HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: KC1A (P48729)
Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1)
Gene: CSNK1A1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	32707033, 22939624
Identification Methods	affinity chromatography technology, pull down, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 337
+	Hs
		438069 HS90B_HUMAN (1-724): 0: 1086: 100.00		KC1G2_HUMAN (1-336): 5.29e-122: 358: 48.82
+	Hs
		431731 HS90A_HUMAN (1-724): 0: 1072: 85.25		KC1G2_HUMAN (1-336): 5.29e-122: 358: 48.82
+	Hs
		437991 HS90B_HUMAN (1-724): 0: 1086: 100.00		KC1E_HUMAN (9-311): 8.5e-115: 340: 74.26
+	Hs
		437928 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT2_HUMAN (1-335): 1.7e-112: 336: 16.67
+	Bt
		964601 HS90B_BOVIN (1-724): 0: 1085: 99.59		AKT1_BOVIN (1-335): 3.02e-111: 333: 16.04
+	Hs
		437870 HS90B_HUMAN (1-724): 0: 1086: 100.00		KAPCA_HUMAN (5-335): 5.11e-112: 330: 17.46
+	Hs
		431646 HS90A_HUMAN (1-724): 0: 1072: 85.25		KC1A_HUMAN (1-337): 1.03e-115: 340: 100.00
+	Hs
		431573 HS90A_HUMAN (1-724): 0: 1072: 85.25		AKT2_HUMAN (1-335): 1.7e-112: 336: 16.67
+	Hs
		431511 HS90A_HUMAN (1-724): 0: 1072: 85.25		KAPCA_HUMAN (5-335): 5.11e-112: 330: 17.46
+	Sc
		365925 HSP82_YEAST (12-724): 0: 927: 61.26		HRR25_YEAST (9-306): 4.96e-120: 356: 63.76
+	Zm
		35496 A0A1D6LMW9_MAIZE (5-693): 0: 852: 46.66		A0A1D6QH07_MAIZE (6-337): 5.96e-111: 331: 17.28