HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: SBK2 (P0C263)
Serine/threonine-protein kinase SBK2 (EC 2.7.11.1) (SH3 domain-binding kinase family member 2) (Sugen kinase 69) (SgK069)
Gene: SBK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 348
+	Hs
		431455 HS90A_HUMAN (1-724): 0: 1072: 85.25		SBK2_HUMAN (1-348): 2.39e-156: 443: 100.00
+	Hs
		437928 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT2_HUMAN (17-346): 1.65e-118: 352: 20.46
+	Mm
		513660 HS90B_MOUSE (1-724): 0: 1089: 99.59		AKT1_MOUSE (14-345): 2.89e-116: 346: 19.71
+	Bt
		964601 HS90B_BOVIN (1-724): 0: 1085: 99.59		AKT1_BOVIN (14-345): 5.1e-117: 348: 19.71
+	Hs
		437927 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT1_HUMAN (14-345): 5.67e-116: 345: 19.71
+	Hs
		438633 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT3_HUMAN (4-345): 8.49e-116: 345: 19.22
+	Hs
		437842 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPSH1_HUMAN (7-348): 1.87e-115: 342: 19.31
+	Hs
		438441 HS90B_HUMAN (1-724): 0: 1086: 100.00		KCC1G_HUMAN (49-330): 2.24e-114: 342: 25.35
+	Hs
		431573 HS90A_HUMAN (1-724): 0: 1072: 85.25		AKT2_HUMAN (17-346): 1.65e-118: 352: 20.46
+	Hs
		431572 HS90A_HUMAN (1-724): 0: 1072: 85.25		AKT1_HUMAN (14-345): 5.67e-116: 345: 19.71
+	Hs
		431475 HS90A_HUMAN (1-724): 0: 1072: 85.25		KPSH1_HUMAN (7-348): 1.87e-115: 342: 19.31
+	Hs
		432166 HS90A_HUMAN (1-724): 0: 1072: 85.25		KCC1G_HUMAN (49-330): 2.24e-114: 342: 25.35
+	Hs
		154118 HS90B_HUMAN (1-724): 0: 1086: 100.00		CHK1_HUMAN (60-323): 4.32e-24: 104: 30.26
+	Hs
		437870 HS90B_HUMAN (1-724): 0: 1086: 100.00		KAPCA_HUMAN (13-267): 9.14e-20: 90.9: 30.26
+	Hs
		154117 HS90A_HUMAN (1-724): 0: 1072: 85.25		CHK1_HUMAN (60-323): 4.32e-24: 104: 30.26
+	Hs
		438097 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCZ_HUMAN (62-315): 1.47e-18: 88.6: 30.74
+	Hs
		437898 HS90B_HUMAN (1-724): 0: 1086: 100.00		KAPCG_HUMAN (62-267): 5.14e-18: 85.9: 31.86
+	Hs
		431511 HS90A_HUMAN (1-724): 0: 1072: 85.25		KAPCA_HUMAN (13-267): 9.14e-20: 90.9: 30.26
+	Hs
		431766 HS90A_HUMAN (1-724): 0: 1072: 85.25		KPCZ_HUMAN (62-315): 1.47e-18: 88.6: 30.74
+	Hs
		431537 HS90A_HUMAN (1-724): 0: 1072: 85.25		KAPCG_HUMAN (62-267): 5.14e-18: 85.9: 31.86