HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: KC1G2 (P78368)
Casein kinase I isoform gamma-2 (CKI-gamma 2) (EC 2.7.11.1)
Gene: CSNK1G2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 415
+	Hs
		437984 HS90B_HUMAN (1-724): 0: 1086: 100.00		KC1A_HUMAN (30-363): 1.01e-131: 383: 49.10
+	Hs
		437928 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT2_HUMAN (5-399): 1.01e-121: 363: 16.46
+	Hs
		437905 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6B1_HUMAN (1-415): 9.69e-119: 357: 17.01
+	Mm
		513660 HS90B_MOUSE (1-724): 0: 1089: 99.59		AKT1_MOUSE (3-388): 3.48e-118: 354: 17.56
+	Hs
		437907 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCL_HUMAN (8-392): 1.27e-116: 356: 17.60
+	Bt
		964601 HS90B_BOVIN (1-724): 0: 1085: 99.59		AKT1_BOVIN (3-388): 7.55e-119: 356: 17.81
+	Hs
		437927 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT1_HUMAN (3-388): 2.63e-118: 354: 17.81
+	Hs
		438633 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT3_HUMAN (9-374): 7.45e-118: 353: 16.94
+	Hs
		437870 HS90B_HUMAN (1-724): 0: 1086: 100.00		KAPCA_HUMAN (3-368): 9.97e-119: 351: 18.82
+	Hs
		437900 HS90B_HUMAN (1-724): 0: 1086: 100.00		KAPCB_HUMAN (3-368): 2.18e-118: 350: 19.62
+	Hs
		438585 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6B2_HUMAN (18-415): 1.11e-115: 347: 16.67
+	Hs
		437898 HS90B_HUMAN (1-724): 0: 1086: 100.00		KAPCG_HUMAN (3-368): 5.24e-116: 344: 17.47
+	Hs
		431542 HS90A_HUMAN (1-724): 0: 1072: 85.25		KS6B1_HUMAN (1-415): 9.69e-119: 357: 17.01
+	Hs
		431548 HS90A_HUMAN (1-724): 0: 1072: 85.25		KPCL_HUMAN (8-392): 1.27e-116: 356: 17.60
+	Hs
		431572 HS90A_HUMAN (1-724): 0: 1072: 85.25		AKT1_HUMAN (3-388): 2.63e-118: 354: 17.81
+	Hs
		431511 HS90A_HUMAN (1-724): 0: 1072: 85.25		KAPCA_HUMAN (3-368): 9.97e-119: 351: 18.82
+	Hs
		437991 HS90B_HUMAN (1-724): 0: 1086: 100.00		KC1E_HUMAN (39-415): 1.17e-112: 337: 47.29
+	Hs
		431538 HS90A_HUMAN (1-724): 0: 1072: 85.25		KAPCB_HUMAN (3-368): 2.18e-118: 350: 19.62
+	Hs
		70435 HS90A_HUMAN (1-724): 0: 1072: 85.25		B2RB89_HUMAN (3-368): 2.18e-118: 350: 19.62
+	Hs
		431537 HS90A_HUMAN (1-724): 0: 1072: 85.25		KAPCG_HUMAN (3-368): 5.24e-116: 344: 17.47