokinase type C) (Phosphofructo-1-kinase isozyme C) (PFK-C) (Phosphohexokinase)
Gene: PFKP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0016020 - membrane GO:0044877 - protein-containing complex binding
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1367 Hs			1 784
+	Hs
		411357 INSR_HUMAN (32-1365): 0: 1219: 56.54		PFKAP_HUMAN (1-784): 0: 1093: 100.00
+	Hs
		411276 INSR_HUMAN (32-1365): 0: 1219: 56.54		PFKAM_HUMAN (13-779): 0: 1030: 71.78
+	Hs
		665468 EPHA8_HUMAN (655-1337): 4.83e-169: 533: 23.87		PFKAP_HUMAN (1-784): 0: 1093: 100.00
+	Hs
		966789 ALK_HUMAN (939-1304): 2.51e-75: 278: 39.12		PFKAP_HUMAN (1-784): 0: 1093: 100.00
+	Hs
		384669 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		PFKAP_HUMAN (1-784): 0: 1093: 100.00
+	Hs
		507955 FGFR1_HUMAN (972-1266): 1.32e-64: 238: 39.54		PFKAP_HUMAN (1-784): 0: 1093: 100.00
+	Hs
		966706 NTRK3_HUMAN (977-1262): 5.74e-64: 236: 39.16		PFKAP_HUMAN (1-784): 0: 1093: 100.00
+	Hs
		384121 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		PFKAM_HUMAN (13-779): 0: 1030: 71.78
+	Hs
		437718 UFO_HUMAN (790-1271): 9.27e-68: 249: 32.10		PFKAM_HUMAN (13-779): 0: 1030: 71.78
+	Hs
		437757 NTRK3_HUMAN (977-1262): 5.74e-64: 236: 39.16		PFKAM_HUMAN (13-779): 0: 1030: 71.78
+	Hs
		571675 EPHA8_HUMAN (655-1337): 4.83e-169: 533: 23.87		PFKAL_HUMAN (396-739): 1.72e-65: 234: 27.03
+	Hs
		384225 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		PFKAL_HUMAN (396-739): 1.72e-65: 234: 27.03
+	Hs
		571677 UFO_HUMAN (790-1271): 9.27e-68: 249: 32.10		PFKAL_HUMAN (396-739): 1.72e-65: 234: 27.03
+	Hs
		571668 FGFR3_HUMAN (972-1266): 2.05e-63: 234: 38.44		PFKAL_HUMAN (396-739): 1.72e-65: 234: 27.03
+	Hs
		445819 ROS1_HUMAN (691-919): 7.36e-11: 69.4: 17.47		PFKAL_HUMAN (396-739): 1.72e-65: 234: 27.03