Protein: AKT1
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (AKT1 kinase) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha) (Thymoma viral proto-oncogene)

Gene: AKT1
Organism: Mus musculus
Interactions: 60
UniProt ID: P31750

Gene Ontology (top 5):
GO:0001649 - osteoblast differentiation
GO:0001893 - maternal placenta development
GO:0001938 - positive regulation of endothelial cell proliferation
GO:0002042 - cell migration involved in sprouting angiogenesis
GO:0003376 - sphingosine-1-phosphate receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

728519

GSK3A
Glycogen synthase kinase-3 alpha

3

20

Small-scale

0.845

High

728545

GSK3B
Glycogen synthase kinase-3 beta

3

20

Small-scale

0.845

High

462100

HS90A
Heat shock protein HSP 90-alpha

2

20

Small-scale

0.776

High

312129

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

2

20

Small-scale

0.754

High

728507

AKT1
RAC-alpha serine/threonine-protein kinase

1

17

Small-scale

0.713

High

728532

TRIB3
Tribbles homolog 3

1

17

Small-scale

0.700

High

431326

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.691

High

581952

INSR
Insulin receptor

1

20

Small-scale

0.691

High

86292

CLIP3
CAP-Gly domain-containing linker protein 3

1

8

Small-scale

0.665

High

204222

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

18

Small-scale

0.665

High

266892

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

3

Small-scale

0.647

High

237350

ILK
Scaffold protein ILK

1

11

Small-scale

0.618

High

547236

HS90B
Heat shock protein HSP 90-beta

1

20

Small-scale

0.618

High

728508

CDN1A
Cyclin-dependent kinase inhibitor 1

1

7

Small-scale

0.618

High

728509

VHL
von Hippel-Lindau disease tumor suppressor

1

7

Small-scale

0.618

High

728510

MK14
Mitogen-activated protein kinase 14

1

20

Small-scale

0.618

High

728513

MAPK2
MAP kinase-activated protein kinase 2

1

15

Small-scale

0.618

High

728517

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

18

Small-scale

0.618

High

728518

KPCZ
Protein kinase C zeta type

1

17

Small-scale

0.618

High

728531

DP13A
DCC-interacting protein 13-alpha

1

14

Small-scale

0.618

High

728544

TBK1
Serine/threonine-protein kinase TBK1

1

20

Small-scale

0.618

High

728534

ARRB2
Beta-arrestin-2

2

5

Small-scale

0.611

High

728533

FNDC5
Fibronectin type III domain-containing protein 5

1

0

High-throughput

0.586

High

728520

GRDN
Girdin

1

11

Small-scale

0.586

High

312475

NEMO
NF-kappa-B essential modulator

2

13

Small-scale

0.584

High

728516

TRAF6
TNF receptor-associated factor 6

2

20

Small-scale

0.584

High

728529

ARRB1
Beta-arrestin-1

2

5

Small-scale

0.584

High

591006

KPCE
Protein kinase C epsilon type

1

17

Small-scale

0.575

High

728527

WDFY2
WD repeat and FYVE domain-containing protein 2

1

2

Small-scale

0.575

High

728540

MTOR
Serine/threonine-protein kinase mTOR

2

19

Small-scale

0.571

High

728539

PARVB
Beta-parvin

1

0

Small-scale

0.537

High

98196

UBE4A
Ubiquitin conjugation factor E4 A

1

6

Small-scale

0.536

High

728525

BTBDA
BTB/POZ domain-containing protein 10

1

4

Small-scale

0.515

High

728543

CHIP
E3 ubiquitin-protein ligase CHIP

1

8

Small-scale

0.515

High

728547

HDAC6
Protein deacetylase HDAC6

1

7

Small-scale

0.515

High

723717

CTND1
Catenin delta-1

1

11

Small-scale

0.501

High

728511

SOX2
Transcription factor SOX-2

1

6

Small-scale

0.501

High

728522

H2B2B
Histone H2B type 2-B

1

20

Small-scale

0.501

High

728524

H2B1C
Histone H2B type 1-C/E/G

1

20

Small-scale

0.501

High

728530

KCD20
BTB/POZ domain-containing protein KCTD20

1

4

Small-scale

0.501

High

109319

G5E8T2
E3 ubiquitin-protein ligase TTC3

1

9

Small-scale

0.479

High

572873

HSPB1
Heat shock protein beta-1

1

14

Small-scale

0.479

High

662948

MDM2
E3 ubiquitin-protein ligase Mdm2

1

6

Small-scale

0.479

High

686931

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

20

Small-scale

0.479

High

728512

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C]

1

14

Small-scale

0.479

High

728514

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

5

Small-scale

0.479

High

728515

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

15

Small-scale

0.479

High

728521

BAD
Bcl2-associated agonist of cell death

1

6

Small-scale

0.479

High

728523

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

5

Small-scale

0.479

High

728526

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

5

Small-scale

0.479

High

728528

SMAD3
Mothers against decapentaplegic homolog 3

1

9

Small-scale

0.479

High

728535

PAWR
PRKC apoptosis WT1 regulator protein

1

2

Small-scale

0.479

High

728536

HSPB2
Heat shock protein beta-2

1

14

Small-scale

0.479

High

728537

AKTS1
Proline-rich AKT1 substrate 1

1

5

Small-scale

0.479

High

728538

TSC1
Hamartin

1

14

High-throughput

0.479

High

728542

PEPL
Periplakin

1

12

High-throughput

0.457

High

728541

FOXO1
Forkhead box protein O1

1

11

Small-scale

0.445

High

728546

PDE3A
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

1

5

Small-scale

0.445

High

398120

CFAD
Complement factor D

1

3

High-throughput

0.437

High


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Last updated: 11Aug2025