HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: ARAF (P10398)
Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks)
Gene: ARAF

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.729

Property	Details
Experiments	29777862, 31980649, 32707033, unassigned2173, 22939624, 25036637
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 606
+	Hs
		431459 HS90A_HUMAN (1-724): 0: 1072: 85.25		ARAF_HUMAN (1-606): 0: 579: 100.00
+	Hs
		432156 HS90A_HUMAN (1-724): 0: 1072: 85.25		Q96II5_HUMAN (1-606): 0: 573: 99.51
+	Hs
		437860 HS90B_HUMAN (1-724): 0: 1086: 100.00		BRAF_HUMAN (3-604): 0: 546: 56.68
+	Hs
		373549 HS90B_HUMAN (1-724): 0: 1086: 100.00		RAF1_HUMAN (13-606): 0: 534: 60.53
+	Hs
		431496 HS90A_HUMAN (1-724): 0: 1072: 85.25		BRAF_HUMAN (3-604): 0: 546: 56.68
+	Mm
		432406 HS90A_MOUSE (1-724): 0: 1068: 84.31		BRAF_MOUSE (3-604): 0: 542: 55.81
+	Hs
		373543 HS90A_HUMAN (1-724): 0: 1072: 85.25		RAF1_HUMAN (13-606): 0: 534: 60.53
+	Rn
		88624 HS90A_RAT (1-724): 0: 1070: 84.45		D3ZHL1_RAT (50-606): 1.21e-128: 401: 25.66
+	Hs
		438332 HS90B_HUMAN (1-724): 0: 1086: 100.00		KSR1_HUMAN (50-606): 7.14e-122: 384: 24.24
+	Hs
		432033 HS90A_HUMAN (1-724): 0: 1072: 85.25		KSR1_HUMAN (50-606): 7.14e-122: 384: 24.24
+	Hs
		433218 HS90B_HUMAN (1-724): 0: 1086: 100.00		YES_HUMAN (289-568): 3.31e-104: 327: 31.34
+	Hs
		437847 HS90B_HUMAN (1-724): 0: 1086: 100.00		SRC_HUMAN (282-568): 1.92e-104: 327: 30.24
+	Hs
		431433 HS90A_HUMAN (1-724): 0: 1072: 85.25		YES_HUMAN (289-568): 3.31e-104: 327: 31.34
+	Hs
		431481 HS90A_HUMAN (1-724): 0: 1072: 85.25		SRC_HUMAN (282-568): 1.92e-104: 327: 30.24
+	Hs
		438285 HS90B_HUMAN (1-724): 0: 1086: 100.00		KSR2_HUMAN (303-584): 2.02e-45: 174: 36.30
+	Hs
		431975 HS90A_HUMAN (1-724): 0: 1072: 85.25		KSR2_HUMAN (303-584): 2.02e-45: 174: 36.30
+	Hs
		411949 HS90B_HUMAN (1-724): 0: 1086: 100.00		FYN_HUMAN (303-568): 1.51e-37: 148: 33.46
+	Hs
		437967 HS90B_HUMAN (1-724): 0: 1086: 100.00		FRK_HUMAN (303-568): 1.34e-36: 145: 33.70
+	Hs
		411945 HS90A_HUMAN (1-724): 0: 1072: 85.25		FYN_HUMAN (303-568): 1.51e-37: 148: 33.46
+	Hs
		431627 HS90A_HUMAN (1-724): 0: 1072: 85.25		FRK_HUMAN (303-568): 1.34e-36: 145: 33.70