HitPredict

Interactor 1: MCR (P08235)
Mineralocorticoid receptor (MR) (Nuclear receptor subfamily 3 group C member 2)
Gene: NR3C2

Interactor 2: NCOA1 (Q15788)
Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1)
Gene: NCOA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	10935545, 15604093
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Hormone_recep~SRC-1
Common GO terms	GO:0000785 - chromatin GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 984 Hs			1 1441
+	Hs
		377354 GCR_HUMAN (490-984): 4.66e-115: 373: 48.35		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		369684 ESR1_HUMAN (512-968): 1.16e-116: 372: 24.49		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		1025256 NR1H3_HUMAN (501-967): 8.86e-114: 359: 21.80		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		414508 PRGR_HUMAN (494-984): 3.65e-106: 354: 46.44		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Mm
		936666 NR1H3_MOUSE (501-967): 4.68e-113: 357: 23.19		NCOA1_MOUSE (1-1441): 3.4e-149: 493: 92.19
+	Hs
		370292 ESR1_HUMAN (512-968): 1.16e-116: 372: 24.49		EPAS1_HUMAN (15-890): 5.41e-104: 354: 13.27
+	Hs
		126095 GCR_HUMAN (490-984): 4.66e-115: 373: 48.35		BMAL1_HUMAN (1-539): 2.88e-105: 350: 16.16
+	Hs
		369703 ESR1_HUMAN (512-968): 1.16e-116: 372: 24.49		HIF1A_HUMAN (8-798): 3.33e-103: 351: 13.33
+	Hs
		369099 ESR1_HUMAN (512-968): 1.16e-116: 372: 24.49		AHR_HUMAN (2-833): 8.86e-80: 284: 13.86
+	Hs
		377843 GCR_HUMAN (490-984): 4.66e-115: 373: 48.35		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Hs
		370839 ESR1_HUMAN (512-968): 1.16e-116: 372: 24.49		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Hs
		1025276 NR1H3_HUMAN (501-967): 8.86e-114: 359: 21.80		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Hs
		414535 PRGR_HUMAN (494-984): 3.65e-106: 354: 46.44		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Hs
		369025 ESR1_HUMAN (512-968): 1.16e-116: 372: 24.49		ARNT_HUMAN (1-642): 5.73e-69: 250: 16.45
+	Hs
		377346 GCR_HUMAN (490-984): 4.66e-115: 373: 48.35		NCOA2_HUMAN (496-1439): 2.6e-11: 70.7: 9.43
+	Hs
		369673 ESR1_HUMAN (512-968): 1.16e-116: 372: 24.49		NCOA2_HUMAN (496-1439): 2.6e-11: 70.7: 9.43
+	Mm
		587102 ESR1_MOUSE (509-968): 6.63e-114: 365: 23.72		NCOA2_MOUSE (496-1439): 7.26e-12: 72.6: 10.82
+	Hs
		69414 ESR1_HUMAN (512-968): 1.16e-116: 372: 24.49		AHRR_HUMAN (29-186): 6.1e-09: 62.8: 31.10
+	Mm
		580480 ANDR_MOUSE (486-984): 3.17e-106: 353: 40.35		NCOA2_MOUSE (496-1439): 7.26e-12: 72.6: 10.82
+	Hs
		414507 PRGR_HUMAN (494-984): 3.65e-106: 354: 46.44		NCOA2_HUMAN (496-1439): 2.6e-11: 70.7: 9.43