HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: AKT2 (P31751)
RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-2) (Protein kinase B beta) (PKB beta) (RAC protein kinase beta) (RAC-PK-beta)
Gene: AKT2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	22939624
Identification Methods	luminescence based mammalian interactome mapping, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane and 1 others more... GO:0051726 - regulation of cell cycle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 481
+	Mm
		513660 HS90B_MOUSE (1-724): 0: 1089: 99.59		AKT1_MOUSE (1-478): 0: 566: 81.84
+	Hs
		437927 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT1_HUMAN (1-478): 0: 564: 81.63
+	Hs
		438633 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT3_HUMAN (1-481): 0: 550: 76.61
+	Hs
		437907 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCL_HUMAN (114-478): 7.62e-153: 452: 41.96
+	Hs
		438085 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCE_HUMAN (57-475): 3.59e-147: 439: 39.10
+	Hs
		438094 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCT_HUMAN (85-481): 9.91e-147: 437: 38.19
+	Hs
		408529 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCB_HUMAN (72-478): 5.56e-147: 436: 40.63
+	Hs
		438585 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6B2_HUMAN (115-478): 1.21e-147: 432: 41.58
+	Hs
		437905 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6B1_HUMAN (134-478): 1.35e-146: 431: 44.13
+	Hs
		438422 HS90B_HUMAN (1-724): 0: 1086: 100.00		SGK3_HUMAN (100-476): 1.53e-146: 430: 44.74
+	Hs
		438541 HS90B_HUMAN (1-724): 0: 1086: 100.00		SGK2_HUMAN (124-478): 2.55e-147: 426: 46.94
+	Hs
		116958 HS90B_HUMAN (1-724): 0: 1086: 100.00		SGK1_HUMAN (102-478): 3.87e-145: 423: 43.68
+	Hs
		437870 HS90B_HUMAN (1-724): 0: 1086: 100.00		KAPCA_HUMAN (141-447): 2.12e-144: 419: 41.69
+	Hs
		438193 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6A1_HUMAN (55-456): 2.33e-109: 342: 23.13
+	Hs
		438011 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6A3_HUMAN (55-452): 8.73e-107: 335: 23.36
+	Hs
		438190 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6A2_HUMAN (55-452): 6.02e-107: 335: 23.67
+	Hs
		270364 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6A5_HUMAN (60-406): 1.32e-104: 331: 27.25
+	Hs
		437962 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCI_HUMAN (142-475): 3.18e-106: 330: 46.96
+	Hs
		437869 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCA_HUMAN (146-475): 2.81e-103: 324: 47.43
+	Hs
		438097 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCZ_HUMAN (149-475): 9.44e-101: 315: 46.43