HitPredict

Interactor 1: CO1A2 (P08123)
Collagen alpha-2(I) chain (Alpha-2 type I collagen)
Gene: COL1A2

Interactor 2: MMP14 (P50281)
Matrix metalloproteinase-14 (MMP-14) (EC 3.4.24.80) (MMP-X1) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP)
Gene: MMP14

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	19010413
Identification Methods	protease assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001501 - skeletal system development GO:0005615 - extracellular space GO:0030198 - extracellular matrix organization
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1366 Hs			1 582
+	Hs
		436025 CO1A2_HUMAN (1-1366): 0: 743: 100.00		MMP16_HUMAN (33-582): 0: 759: 55.46
+	Hs
		436024 CO1A2_HUMAN (1-1366): 0: 743: 100.00		MMP15_HUMAN (27-582): 0: 685: 52.48
+	Hs
		436002 CO1A2_HUMAN (1-1366): 0: 743: 100.00		MMP3_HUMAN (11-508): 0: 580: 35.77
+	Hs
		372723 CO1A2_HUMAN (1-1366): 0: 743: 100.00		MMP1_HUMAN (16-508): 0: 567: 35.34
+	Hs
		436012 CO1A2_HUMAN (1-1366): 0: 743: 100.00		MMP8_HUMAN (25-508): 0: 557: 34.02
+	Hs
		436001 CO1A2_HUMAN (1-1366): 0: 743: 100.00		MMP2_HUMAN (4-226): 4.4e-79: 264: 34.78
+	Hs
		436005 CO1A2_HUMAN (1-1366): 0: 743: 100.00		MMP9_HUMAN (4-224): 6.56e-65: 227: 36.20
+	Hs
		358454 CO1A1_HUMAN (20-1019): 8.86e-96: 340: 42.91		MMP2_HUMAN (4-226): 4.4e-79: 264: 34.78
+	Hs
		358587 CO2A1_HUMAN (412-1174): 1.06e-85: 310: 34.44		MMP2_HUMAN (4-226): 4.4e-79: 264: 34.78
+	Hs
		358595 CO2A1_HUMAN (412-1174): 1.06e-85: 310: 34.44		MMP9_HUMAN (4-224): 6.56e-65: 227: 36.20
+	Hs
		439227 CO5A1_HUMAN (1-928): 1.07e-67: 254: 43.30		MMP2_HUMAN (4-226): 4.4e-79: 264: 34.78
+	Hs
		540415 CO5A1_HUMAN (1-928): 1.07e-67: 254: 43.30		MMP9_HUMAN (4-224): 6.56e-65: 227: 36.20
+	Hs
		439220 CO4A2_HUMAN (2-294): 2.25e-27: 123: 29.91		MMP2_HUMAN (4-226): 4.4e-79: 264: 34.78
+	Hs
		439240 CO4A6_HUMAN (2-291): 7.64e-27: 121: 30.62		MMP2_HUMAN (4-226): 4.4e-79: 264: 34.78
+	Hs
		358647 CO4A1_HUMAN (2-287): 9.69e-24: 111: 28.13		MMP2_HUMAN (4-226): 4.4e-79: 264: 34.78
+	Hs
		441053 CO4A2_HUMAN (2-294): 2.25e-27: 123: 29.91		MMP9_HUMAN (4-224): 6.56e-65: 227: 36.20
+	Hs
		358650 CO4A1_HUMAN (2-287): 9.69e-24: 111: 28.13		MMP9_HUMAN (4-224): 6.56e-65: 227: 36.20