HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: FGFR3 (P22607)
Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)
Gene: FGFR3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	35384245, 21487019, 22939624
Identification Methods	affinity chromatography technology, proximity labelling technology, luminescence based mammalian interactome mapping, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005576 - extracellular region GO:0005886 - plasma membrane GO:0009986 - cell surface
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 806
+	Hs
		431536 HS90A_HUMAN (1-724): 0: 1072: 85.25		FGFR3_HUMAN (10-806): 0: 819: 100.00
+	Hs
		438028 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHB1_HUMAN (1-787): 0: 642: 18.08
+	Hs
		431562 HS90A_HUMAN (1-724): 0: 1072: 85.25		EPHA3_HUMAN (1-786): 0: 641: 20.68
+	Hs
		438029 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHA4_HUMAN (1-781): 0: 622: 20.78
+	Hs
		437918 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHA2_HUMAN (1-788): 0: 595: 21.50
+	Hs
		431561 HS90A_HUMAN (1-724): 0: 1072: 85.25		EPHA2_HUMAN (1-788): 0: 595: 21.50
+	Hs
		438205 HS90B_HUMAN (1-724): 0: 1086: 100.00		NTRK3_HUMAN (130-757): 4.66e-167: 506: 24.59
+	Hs
		438213 HS90B_HUMAN (1-724): 0: 1086: 100.00		NTRK2_HUMAN (159-756): 1.53e-161: 491: 25.51
+	Hs
		384122 HS90B_HUMAN (1-724): 0: 1086: 100.00		NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02
+	Hs
		384111 HS90A_HUMAN (1-724): 0: 1072: 85.25		NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02
+	Hs
		431435 HS90A_HUMAN (1-724): 0: 1072: 85.25		RET_HUMAN (453-801): 9.71e-98: 330: 48.63
+	Hs
		437946 HS90B_HUMAN (1-724): 0: 1086: 100.00		TIE1_HUMAN (464-782): 5.85e-69: 249: 44.51
+	Hs
		431591 HS90A_HUMAN (1-724): 0: 1072: 85.25		TIE1_HUMAN (464-782): 5.85e-69: 249: 44.51
+	Hs
		437949 HS90B_HUMAN (1-724): 0: 1086: 100.00		VGFR3_HUMAN (7-245): 8.53e-15: 81: 18.22
+	Hs
		437838 HS90B_HUMAN (1-724): 0: 1086: 100.00		FGFR1_HUMAN (1-114): 1.97e-14: 79.4: 18.32
+	Hs
		437895 HS90B_HUMAN (1-724): 0: 1086: 100.00		FGFR4_HUMAN (1-130): 1.18e-11: 70.5: 19.31
+	Hs
		426977 HS90B_HUMAN (1-724): 0: 1086: 100.00		CSF1R_HUMAN (38-359): 3.54e-11: 69: 18.37
+	Hs
		431472 HS90A_HUMAN (1-724): 0: 1072: 85.25		FGFR1_HUMAN (1-114): 1.97e-14: 79.4: 18.32
+	Hs
		431534 HS90A_HUMAN (1-724): 0: 1072: 85.25		FGFR4_HUMAN (1-130): 1.18e-11: 70.5: 19.31
+	Hs
		426974 HS90A_HUMAN (1-724): 0: 1072: 85.25		CSF1R_HUMAN (38-359): 3.54e-11: 69: 18.37