HitPredict

Interactor 1: CO3A1 (P08121)
Collagen alpha-1(III) chain
Gene: Col3a1

Interactor 2: SMAD2 (Q62432)
Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (Mad-related protein 2) (mMad2) (SMAD family member 2) (SMAD 2) (Smad2)
Gene: SMAD2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	14559231
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001701 - in utero embryonic development GO:0007179 - transforming growth factor beta receptor signaling pathway GO:0007507 - heart development GO:0030324 - lung development GO:0046332 - SMAD binding and 1 others more... GO:0046872 - metal ion binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1464 Mm			1 467
+	Mm
		503177 CO1A1_MOUSE (25-1464): 0: 652: 59.40		SMAD2_MOUSE (1-467): 0: 681: 100.00
+	Hs
		358519 CO1A1_HUMAN (24-1464): 0: 638: 60.47		SMAD2_HUMAN (1-467): 0: 679: 99.57
+	Mm
		503178 CO1A1_MOUSE (25-1464): 0: 652: 59.40		SMAD3_MOUSE (1-467): 0: 621: 83.94
+	Hs
		358494 CO1A1_HUMAN (24-1464): 0: 638: 60.47		SMAD3_HUMAN (1-467): 0: 621: 83.94
+	Mm
		435996 CO3A1_MOUSE (1-1464): 0: 586: 99.59		SMAD3_MOUSE (1-467): 0: 621: 83.94
+	Mm
		435992 CO3A1_MOUSE (1-1464): 0: 586: 99.59		SMAD1_MOUSE (1-467): 0: 575: 55.42
+	Mm
		503173 CO1A1_MOUSE (25-1464): 0: 652: 59.40		SMAD4_MOUSE (11-456): 5.89e-144: 425: 31.63
+	Hs
		358510 CO1A1_HUMAN (24-1464): 0: 638: 60.47		SMAD4_HUMAN (11-456): 4.02e-143: 422: 31.40
+	Mm
		435994 CO3A1_MOUSE (1-1464): 0: 586: 99.59		SMAD4_MOUSE (11-456): 5.89e-144: 425: 31.63
+	Mm
		192481 CO1A1_MOUSE (25-1464): 0: 652: 59.40		SMAD7_MOUSE (13-443): 6.38e-113: 341: 25.06
+	Mm
		192480 CO3A1_MOUSE (1-1464): 0: 586: 99.59		SMAD7_MOUSE (13-443): 6.38e-113: 341: 25.06
+	Mm
		291325 CO5A1_MOUSE (18-486): 1.25e-23: 111: 36.89		SMAD2_MOUSE (1-467): 0: 681: 100.00
+	Mm
		291326 CO5A1_MOUSE (18-486): 1.25e-23: 111: 36.89		SMAD3_MOUSE (1-467): 0: 621: 83.94
+	Mm
		291322 CO5A1_MOUSE (18-486): 1.25e-23: 111: 36.89		SMAD1_MOUSE (1-467): 0: 575: 55.42
+	Mm
		291323 CO5A1_MOUSE (18-486): 1.25e-23: 111: 36.89		SMAD4_MOUSE (11-456): 5.89e-144: 425: 31.63
+	Mm
		192478 CO5A1_MOUSE (18-486): 1.25e-23: 111: 36.89		SMAD7_MOUSE (13-443): 6.38e-113: 341: 25.06